Salmonella necrotizing infection on the background of diabetes mellitus (clinical, pathological and anatomical case)

Павлов, К. О.; Федосеев, В. Ф.; Тюлюбаев, В. С.; Игумнова, Т. В.; Малявский, И. Ю.

doi:10.25199/2408-9613-2018-6-1-44-47

Cited by 1 publication

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“…Therefore, in a context of an infected diabetic foot ulcer, the exosomes could be employed as a treatment, supported in biological processes by Panther ontology, especially biological adhesion. Predictions in the METASCAPE online server remarked on possible pathways that match with previous software mentioned, and a new method of regulation for Salmonella infection that we hope can be used against infection, given that case reports have been published in human diabetic ulcers [28,29]. In addition, the heatmap from METASCAPE matched with the predictions from the last software, focusing on infection control, the formation of blood vessels, and the induction of proliferation in cells present in the dermis.…”

Section: Discussionmentioning

confidence: 78%

Putative Wound Healing Induction Functions of Exosomes Isolated from IMMUNEPOTENT CRP

Coronado

Franco‐Molina

Zárate-Triviño

et al. 2023

IJMS

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Chronic wounds in diabetic patients can take months or years to heal, representing a great cost for the healthcare sector and impacts on patients’ lifestyles. Therefore, new effective treatment alternatives are needed to accelerate the healing process. Exosomes are nanovesicles involved in the modulation of signaling pathways that can be produced by any cell and can exert functions similar to the cell of origin. For this reason, IMMUNEPOTENT CRP, which is a bovine spleen leukocyte extract, was analyzed to identify the proteins present and is proposed as a source of exosomes. The exosomes were isolated through ultracentrifugation and shape-size, characterized by atomic force microscopy. The protein content in IMMUNEPOTENT CRP was characterized by EV-trap coupled to liquid chromatography. The in silico analyses for biological pathways, tissue specificity, and transcription factor inducement were performed in GOrilla ontology, Panther ontology, Metascape, and Reactome. It was observed that IMMUNEPOTENT CRP contains diverse peptides. The peptide-containing exosomes had an average size of 60 nm, and exomeres of 30 nm. They had biological activity capable of modulating the wound healing process, through inflammation modulation and the activation of signaling pathways such as PIP3-AKT, as well as other pathways activated by FOXE genes related to specificity in the skin tissue.

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Section: Discussionmentioning

confidence: 78%

Putative Wound Healing Induction Functions of Exosomes Isolated from IMMUNEPOTENT CRP

Coronado

Franco‐Molina

Zárate-Triviño

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

Salmonella necrotizing infection on the background of diabetes mellitus (clinical, pathological and anatomical case)

Abstract: The article presents a clinical, pathological and anatomical case of an extremely rare form of necrotizing infection as a metastatic suppurative lesion in salmonellosis in a patient with diabetes mellitus. The complexities of the differential diagnosis and diagnosis is discussed.

Cited by 1 publication

References 1 publication

Putative Wound Healing Induction Functions of Exosomes Isolated from IMMUNEPOTENT CRP

Putative Wound Healing Induction Functions of Exosomes Isolated from IMMUNEPOTENT CRP

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