Salmonella Meningitis

Rabinowitz, Stanley G.

doi:10.1001/archpedi.1972.02110090129023

Cited by 38 publications

(1 citation statement)

References 23 publications

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“…Meningitis due to Gramnegative enteric organisms in 12 of the 120 patients (10%) in the present series is one of the highest reported in recent years. Salmonella meningitis in infancy and childhood has been noted in epidemics (25) while Entrrohcictrr c l o r i c c i c~, Klebsiella and Acinetobacter species have been implicated in nosocomial infections (15). Although infection with unusual organisms in malnourished children have been documented (22).…”

Section: Discussionmentioning

confidence: 99%

Bacterial Meningitis in Childhood in an African City

Hailemeskel

Tafari

1978

Acta Paediatrica

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In a retrospective study of 120 children aged 1 month and above with bacterial meningitis confirmed by positive CSF culture, 88.4% were found to be due to three common organisms: H. influenzae, Str. pneumoniae and N. meinigitidis. Gram-negative enteric organisms accounted for 10% of the infections. Despite intensive antibiotic and ancillary therapy, there has been no significant change in case fatality and sequelae over the past decade in this institution. The present study confirms that factors related to the organism and the host are important in determining the outcome of therapy. H. influenzae and Str. pneumoniae infections are associated with statistically significant rise in case fatality rate and neurologic sequelae at the end of therapy. The presence of neurological abnormality at the time of diagnosis significantly increases case fatality rate while delay in diagnosis appears to primarily influence the frequency of neurological sequelae. Protein-energy malnutrition increases the frequency of neurological sequelae and death from bacterial meningitis without significantly influencing the pattern of bacterial aetiology. The finding of enteric Gram-negative meningitis in association with diarrhoeal disease in the present study adds a new dimension to one of the most prevalent health problems in developing countries and needs to be confirmed.

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Section: Discussionmentioning

confidence: 99%