Salt influence in the polymer-surfactant interaction in solution. A fluorescence probe investigation of the EHEC/SDS/ water system

Holmberg, Christina; Evertsson, Hans

doi:10.1007/s003960050155

Cited by 17 publications

(2 citation statements)

References 51 publications

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“…Although the ion type had minimal effect on the aggregation behavior, the polymer-bile salt interactions were highly influenced by the ionic strength of the media. [58] The results demonstrated the complexity of interactions between the polymer and bile salts in biorelevant conditions. In particular, obtained data highlighted the formation of either NaTC aggregates or individual micelles growing in size, which are expected to play a role in drug solubilisation in the gut, when the drug is delivered by hydrophilic polymer based dispersions.…”

Section: Discussionmentioning

confidence: 87%

Probing the molecular interactions between pharmaceutical polymeric carriers and bile salts in simulated gastrointestinal fluids using NMR spectroscopy

Pigliacelli

Belton

Wilde

et al. 2019

Journal of Colloid and Interface Science

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The number of poorly soluble new drugs is increasing and one of the effective ways to deliver such pharmaceutically active molecules is using hydrophilic polymers to form a solid dispersion. Bile salts play an important role in the solubilisation of poorly soluble compounds in the gut prior to absorption. When a poorly water-soluble drug is delivered using a hydrophilic polymer based solid dispersion oral formulation, it is still unclear whether there are any polymer-bile salt interactions, which may influence the drug dissolution and solubilisation. This study, using two widely used hydrophilic model polymers, Hydroxypropyl methylcellulose (HPMC) and polyvynilpirrolidone (PVP), and sodium taurocholate (NaTC) as the model bile salt, aims to investigate the interactions between the polymers and bile salts in simulated fed state (FeSSIF) and fasted state (FaSSIF) gut fluids. The nature of the interactions was characterised using a range of NMR techniques. The results revealed that the aggregation behaviour of NaTC in FaSSIF and FeSSIF is much more complex than in water. The addition of hydrophilic polymers led to the occurrences of NaTC-HPMC and NaTC-PVP aggregation. For both systems, pH and ionic strength strongly influenced the aggregation behavior, while the ion type played a less significant role. The outcome of this study enriched the understanding of the aggregation behaviour of bile salts and typical hydrophilic pharmaceutical polymers in bio-relevant media. Due to the highly surfaceactive behaviour of the bile salts, such aggregation behaviour is expected to play a role in drug solubilisation in the gut when the drug is delivered by hydrophilic polymer based dispersions.

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Section: Discussionmentioning

confidence: 87%

Probing the molecular interactions between pharmaceutical polymeric carriers and bile salts in simulated gastrointestinal fluids using NMR spectroscopy

Pigliacelli

Belton

Wilde

et al. 2019

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

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“…It is expected that, also in the dilute concentration regime, the dynamics of the molecules should be affected by factors such as temperature, surfactant concentration, and salinity. Recently, various aspects of the dilute solution behavior of EHEC have been studied with the aid of equilibrium dialysis, [16][17][18][19][20][21] conductivity, 17,20,22,23 fluorescence quenching, 16,18,[21][22][23] titration calorimetry, [24][25][26] surface tension, 27 viscosity, 17,19,21,24,25,28 and dynamic light scattering. [28][29][30] However, a systematic investigation of how temperature, surfactant concentration, and salinity affect the dynamics of dilute EHEC solutions is still lacking.…”

Section: Introductionmentioning

confidence: 99%

Effects of Temperature, Surfactant Concentration, and Salinity on the Dynamics of Dilute Solutions of a Nonionic Cellulose Derivative

1998

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The interaction between sodium dodecyl sulfate (SDS) and ethyl(hydroxyethyl)cellulose (EHEC) has been studied as a function of temperature in dilute aqueous solutions in the presence of various amounts of SDS and at some different levels of NaCl addition with the aid of dynamic light scattering (DLS). The DLS results suggest initially an exponential decay followed by a stretched exponential at longer times. The fast mode is always diffusive, and the results are presented in terms of the hydrodynamic radius. The slow mode exhibits a stronger and more complex wave vector dependence than the fast mode. The interaction between the polymer and surfactant gives rise to the formation of polymer−surfactant clusters at low levels of surfactant addition. The cluster size increases at low surfactant concentrations and passes through a maximum slightly above the critical aggregation concentration. In this process, the interplay between swelling and deaggregation of the clusters plays an important role. The position of the maximum is shifted toward lower SDS concentrations with increasing temperature. At low levels of surfactant addition, the growth of the aggregates is promoted by increasing temperature and salinity. As the surfactant concentration increases, the aggregates gradually become disrupted and the impact of temperature and salinity on the size of the polymer aggregates becomes small.

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Influence of Counterion on the Interaction of Dodecyl Sulfates and Cellulose Ethers

Ridell

Evertsson

Nilsson

2002

Journal of Colloid and Interface Science

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Salt influence in the polymer-surfactant interaction in solution. A fluorescence probe investigation of the EHEC/SDS/ water system

Cited by 17 publications

References 51 publications

Probing the molecular interactions between pharmaceutical polymeric carriers and bile salts in simulated gastrointestinal fluids using NMR spectroscopy

Probing the molecular interactions between pharmaceutical polymeric carriers and bile salts in simulated gastrointestinal fluids using NMR spectroscopy

Effects of Temperature, Surfactant Concentration, and Salinity on the Dynamics of Dilute Solutions of a Nonionic Cellulose Derivative

Influence of Counterion on the Interaction of Dodecyl Sulfates and Cellulose Ethers

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