Salt and Aldosterone – Reciprocal and Combined Effects in Preclinical Models and Humans

Abstract

Primary aldosteronism is an endocrine disorder caused by excessive production of aldosterone by the adrenal glands, which is recognized as the most important cause of endocrine hypertension. In addition, is represents a potentially curable form of hypertension. The independent role of high salt intake as a mediator of cardiovascular disease has been confirmed. Observational and experimental data suggest that aldosterone-induced organ damage requires plasma aldosterone levels to be inappropriate for salt status. Therefore, understanding the relationship between plasma aldosterone levels and dietary salt intake and the interaction between the two is crucial for developing effective prevention and treatment strategies. In this review, we present an update on findings about primary aldosteronism and salt intake and the underlying mechanisms governing their interaction.

The Adrenal Gland: A Fascinating Object of Research and Clinical Care Showcased at the 15th German Adrenal Conference in Dresden

“…Finally, the work by Chen et al 11 disentangles the adverse outcome of mineralocorticoid excess and salt overload. The authors provide a comprehensive overview from experimental models and to research in humans that will certainly inform clinical decision making and counseling.…”