Salmonella enterica serovar Typhi osteomyelitis in a young adult with sickle cell and thalassemia traits: A possible association

Stephanie, Stephanie; Schmalzle, Sarah

doi:10.1016/j.idcr.2018.e00478

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…Arizonae and Salmonella Typhi [ 4 , 5 , 6 ]. Analysis of Salmonella Osteomyelitis by Stephanie and Schmalzle revealed that most of the osteomyelitis patients have an underlying predisposing condition such as sickle cell trait, thalassemia trait, and other hemoglobinopathes [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Case Report of Pediatric Osteomyelitis: A Double Whammy of Unusual Etiology and Antibiotic Susceptibility

Bhavana¹,

Inna²,

Mahalingam³

et al. 2023

JOCR

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Introduction: Osteomyelitis is one of the infrequent presentations of Salmonella infection. Most of the case reports are among adult patients. It is very rare in children, and is most often associated with hemoglobinopathies or other predisposing clinical conditions. Case Report: In this article, we present a case of osteomyelitis caused by Salmonella enterica serovar Kentucky, in a previously healthy 8-year-old child. Further, this isolate had an unusual susceptibility pattern; it showed resistance to the third-generation cephalosporins, akin to ESBL production among Enterobacterales. Conclusion: Osteomyelitis caused by Salmonella does not have any specific clinical or radiological features, both in adult and pediatric age groups. A high index of suspicion, using appropriate testing methodologies and awareness about emerging drug resistance helps in accurate clinical management. Keywords: Salmonella, pediatric, immunocompetant, osteomyelitis.

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Section: Discussionmentioning

confidence: 99%

Case Report of Pediatric Osteomyelitis: A Double Whammy of Unusual Etiology and Antibiotic Susceptibility

Bhavana¹,

Inna²,

Mahalingam³

et al. 2023

JOCR

View full text Add to dashboard Cite

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“…[20][21][22] Although she was incidentally diagnosed to have alpha 2-thalassemia minor, minor forms of the thalassemia trait as a predisposing factor for Salmonella infections are not as well described as underlying established hemoglobinopathies, such as sickle cell anemia, thalassemia with high iron load, or previous splenectomy. [23][24][25][26][27][28] Generally, NTS as a renal pathogen is unusual, and an occult urologic problem or an immunodeficiency should be considered. 16 Most reported pediatric renal abscess cases were managed with antibiotic therapy as a mainstay, and in some cases, with concomitant abscess drainage (Table 3).…”

Section: Discussionmentioning

confidence: 99%

Salmonella Renal Abscess in an Immunocompetent Child: Case Report and Literature Review

Poh

Seah

Chong

et al. 2021

Global Pediatric Health

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“…Other microorganisms include Escherichia coli, Streptococcus, Klebsiella and Proteus (Zhan et al 2018). Osteomyelitis caused by Salmonella has been reported sporadically (Hashimoto et al 2018;Stephanie and Schmalzle 2019;Zhan et al 2018), but little is known about its pathogenesis. Salmonella can cause a variety of clinical forms, including sepsis, typhoid fever, gastroenteritis, localized organ disease, and asymptomatic chronic carrier state (Zhan et al 2018).…”

Section: Introductionmentioning

confidence: 99%

“…However, salmonella osteomyelitis is rare, accounting for only 0.8% of all cases of salmonella infection, and is the causal microorganism in 0.45% of all cases of osteomyelitis (Sanchez et al 1996). Salmonella osteomyelitis is predominantly common in patients with sickle cell disease or thalassemia and immunocompetent (Tóth et al 2002;Stephanie and Schmalzle 2019). Salmonella osteomyelitis is an infection of the long bones, primarily the diaphysis of the femur and humerus; other bones that are involved include the lumbar spine, tibia, radius, and ulna (McAnearney and McCall 2015).…”

Section: Introductionmentioning

confidence: 99%

Salmonella Osteomyelitis of the Rib Mimicking a Mammary Tumor: A Case Report

Hashimoto

Nishimura

Matsumura

et al. 2020

Tohoku J. Exp. Med.

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Salmonella infection predominantly causes four clinical syndromes: enteric fever, gastroenteritis, bacteremia, and asymptomatic carrier state. Salmonella osteomyelitis is an extremely rare manifestation of salmonella infection except in children with hemoglobinopathies. Salmonella osteomyelitis has been reported to mostly affect the diaphysis of long bones and lumbar spine. Here, we describe a case of salmonella osteomyelitis of the right 6th rib in a 74-year-old woman who presented with breast pain, swelling, high fever and local heat. Her medical history showed myocardial infarction; namely, at the age of 71, the patient had undergone the drug-eluting stent placement in the left anterior descending artery. A computed tomography (CT) scan at the first visit to another hospital showed a mass in the chest that invaded the ribs. 18 F-fluorodeoxyglucose-positron emission tomography-computed tomography imaging showed a lesion suspected to be a mammary malignant tumor. A needle biopsy revealed mesenchymal cells and suspected mammary sarcoma. However, the osteomyelitis of the rib was diagnosed when pyogenic tissue was observed during an open biopsy. The bacterial culture examination identified Salmonella enterica. Surgical drainage and antibiotic treatment were performed. Importantly, there was no evidence for any underlying disease that could lead to an immunocompromised status of the patient. To our knowledge, this is the first report of salmonella osteomyelitis of the rib presenting in an older female that required differentiation from a mammary tumor. Clinicians should consider rib osteomyelitis when they find swelling and local heat in the female's breast tissue and detect no cancerous tissue.

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Salmonella enterica serovar Typhi osteomyelitis in a young adult with sickle cell and thalassemia traits: A possible association

Cited by 5 publications

References 17 publications

Case Report of Pediatric Osteomyelitis: A Double Whammy of Unusual Etiology and Antibiotic Susceptibility

Case Report of Pediatric Osteomyelitis: A Double Whammy of Unusual Etiology and Antibiotic Susceptibility

Salmonella Renal Abscess in an Immunocompetent Child: Case Report and Literature Review

Salmonella Osteomyelitis of the Rib Mimicking a Mammary Tumor: A Case Report

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