Salmonella enterica Serotype Gambia with CTX-M-3 and armA Resistance Markers: Nosocomial Infections with a Fatal Outcome

Abstract

International audienceWe report two cases of bacteremia caused by the Salmonella enterica serotype Gambia in our children's hospital, with one fatal outcome. The isolates showed indistinguishable genotypes and infrequent resistance markers: CTX-M-3 extended-spectrum β-lactamase and armA methyltransferase. This is the first report of S. Gambia exhibiting CTX-M-3 and armA markers involved in serious infections

Prevalence of Salmonella Bloodstream Infection and Antimicrobial Resistance in Lagos, Nigeria.

“…Real-time PCR rotor-gene Q 2plex (Qiagen, Germany) was used to amplify and detect Salmonella virulence gene invA [39][40][41] . The used oligonucleotide sequences specific for the detection of invA in Salmonella and Citrobacter freundii as previously used by Choudhury et al (2016) [39] , Moissenet et al (2011) [40] , and Tennant and Levine (2015) [41] are shown in Table 1.…”

16S rRNA Methyltransferases: An Emerging Resistance Mechanism Against Aminoglycosides in Salmonella

“…80-kb IncL/M plasmid bearing armA and CTX-M-3 together with sulphonamide and trimethoprim resistance determinants in France (Moissenet et al, 2011). The strains isolated from two babies in the intensive care unit of a Paris hospital in 2005 shared identical resistance profiles (resistance to cefotaxime, ceftazidime, gentamicin, tobramycin, amikacin and cotrimoxazole) and indistinguishable PFGE patterns.…”