Salusins and adropin: New peptides potentially involved in lipid metabolism and atherosclerosis

Niepolski, Leszek; Grzegorzewska, Alicja E.

doi:10.1016/j.advms.2016.03.007

Cited by 32 publications

(29 citation statements)

References 50 publications

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“…These results suggested that salusin-α might improve atherosclerosis by inhibiting VSMC migration and proliferation via regulation of the mTOR pathway. Although the salusin-α receptor has not yet been identified, we speculate that salusin-α may exert its physiological functions by binding to cell surface receptors [17,31,32]. Also unclear is whether salusin-α inhibits the migration and proliferation of SMCs via attenuation of the effects of salusin-β.…”

Section: Discussionmentioning

confidence: 91%

“…Atherosclerosis development is accelerated by salusin-β via increased acyl-coenzyme A:cholesterol acyltransferase-1 expression in human monocyte-derived macrophages, whereas salusin-α may have the opposite effect: serum salusin-α levels are inversely correlated with the maximum intima-media thickness in patients with coronary artery disease [15,16]. Although there is a link between salusin-α and atherosclerosis [11,16,17], it is unclear whether salusin-α plays a role in the proliferation and migration of SMCs, another important cellular event in atherosclerotic lesion formation, even though some reports have shown that salusin-β promotes SMC migration and proliferation and vascular inflammation and fibrosis [18][19][20]. In this study, we attempted to examine the effects of salusin-α on rabbit atherosclerosis, with emphasis on the role of the peptide in SMCs and the underlying mechanisms.…”

Section: Introductionmentioning

confidence: 99%

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Salusin-α Inhibits Proliferation and Migration of Vascular Smooth Muscle Cell via Akt/mTOR Signaling

Gao

Zhang

et al. 2018

Cell Physiol Biochem

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Background/Aims: The proliferation and migration of vascular smooth muscle cells (VSMCs) are key steps in the progression of atherosclerosis. The aim of the present study was to investigate the potential roles of salusin-α in the functions of VSMCs during the development of atherosclerosis. Methods: In vivo, the effects of salusin-α on atherogenesis were examined in rabbits fed a cholesterol diet. The aortas were en face stained with Sudan IV to evaluate the gross atherosclerotic lesion size. The cellular components of atherosclerotic plaques were analyzed by immunohistochemical methods. In vitro, Cell Counting Kit-8 and wound-healing assays were used to assess the effects of salusin-α on VSMC proliferation and migration. In addition, western blotting was used to evaluate the total and phosphorylated levels of Akt (also known as protein kinase B) and mammalian target of rapamycin (mTOR) in VSMCs. Results: Salusin-α infusion significantly reduced the aortic lesion areas of atherosclerosis, with a 39% reduction in the aortic arch, a 71% reduction in the thoracic aorta, and a 71% reduction in the abdominal aorta; plasma lipid levels were unaffected. Immunohistochemical staining showed that salusin-α decreased both macrophage- and VSMC-positively stained areas in atherosclerotic lesions by 54% and 69%, cell proliferative activity in the intima and media of arteriosclerotic lesions, and matrix metalloproteinase 2 (MMP-2) and MMP-9 expression in plaques. Studies using cultured VSMCs showed that salusin-α decreased VSMC migration and proliferation via reduced phosphorylation of Akt and mTOR. Conclusion: Our data indicate that salusin-α suppresses the development of atherosclerosis by inhibiting VSMC proliferation and migration through the Akt/mTOR pathway.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Salusin-α Inhibits Proliferation and Migration of Vascular Smooth Muscle Cell via Akt/mTOR Signaling

Gao

Zhang

et al. 2018

Cell Physiol Biochem

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“…Our results are in agreement with previously published studies. Kumar et al confirmed that AdrKO mice rapidly exhibited dyslipidemia [23], therapy with synthetic adropin improves fatty liver and dyslipidemia in mouse models of obesity [24]. There is very limited research on the relationship between apelin − 12 and lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Adropin and Apelin -12, two better predictors of metabolic syndrome in obese children

Xiao

zhang²,

zhang

et al. 2020

Preprint

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Background: Metabolic syndrome (MetS) is the most extensively described condition associated with childhood and adolescent obesity and is a challenging public health issue. Studies regarding the specificity and sensitivity of serum levels of adropin and apelin -12 as predictors of MetS are limited. The aim was to evaluate the prospective association between adropin and apelin -12 concentrations and MetS and sensitivity as predictors of MetS in the obese children.Methods:: This study involved 138 children. The study group included obese subjects with MetS and the two control groups included obese without MetS and normal weight subjects. Anthropometric parameters and clinical data were collected. Plasma levels of apelin -12, adropin, leptin, adiponectin and TNF-α were measured. Results: Obese children with MetS had significantly higher levels of apelin -12 and significantly lower levels of adropin compared to those without MetS. In logistic regressions, we identified that apelin -12 was risk factor for metabolic syndrome and adropin was the protecting factors of having MetS after adjustment for age, sex and puberty. Furthermore, adropin and apelin -12 are two more sensitive predictors of metabolic syndrome than leptin and adiponect using ROC method. Conclusion: Serum adropin and apelin -12 levels can be useful biomarkers for evaluation of the risk of MetS in obese children. This may provide a novel approach for treatment or prevention of MetS development.

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“…The peripheral effect is potentially atherosclerotic. Serum level increases of salusin β have been observed in patients with coronary artery disease and diseases that lead to cardiovascular disorders (8) (19). Elevated serum salusin β was observed in children with primary hypertension and was positively correlated with the serum triglyceride level and triglyceride/HDL-cholesterol ratio (20).…”

Section: The Research By Ociepa Et Al Reported a Prevalence Of Hypermentioning

confidence: 99%

Serum level of salusin β as an indicator of metabolic disorders in Acute Lymphoblastic Leucaemia and Wilms Tumour survivors

Janecka

Stefanowicz

Owczarzak

et al. 2020

Preprint

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Background Cardiovascular diseases (CVD) are one of long-term side effects of the childhood cancers treatment. Salusin β is an indicator of developing atherosclerosis. Aim To assess the prevalence of established risk factors for CVD and the assessment of new indicator for CVD risk - salusin β in long-term acute lymphoblastic leukemia (ALLs) and Wilms tumour (WTs) survivors. Methods 37 ALLs and 11 WTs at least 5 years after the end of oncological treatment undergone physical examination and laboratory tests after an overnight fast. Laboratory tests included lipid profile, serum level of glucose, renal parameters and salusin β. Results The both groups didn’t vary in age, time from the end of the treatment, number of obese persons, BP, lipid profile, serum creatinine and glucose level. ALLs had higher weight and greater waist circumference. Serum cystatin was higher and cystatin-based eGFR lower among WTs. Salusin β was higher in group WTs, but the result was not statistically significant. Conclusions ALLs and WTs differ in types of long-term side effects. ALLs present rather metabolic problems, WTs - lower eGFR. Salusin β seems to implicate development of hypertension rather than metabolic disorders like obesity. Further investigations are necessary to confirm this statement.

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Salusins and adropin: New peptides potentially involved in lipid metabolism and atherosclerosis

Cited by 32 publications

References 50 publications

Salusin-α Inhibits Proliferation and Migration of Vascular Smooth Muscle Cell via Akt/mTOR Signaling

Salusin-α Inhibits Proliferation and Migration of Vascular Smooth Muscle Cell via Akt/mTOR Signaling

Adropin and Apelin -12, two better predictors of metabolic syndrome in obese children

Serum level of salusin β as an indicator of metabolic disorders in Acute Lymphoblastic Leucaemia and Wilms Tumour survivors

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