Salmonella infections: immune and non-immune protection with vaccines

Effect of genetic resistance of the hen toSalmonellacarrier-state on incidence of bacterial contamination: synergy with vaccination

“…Protais et al [10] investigated the effect of vaccination on two poultry lines (which differed in susceptibility of Salmonella) and found that the vaccine efficiency was related to the susceptibility. These authors and general literature on vaccination (see for example the review by Barrow [1]) showed that the vaccination, as other factors is linked to the characteristic of the immune protection. To have a first estimation of the effect that could be expected from vaccination, we used what Barrow [1] calls a gold standard, which is infection with a wild-type strain.…”

“…These authors and general literature on vaccination (see for example the review by Barrow [1]) showed that the vaccination, as other factors is linked to the characteristic of the immune protection. To have a first estimation of the effect that could be expected from vaccination, we used what Barrow [1] calls a gold standard, which is infection with a wild-type strain. We thus assumed that vaccination would result in the same immunity as the one observed in formerly contaminated hens that are in the recovered state.…”

Characterization of aSalmonellaTyphimurium ghost carrying an adjuvant protein as a vaccine candidate for the protection of chickens against virulent challenge

“…enterica serovar Typhimurium (Salmonella Typhimurium), a non-host-adapted Gram-negative intracellular pathogen, is capable of infecting a variety of animal hosts and humans (Barrow, 2007). In South Korea, the prevalence of Salmonella Typhimurium is widely reported in the broiler and layer chicken farms or poultry products (Rayamajhi et al, 2010;Kim et al, 2012;Choi et al, 2014).…”

“…However, the persistence of live attenuated strains in vaccinated birds and their surrounding premises is a major disadvantage that may be a potential threat to human health (Tan et al, 1997). In addition, there is the possibility of reversion to virulence in live vaccine strains developed by mutagenesis, which is also a disadvantage (Barrow, 2007;Gast, 2007). Traditionally produced killed vaccines and subunit-based vaccines are safe and generate a good humoral immune response, but lack the ability to induce a strong cell-mediated immune response (Barrow, 2007;Desin et al, 2013).…”

“…In addition, there is the possibility of reversion to virulence in live vaccine strains developed by mutagenesis, which is also a disadvantage (Barrow, 2007;Gast, 2007). Traditionally produced killed vaccines and subunit-based vaccines are safe and generate a good humoral immune response, but lack the ability to induce a strong cell-mediated immune response (Barrow, 2007;Desin et al, 2013). In addition, killed and subunit vaccine formulations also require the use of additional adjuvants for optimal benefit.…”