Salmonella infection in an anterior mediastinal mass

Carter, Yvonne M.; Shagrun, Lamia; Klein, Harold P.; Katz, Jeffrey A.; Jablons, David M.

doi:10.1016/j.jtcvs.2004.04.042

Cited by 5 publications

(9 citation statements)

References 5 publications

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“…Extrapolating from the literature, an isolated T cell immunodeficiency appears to be even more common in thymoma patients (6-8) than classical Good's syndrome (46). Our findings extend the observation that patients with thymoma have increased percentages of naive T cells (4,47), and they also suggest that the diminished presence of CD247 in the TCR complex in thymoma patients may lead to T cell immunodeficiency and opportunistic infections with intracellular pathogens, such as Cryptococcus (8), tuberculosis (48), and salmonellosis (49). Similar to our patient B, the clinical presentation in each of these case reports was dominated by a single infection.…”

Section: Discussionsupporting

confidence: 78%

A Novel Thymoma-Associated Immunodeficiency with Increased Naive T Cells and Reduced CD247 Expression

Christopoulos

Dopfer

Malkovsky

et al. 2015

The Journal of Immunology

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The mechanisms underlying thymoma-associated immunodeficiency are largely unknown, and the significance of increased blood γδ Τ cells often remains elusive. In this study we address these questions based on an index patient with thymoma, chronic visceral leishmaniasis, myasthenia gravis, and a marked increase of rare γδ T cell subsets in the peripheral blood. This patient showed cutaneous anergy, even though he had normal numbers of peripheral blood total lymphocytes as well as CD4+ and CD8+ T cells. Despite his chronic infection, analyses of immunophenotypes and spectratyping of his lymphocytes revealed an unusual accumulation of naive γδ and αβ T cells, suggesting a generalized T cell activation defect. Functional studies in vitro demonstrated substantially diminished IL-2 and IFN-γ production following TCR stimulation of his “untouched” naive CD4+ T cells. Biochemical analysis revealed that his γδ and αβ T cells carried an altered TCR complex with reduced amounts of the ζ-chain (CD247). No mutations were found in the CD247 gene that encodes the homodimeric ζ protein. The diminished presence of CD247 and increased numbers of γδ T cells were also observed in thymocyte populations obtained from three other thymoma patients. Thus, our findings describe a novel type of a clinically relevant acquired T cell immunodeficiency in thymoma patients that is distinct from Good’s syndrome. Its characteristics are an accumulation of CD247-deficient, hyporresponsive naive γδ and αβ T cells and an increased susceptibility to infections.

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Section: Discussionsupporting

confidence: 78%

A Novel Thymoma-Associated Immunodeficiency with Increased Naive T Cells and Reduced CD247 Expression

Christopoulos

Dopfer

Malkovsky

et al. 2015

The Journal of Immunology

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“…There has only been one previous case report describing Salmonella bacteremia associated with a thymic abscess within a thymoma [ 1 ]. In this report, Carter et al .…”

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confidence: 99%

“…In this report, Carter et al . [ 1 ] suggested a multimodal approach. Using CT of the chest, they were able to obtain an accurate definition of the mass, with respect to malignant potential, and also develop a surgical plan, using the delineated anatomy.…”

mentioning

confidence: 99%

“…Carter et al . [ 1 ] pursued surgical resection of their patient's mass once her sepsis resolved. Specifically, they performed an en bloc resection of the thymus, decortication, and copious irrigation through a median sternotomy, which they felt would adequately treat the infection process as well as any potential neoplasms.…”

mentioning

confidence: 99%

“…The patient described by Carter et al . [ 1 ] underwent a wedge resection of the medial aspect of the lower lobe. In our patient, however, in order to obtain en bloc resection of the mass, a right pneumonectomy was possible.…”

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confidence: 99%

See 2 more Smart Citations

Letter to the Editor Non-typhoidal Salmonella abscess in a patient with a large thymoma: a rare presentation and review of the literature

Lo¹,

Aronow²,

Tantchou³

et al. 2015

aoms

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Nontyphoidal Salmonella as a Cause of Mediastinal Abscess after Aortic Valve Replacement: A Case Report and Review of Postoperative Salmonella Infections

Spottiswoode

Peluso

Deuse

et al. 2018

Case Reports in Infectious Diseases

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Background Nontyphoidal Salmonella (NTS) is a pathogen that causes several human clinical illnesses, most commonly gastroenteritis. Focal infections are rare and are generally reported in the gastrointestinal and genitourinary systems. Very few studies have reported NTS abscess as a postoperative complication. Case report We describe an elderly patient who developed NTS bacteremia and mediastinal abscess after aortic valve replacement. Conclusions This report describes an extremely rare occurrence of an NTS mediastinal abscess complicating a surgical procedure. The patient may have acquired the pathogen from a snake kept as a family pet and likely developed bacteremia followed by seeding of the surgically damaged tissues.

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Salmonella infection in an anterior mediastinal mass

Cited by 5 publications

References 5 publications

A Novel Thymoma-Associated Immunodeficiency with Increased Naive T Cells and Reduced CD247 Expression

A Novel Thymoma-Associated Immunodeficiency with Increased Naive T Cells and Reduced CD247 Expression

Letter to the Editor Non-typhoidal Salmonella abscess in a patient with a large thymoma: a rare presentation and review of the literature

Nontyphoidal Salmonella as a Cause of Mediastinal Abscess after Aortic Valve Replacement: A Case Report and Review of Postoperative Salmonella Infections

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