Salt and water transport across the alveolar epithelium in the developing lung: correlations between function and recent molecular biology advances (Review).

Folkesson, H. G.; Norlin, Andreas; Baines, Deborah L.

doi:10.3892/ijmm.2.5.515

Cited by 16 publications

(24 citation statements)

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“…Consequently, more ␤-adrenoceptors and higher ␤-adrenoceptor stimulation may lead to increased Na ϩ and fluid transport. The molecular mechanisms for this has been suggested to be stimulation of the apically located amiloride-sensitive ENaC (10,18,19,21,31,37,48) and increased expression and activity of basolateral Na-KATPases (6,23,48). Previously, we found significant increases in ENaC and Na-K-ATPase expression after IL-1␤ administration at both 61 and 68 days gestation (48).…”

Section: Discussionmentioning

confidence: 64%

“…All of this prepared the lungs for labor induction, having an additive stimulatory effect on lung fluid absorption after IL-1␤ stimulation and preterm delivery. It has also been demonstrated (3,5,6,19,31) that lung fluid is reabsorbed secondary to Na ϩ absorption and that this Na ϩ transport can be stimulated by agonist binding to ␤-adrenoceptors. Consequently, more ␤-adrenoceptors and higher ␤-adrenoceptor stimulation may lead to increased Na ϩ and fluid transport.…”

Section: Discussionmentioning

confidence: 98%

“…Therefore, water movement (absorption or secretion) will result in a change in air space protein concentration. Because fetal lungs are fluid-filled in utero (6,19), we expected that a certain fraction of fluid would still be present in the lungs at the time of experiment. This fluid is virtually protein-free and will not add protein to the instilled albumin concentration.…”

Section: Lung Fluid Absorption Measurementsmentioning

confidence: 99%

“…Lung fluid absorption depends on water absorption secondary to Na ϩ transport via amiloride-sensitive and -insensitive pathways (19,36). We therefore used amiloride to investigate whether IL-1␤-stimulated lung fluid absorption was associated with amiloride-sensitive Na ϩ transport.…”

Section: Effect Of Amiloride On Lung Fluid Absorptionmentioning

confidence: 99%

“…IL-1␣ also improved postnatal lung function with increased surfactant pool size without eliciting systemic inflammatory responses in lambs (14, 47). We recently reported that IL-1␤ pretreatment of timed-pregnant guinea pigs induced fluid absorption in fetal lungs, sodium transporter protein, and ␤-adrenoceptor expression via hypothalamus-pituitary-adrenal gland axis stimulation (48).Lung fluid absorption occurs secondarily to transepithelial Na ϩ absorption (3,5,8,17,22,31,35,37,45,48,49) and is driven by basolateral Na-K-ATPases (16, 23) and apical epithelial sodium channels (19,22,30,31). Fluid absorption occurs in near-term lungs (6,17,35,37,45) and is induced/ stimulated by cortisol and triiodothyronine (2, 20, 48) and labor-released epinephrine (17,35,45).…”

mentioning

confidence: 99%

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Oxytocin-induced labor augments IL-1β-stimulated lung fluid absorption in fetal guinea pig lungs

Nair¹,

Li²,

Bhattacharjee³

et al. 2005

American Journal of Physiology-Lung Cellular and Molecular Phys

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-We tested the hypothesis that oxytocin-induced labor augmented IL-1␤-induced/ -stimulated lung fluid absorption in preterm guinea pig fetuses. IL-1␤ was administered subcutaneously daily to timed-pregnant guinea pigs for 3 days with and without simultaneous cortisol synthesis inhibition by metyrapone. At day 3, oxytocin was administered, and fetuses were delivered by abdominal hysterotomy at 61 and by oxytocin-induced birth at 68 days gestation. Delivered fetuses were instilled with isosmolar 5% albumin into the lungs, and lung fluid movement was measured over 1 h by mass balance. Lung fluid absorption was induced in 61-day and stimulated in 68-day gestation lungs by IL-1␤. Labor induction by oxytocin augmented IL-1␤-induced/-stimulated lung fluid absorption. Metyrapone pretreatment did not affect oxytocin-induced/-stimulated lung fluid absorption, while completely blocking IL-1␤-induced/-stimulated fluid absorption. Fetal lung fluid absorption, when present, was always propranolol and amiloride sensitive, suggesting that ␤-adrenoceptor stimulation and amiloridesensitive sodium channels were critical for fluid absorption. Epithelial sodium channel and Na-K-ATPase subunit expressions were both increased by IL-1␤, but not further by oxytocin. Our results indicate that IL-1␤ release into the maternal blood circulation positively affects lung maturation due to the IL-1␤-induced release of cortisol and thus prepares the lungs for the epinephrine surge associated with labor.␤-adrenoceptors; cortisol; epinephrine; prenatal lung development; sodium transport CYTOKINES, SUCH AS INTERLEUKIN-1 (IL-1), can be important during pregnancy, because IL-1 has been detected in the placenta and amniotic fluid (12,44). In this regard, interleukins have been proposed as a signal for parturition onset, as cytokines can stimulate prostaglandin biosynthesis (41). During normal pregnancies, IL-1 is present in the amniotic fluid in low concentrations, but during preterm labor much higher amniotic fluid IL-1 concentrations are present (44). Intrauterine infection/inflammation may further elevate cytokine levels, the highest activity being attributable to IL-1␤ (44). Many prematurely born infants suffer from fetal infection and/or respiratory distress syndrome (RDS), both of which are important reasons for mortality of premature babies. Recent human data suggest that ion transport abnormalities across lung epithelial cells, i.e., an incomplete transition of lung fluid secretion to lung fluid absorption, can contribute to RDS development (1). Factors accelerating ion transport across alveolar cells may thus have benefits for the resolution of RDS. Recent experimental data have suggested that proinflammatory cytokines could also promote lung maturation (9,14,26,47). IL-1␣ increased mRNA surfactant protein expression and improved lung compliance in fetal rabbits (9). IL-1␣ also improved postnatal lung function with increased surfactant pool size without eliciting systemic inflammatory responses in lambs (14, 47). We recently reported that IL-...

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 98%

Section: Lung Fluid Absorption Measurementsmentioning

confidence: 99%

Section: Effect Of Amiloride On Lung Fluid Absorptionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Oxytocin-induced labor augments IL-1β-stimulated lung fluid absorption in fetal guinea pig lungs

Nair¹,

Li²,

Bhattacharjee³

et al. 2005

American Journal of Physiology-Lung Cellular and Molecular Phys

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Fatty Acid Modulation and Sequence Identity of Fetal Guinea Pig Alveolar Type II Cell Amiloride-Sensitive Na+ Channel

Baines

MacGregor

Kemp

2001

Biochemical and Biophysical Research Communications

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The Hormonal Control of Uterine Luminal Fluid Secretion and Absorption

et al. 2005

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The secretion of uterine luminal fluid initially provides a transport and support medium for spermatozoa and unimplanted embryos, while the absorption of uterine luminal fluid in early pregnancy results in the closure of the lumen and allows blastocysts to establish intimate contact with the uterine epithelium. We have established an in vivo perfusion technique of the lumen to study the hormonal control of the events in the peri-implantation period. Fluorescein-labelled dextran was included in the perfusion medium to monitor fluid movements and the concentrations of Na(+) and CI(-) ions in the effluent were monitored. Using an established regimen of steroid treatment of ovariectomized rats mimicking early pregnancy, oestradiol caused fluid secretion, while progesterone resulted in an amiloride-sensitive fluid absorption. Fluid absorption peaked at about the expected time of implantation. The effect of progesterone could be inhibited by treatment with a high dose of oestradiol, by the anti-progestin RU486, and by the presence of an intra-uterine contraceptive device. Studies of expression of Na(+) and CI(-) channels (ENaC, CFTR) indicated that these channels were subject to tissue-specific regulation within the uterus, but more work is required to determine their role and the factors controlling their abundance and localization in early pregnancy.

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Salt and water transport across the alveolar epithelium in the developing lung: correlations between function and recent molecular biology advances (Review).

Cited by 16 publications

References 0 publications

Oxytocin-induced labor augments IL-1β-stimulated lung fluid absorption in fetal guinea pig lungs

Oxytocin-induced labor augments IL-1β-stimulated lung fluid absorption in fetal guinea pig lungs

Fatty Acid Modulation and Sequence Identity of Fetal Guinea Pig Alveolar Type II Cell Amiloride-Sensitive Na+ Channel

The Hormonal Control of Uterine Luminal Fluid Secretion and Absorption

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