Salts and Water

Edmonds, C. J.

doi:10.1007/978-1-4684-3336-4_4

Cited by 5 publications

(2 citation statements)

References 167 publications

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“…is identical with that found by Edmonds (1967) in rats perfused with potassiumfree solutions. This rather large flux is unexpected from comparative passive permeabilities of the small and large intestine, and can probably be explained by active potassium secretion in the colon, while potassium transport in the small intestine is purely passive (Edmonds 1974). The increased rate of secretion in the presence of surfactants is again consistent with increased passive permeability.…”

Section: Glucose Control Experimentsmentioning

confidence: 65%

Glucose and Cation Transport in Rat Jejunum, Ileum and Colonin Vivo: Control Experiments, and Effect of Cationic Surfactant

Sund

1978

Acta Pharmacologica et Toxicologica

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Osmotically balanced solutions of glucose (0.5-300 mM) and sodium chloride, containing cetrimonium bromide (cetrimide, 0.84.1 mM), were instilled into the jejunum, ileum and colon of anaesthetized rats. Net transport of glucose, sodium and potassium was studied by their disappearance from, or accumulation into the intestinal lumen during 15 min incubation. Cetrimide caused the following shifts in normal jejunal and ileal glucose absorption: At low luminal glucose levels, absorption was strongly depressed and may be converted to net secretion. At intermediate levels, inhibition was less pronounced, and at high luminal glucose levels absorption was enhanced. Similar changes were seen in the colon. Furthermore, cetrimide caused a threefold change in the regression lines relating net sodium fluxes to the initial sodium concentration: The lines became steeper, the correlation was improved and the sodium concentration value corresponding to zero net transport was elevated. Net potassium secretion was increased. -These changes are all consistent with the view that surfactants cause an increase in passive epithelial permeability. Quantitatively, the effect of cetrimide increased with localization in the order colon > ileum >jejunum. Benzalkonium chloride (0.5-1.7 mM) was tested in the ileum only, and caused quite similar effects.

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Section: Glucose Control Experimentsmentioning

confidence: 65%

Glucose and Cation Transport in Rat Jejunum, Ileum and Colonin Vivo: Control Experiments, and Effect of Cationic Surfactant

Sund

1978

Acta Pharmacologica et Toxicologica

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“…The digestive system is responsible for absorption of potassium ions [11][12][13][14][15][16][17][18][19][20][21][22][23]. Unlike other herbivores, such as cattle and sheep, human beings only carry out simple digestion of food in the stomach.…”

Section: Characteristics In the Absorption Storage And Use Of Potassi...mentioning

confidence: 99%

Relative Deficiency of Intracellular Potassium in Relation to the Functional Changes and Diseases in Non-Nervous System

Dai¹

2022

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Because of the huge differences in cellular structures and functions in non-nervous system and interaction between the nervous and non-nervous systems in potassium ion absorption, storage and effective utilization, the organs, tissues and tissue cells in non-nervous system have different functional dependence on potassium ion and its characteristics in competitive distribution differences. Therefore, I propose that the relative deficiency of potassium in cells in non-nervous organs and tissues may show very different functional changes and disease characteristics. Some are susceptible to pathogenic microorganisms, some may result in decrease of cell functions, and other may have comprehensive changes such as chronic inflammation. Therefore, the core causes for the functional changes and lesions of these nonnervous organs and tissues are closely related to the relative deficiency of potassium ions in their cells, which provides important ideas for the prevention and treatment of these functional changes and diseases.

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Segmental heterogeneity of epithelial transport in rat large intestine

1978

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Functionally isolated segments of rat colon and rectum were perfused in situ in a closed loop system. Rectum was defined as the lower 25--35% of the length of large intestine (cecum excluded). Perfusion conditions were optimized at 0.5 ml.min-1 and 3 cm H2O luminal pressure. Variation of perfusion rate between 0.2 and 2 ml.min-1 did not influence net volume transport (JNV). Luminal distension following elevation of hydrostatic pressure to 18 cm H2O reversibly increased Jnv. Under control conditions Jnv and Na+-transport rates (JnNa) of colon were 2--3 times higher than those of rectum. In colon transepithelial electrical potential difference (psims) was time independent --12 mV (lumen negative) whereas rectal psims increased with time from --6 mV, reaching a plateau of --67 mV within 6 h. Amiloride 10(-4) mol.l-1 had no effect on psims, Jnv, and JnNa in colon but did slightly depress K+-secretion in colon descendens. In contrast, psims in rectum was dose-dependently depressed, being reversed to +7 mV at 10(-4) mol.l-1. Jnv and JnNa were decreased by half. Acetazolamide in addition to amiloride lowered the positive post-amiloride rectal psims by half. Adrenalectomy had no effect on colonic psims, but abolished psims of the rectum. A single dose of 40 microgram.kg-1 b.w. aldosterone during the experiment restored the typical time course of rectal psims, but did not affect psims in colon. It is concluded that aldosterone induces an amiloride-sensitive Na+-pathway only in rectum, but not in colon, and that colon and rectum differ basically in their transport properties, quantitatively as well as qualitatively, as do the kidney distal convoluted tubule and the cortical collecting duct.

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Salts and Water

Cited by 5 publications

References 167 publications

Glucose and Cation Transport in Rat Jejunum, Ileum and Colonin Vivo: Control Experiments, and Effect of Cationic Surfactant

Glucose and Cation Transport in Rat Jejunum, Ileum and Colonin Vivo: Control Experiments, and Effect of Cationic Surfactant

Relative Deficiency of Intracellular Potassium in Relation to the Functional Changes and Diseases in Non-Nervous System

Segmental heterogeneity of epithelial transport in rat large intestine

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