Salmon sperm DNA prevents acute liver injury by regulating alcohol‐induced steatosis and restores chronic hepatosis via alleviating inflammation and apoptosis

Abstract

Current medications used to treat alcoholic liver injury (ALD) can cause secondary damage to the liver. Therefore, it is important to improve alcoholic liver injury from the perspective of dietary and nutritional supplementation. Nucleic acids, as functional biomolecules, are present in almost all foods, especially in aquatic products, but their edible research has been neglected for a long time. Hence, the effects of a typical aquatic nucleic acid, namely, salmon sperm DNA, in acute, and chronic alcoholic liver injury model of male ICR mice were studied. The results showed that salmon sperm DNA significantly attenuated the accumulation of cholesterol (TC) and triglycerides (TG) in acute alcoholic liver injury, and it was further demonstrated to mainly regulate lipid metabolism by fluorescent quantitative PCR and immunoblotting experiments. In addition, nucleic acid intervention alleviated inflammation and apoptosis in mice with chronic alcoholic liver injury. Practical applications These results suggest that salmon sperm DNA can prevent and ameliorate alcoholic liver injury and can be used as an effective dietary and nutritional supplement for the prevention and treatment of ALD. Moreover, this study provided some new ideas for the development and utilization of large aquatic nucleic acid resources, promoted the comprehensive use of fish processing waste, such as fish sperm, and provided new directions for reducing emissions.

Efficacy of Rhamnus utilis Decne. Aqueous extract in mice with acute alcoholic liver injury and metabolomic study

“…During acute alcoholic liver injury, alcohol induces excessive production of reactive oxygen species (ROS), leading to elevated levels of liver lipids [ 22 , 23 ], oxidative stress [ 24 ], and release of inflammatory cytokines including TNF-α, IL-6, and IL-1β [ 25 ], thereby exacerbating inflammation [ 26 ]. In this study, we observed that RDAE mitigated alcohol-induced weight loss and attenuated the increase in liver index.…”

Suppression of Ehrlich ascites tumor cell proliferation via G1 arrest induced by dietary nucleic acid-derived nucleosides

“…Dietary nucleic acids have been found to have various physiological effects in vivo , other than being recycled through the salvage pathway. Their effects have attracted attention, and the physiological effects of dietary nucleic acids reported so far include the maintenance of immune responses [ 1 – 3 ], suppression of inflammation in adipose tissue [ 4 ], improvement of glucose tolerance [ 4 ], and protection of liver function [ 5 , 26 ]. In this study, we discovered that dietary nucleic acids and guanosine have an inhibitory effect on cancer cell proliferation.…”

Stress Reduction Potential in Mice Ingesting DNA from Salmon Milt

“…As a mechanism of action, experiments using hepatocytes have shown that deoxyadenosine in salmon milt extract may suppress liver inflammation [49]. On the other hand, salmon sperm DNA has also been reported to prevent liver inflammation [50,51]. DNA-Na supplementation significantly suppressed increases in CtsB and IL-1β mRNA associated with stress-induced hippocampal inflammatory responses.…”