Salutary actions of nimodipine in traumatic shock

Lefer, Allan M.; Carrow, Breck A.

doi:10.1016/0024-3205(81)90678-0

Cited by 14 publications

(3 citation statements)

References 12 publications

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“…In rats subjected to traumatic shock, nimodipine by infusion at 50 p,g/kg/hr for the duration of the experiment (up to 4 hr) prolonged the survival of animals (44).…”

Section: Other Pharmacological Effectsmentioning

confidence: 95%

Nimodipine

Scriabine

Battye

Hoffmeister³

et al. 1985

Cardiovascular Drug Reviews

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“…In rats subjected to traumatic shock, nimodipine by infusion at 50 p,g/kg/hr for the duration of the experiment (up to 4 hr) prolonged the survival of animals (44).…”

Section: Other Pharmacological Effectsmentioning

confidence: 95%

Nimodipine

Scriabine

Battye

Hoffmeister³

et al. 1985

Cardiovascular Drug Reviews

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“…DHPs were also shown to have some protective effects in several shock models. It has been reported that nimodipine has beneficial effects on traumatic shock in rats 10 and nitrendipine in hemorrhagic shocked cats!". Moreover, nisoldipine has been shown to prevent the sudden death of rabbits after arachidonate administration-".…”

mentioning

confidence: 99%

Inhibition of lipid peroxidation by some dihydropyridine derivatives

1993

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The efficacy of dihydropyridine derivatives in inhibiting lipid peroxidation was studied using modified Buege and Aust's method. The method first involves keeping a decapitated rat head at 37 degrees C for 30 min in order to induce global ischemia. Then, the cortex is removed and homogenized, and the homogenate is subsequently exposed to air for 30 min for reoxygenation. Finally, the amount of thiobarbituric acid-reactive substances (TBAR) is measured. With this method, nisoldipine, nimodipine, nitrendipine, nifedipine and nicardipine were all shown to have an antioxidant activity that correlated with their lipophilicity, which was determined by their octanol/water partition coefficients.

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“…1982;Harper et a/. 1981;, but also as a n antagonist of thromboxane induced splanchnic vasoconstriction in traumatic shock (Lefer & Carrow 1981), whereas the parent compound nifedipine has been established as a general vasodilator (Mostbeck et a/. 1976 (1972 & 1977) selectively inhibit the transmembraneous slow channel influx of calcium ions and thereby exert a secondary negative effect o n the excitationcontraction coupling in smooth muscles and the myocardium.…”

mentioning

confidence: 99%

A Comparative Study of the Pharmacodynamic Effects of Nimodipine and Nifedipine in the Isolated Spontaneously Beating Rabbit Heart

Nielsen‐Kudsk

Askholt

Jensen

1983

Acta Pharmacologica et Toxicologica

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Myocardial effects of the calcium antagonistic drugs nimodipine and nifedipine were comparatively studied in retrogradely perfused rabbit hearts at stepwise increasing drug concentrations in the perfusion liquid within the range of 1–60 ng ml−1. Pharmacodynamic steady states developed slowly within about 25 min. at each concentration level. Nimodipine produced in comparison with nifedipine a progressive and very marked negative chronotropic effect and caused simultaneously a very pronounced increase in the QT‐interval. The potency of nimodipine with regard to these effects were about 10 times that of nifedipine. The PQ‐interval was only increased significantly at the two highest concentrations of nimodipine. Both drugs caused a pronounced inhibition of myocardial contractility as judged from the decrease in contraction amplitude and rate of contraction. Myocardial efficiency expressed as the ratio of contraction‐rate to oxygen consumption decreased progressively and highly significantly with increasing drug concentrations. The relative potency between nimodipine and nifedipine with regard to the negative inotropic effects was only about 1.7. Increasing exposure to nimodipine produced a progressive decrease of the mean coronary flow‐rate, whereas nifedipine initially caused an increase followed by a terminal decrease to the initial flow‐rate level.

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Salutary actions of nimodipine in traumatic shock

Cited by 14 publications

References 12 publications

Nimodipine

Nimodipine

Inhibition of lipid peroxidation by some dihydropyridine derivatives

A Comparative Study of the Pharmacodynamic Effects of Nimodipine and Nifedipine in the Isolated Spontaneously Beating Rabbit Heart

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