Salt-dependent hypertension and inflammation: targeting the gut–brain axis and the immune system with Brazilian green propolis

Batista, Marcos Adriano Carlos; Braga, Daiane Cristina de Assis; Moura, Sandra Aparecida Lima de; Souza, Gustavo Henrique Bianco de; Santos, Orlando David Henrique dos; Cardoso, Leonardo Máximo

doi:10.1007/s10787-020-00742-2

Cited by 14 publications

(12 citation statements)

References 156 publications

(221 reference statements)

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“…Contrary to our findings, experimental studies have shown the antihypertensive effects of propolis. Angiotensin-converting enzyme inhibitor-like effect, diuretic effects, activation of nitric oxide pathway, acetylcholine-induced vasodilation, and the antioxidant and anti-inflammatory properties of propolis are among the suggested mechanisms 12 , 26 , 34 – 40 . The vasorelaxant effects of propolis also occur as a result of inhibitory action on calcium movements through smooth muscle cells membrane 40 .…”

Section: Discussionmentioning

confidence: 99%

The effects of propolis on pro-oxidant–antioxidant balance, glycemic control, and quality of life in chronic kidney disease: a randomized, double-blind, placebo-controlled trial

Anvarifard

Ostadrahimi

Ardalan

et al. 2023

Sci Rep

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Chronic kidney disease (CKD) is a progressive kidney damage with an increasing prevalence. Some evidence suggests that propolis as a novel antioxidant, anti-inflammatory, and immunomodulatory agent may have beneficial effects in CKD. The aim of this study was to evaluate the efficacy of propolis on some kidney function parameters, pro-oxidant–antioxidant balance (PAB), glycemic status, quality of life, and blood pressure (BP) in patients with CKD. In this study, 44 patients with CKD were randomly assigned to receive propolis capsules at a dose of 250 mg daily or placebo for three months. Of 44 randomized individuals, 35 completed the trial. At the end of the intervention (end of month three), improvement in some dimensions of health-related quality of life (HRQoL) (derived from Kidney Disease and Quality of Life Short-Form (KDQOL-$${\mathrm{SF}}^{\mathrm{TM}}$$ SF TM , v. 1.3) questionnaire) were significantly higher in the propolis group than the placebo group, even after adjustment for baseline values, present of diabetes, and age (P < 0.05). Like systolic and diastolic BP, changes in serum creatinine, 24-h urine volume and protein, fasting blood sugar (FBS), hemoglobin A1C (HbA1C), insulin, homeostasis model of assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), and PAB did not differ significantly between the two groups (P > 0.05). No serious adverse events were reported throughout the study. Propolis supplementation may improve the HRQoL of CKD patients. More studies are needed to validate the adjunct use of propolis for metabolic control of CKD patients.

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Section: Discussionmentioning

confidence: 99%

The effects of propolis on pro-oxidant–antioxidant balance, glycemic control, and quality of life in chronic kidney disease: a randomized, double-blind, placebo-controlled trial

Anvarifard

Ostadrahimi

Ardalan

et al. 2023

Sci Rep

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“…Propolis, also known as bee glue, has previously been reported to exhibit pharmacological actions, including cardioprotective effects [ 15 ]. Propolis contains a variety of active ingredients, among which flavonoids are the most biologically active components [ 14 ]. Prior work has shown that FP can attenuate pathological cardiac hypertrophy and collagen deposition in isoproterenol-treated mice through inhibition of the PI3K/AKT signaling pathway [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Propolis is a dietary supplement derived from a resinous hive product collected by honeybees from various exudates of trees and plants [ 13 ]. Propolis has been shown to possess protective effects against hypertension [ 14 ] and atherosclerosis [ 15 ]. Flavonoids are major functional components of propolis, which have a long history of therapeutic use.…”

Section: Introductionmentioning

confidence: 99%

Flavonoid Extract from Propolis Provides Cardioprotection following Myocardial Infarction by Activating PPAR-γ

Wang

Chen

Tang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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We have previously reported that flavonoid extract from propolis (FP) can improve cardiac function in rats following myocardial infarction (MI). However, the mechanisms responsible for the cardioprotective effects of FP have not been fully elucidated. In the current study, we explored whether FP can reduce inflammatory cytokines and attenuate sympathetic nerve system activity and antiendoplasmic reticulum (ER) stress and whether the cardioprotective effects are related to peroxisome proliferator-activated receptor gamma (PPAR-γ) activation. Sprague Dawley rats were randomly divided into six groups: Sham group received the surgical procedure but no artery was ligated; MI group received ligation of the left anterior descending (LAD) branch of the coronary artery; MI + FP group received FP (12.5 mg/kg/d, intragastrically) seven days prior to LAD ligation; FP group (Sham group + 12.5 mg/kg/d, intragastrically); MI + FP + GW9662 group received FP prior to LAD ligation with the addition of a specific PPAR-γ inhibitor (GW9662), 1 mg/kg/d, orally); and MI + GW9662 group received the PPAR-γ inhibitor and LAD ligation. The results demonstrated that the following inflammatory markers were significantly elevated following MI as compared with expression in sham animals: IL-1β, TNF-α, CRP; markers of sympathetic activation: plasma norepinephrine, epinephrine and GAP43, nerve growth factor, thyroid hormone; and ER stress response markers GRP78 and CHOP. Notably, the above changes were attenuated by FP, and GW9662 was able to alleviate the effect of FP. In conclusion, FP induces a cardioprotective effect following myocardial infarction by activating PPAR-γ, leading to less inflammation, cardiac sympathetic activity, and ER stress.

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“…5 In addition to its effect on BP, gut microbiota is associated with hypertensive target organ damage, for example, kidney and brain damage. 6,7 One study found that the changes in the intestinal microflora induced intestinal immunological gene expression and gut permeability and gut bacteria translocation into the kidney. 8 The gut and kidneys play an important role in regulating BP.…”

Section: Impact Statementmentioning

confidence: 99%

Calcitriol ameliorates damage in high-salt diet-induced hypertension: Evidence of communication with the gut–kidney axis

Ding

Xiao

Jiang

et al. 2021

Exp Biol Med (Maywood)

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Several studies have established a link between high-salt diet, inflammation, and hypertension. Vitamin D supplementation has shown anti-inflammatory effects in many diseases; gut microbiota is also associated with a wide variety of cardiovascular diseases, but potential role of vitamin D and gut microbiota in high-salt diet-induced hypertension remains unclear. Therefore, we used rats with hypertension induced by a high-salt diet as the research object and analyzed the transcriptome of their tissues (kidney and colon) and gut microbiome to conduct an overall analysis of the gut–kidney axis. We aimed to confirm the effects of high salt and calcitriol on the gut–kidney immune system and the composition of the intestinal flora. We demonstrate that consumption of a high-salt diet results in hypertension and inflammation in the colon and kidney and alteration of gut microbiota composition and function. High-salt diet-induced hypertension was found to be associated with seven microbial taxa and mainly associated with reduced production of the protective short-chain fatty acid butyrate. Calcitriol can reduce colon and kidney inflammation, and there are gene expression changes consistent with restored intestinal barrier function. The protective effect of calcitriol may be mediated indirectly by immunological properties. Additionally, the molecular pathways of the gut microbiota-mediated blood pressure regulation may be related to circadian rhythm signals, which needs to be further investigated. An innovative association analysis of the microbiota may be a key strategy to understanding the association between gene patterns and host.

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Salt-dependent hypertension and inflammation: targeting the gut–brain axis and the immune system with Brazilian green propolis

Cited by 14 publications

References 156 publications

The effects of propolis on pro-oxidant–antioxidant balance, glycemic control, and quality of life in chronic kidney disease: a randomized, double-blind, placebo-controlled trial

The effects of propolis on pro-oxidant–antioxidant balance, glycemic control, and quality of life in chronic kidney disease: a randomized, double-blind, placebo-controlled trial

Flavonoid Extract from Propolis Provides Cardioprotection following Myocardial Infarction by Activating PPAR-γ

Calcitriol ameliorates damage in high-salt diet-induced hypertension: Evidence of communication with the gut–kidney axis

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