Salmonella Pullorum effector SteE regulates Th1/Th2 cytokine expression by triggering the STAT3/SOCS3 pathway that suppresses NF-κB activation

Liu, Zhike; Wang, Li; Gao, Pei; Yu, Yan; Zhang, Yanhong; Фотин, А. И.; Wang, Qiuxia; Zhang, Xu; Wei, Xiaobing; Фотіна, Т. І.; Ma, Junfeng

doi:10.1016/j.vetmic.2023.109817

Cited by 2 publications

(1 citation statement)

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“…TA supplementation improved the goblet cell count and increased the expression of tight junction proteins and MUC2, with the most significant effect observed in the TAM group. S. pullorum is a facultative intracellular parasitic bacterium that primarily induces Th2-type immune responses, which may contribute to its persistence and infection ( 40 – 42 ). Secretory immunoglobulin A (sIgA) is a crucial marker of intestinal immunity ( 43 , 44 ).…”

Section: Discussionmentioning

confidence: 99%

Gallnut tannic acid alleviates gut damage induced by Salmonella pullorum in broilers by enhancing barrier function and modulating microbiota

Zou,

Luan,

et al. 2024

Front. Vet. Sci.

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Pullorum disease (PD) is a bacterial infection caused by Salmonella pullorum (S. pullorum) that affects poultry. It is highly infectious and often fatal. Antibiotics are currently the mainstay of prophylactic and therapeutic treatments for PD, but their use can lead to the development of resistance in pathogenic bacteria and disruption of the host's intestinal flora. We added neomycin sulfate and different doses of tannic acid (TA) to the drinking water of chicks at 3 days of age and infected them with PD by intraperitoneal injection of S. pullorum at 9 days of age. We analyzed intestinal histopathological changes and the expression of immune-related genes and proteins by using the plate smear method, histological staining, real-time fluorescence quantitative PCR, ELISA kits, and 16S rRNA Analysis of intestinal flora. The results demonstrate that S. pullorum induces alterations in the immune status and impairs the functionality of the liver and intestinal barrier. We found that tannic acid significantly ameliorated S. pullorum-induced liver and intestinal damage, protected the intestinal physical and chemical barriers, restored the intestinal immune barrier function, and regulated the intestinal flora. Our results showed that TA has good anti-diarrhoeal, growth-promoting, immune-regulating, intestinal barrier-protecting and intestinal flora-balancing effects, and the best effect was achieved at an additive dose of 0.2%.

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