Salvage Cryotherapy Using an Argon Based System for Locally Recurrent Prostate Cancer After Radiation Therapy: The Columbia Experience

Ghafar, Mohamed A.; Johnson, Christopher W.; Taille, A. De La; Benson, Mitchell C.; Bagiella, Emilia; Fatal, Marie; Olsson, Carl A.; Katz, Aaron E.

doi:10.1016/s0022-5347(05)65763-1

Cited by 147 publications

(88 citation statements)

References 25 publications

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“…Gonder et al [6] were among the first to perform prostate cryoablation during surgery. Subsequently, with the advances introduced in cryosurgery and the availability of second-and thirdgeneration cryoablation technology, the idea of percutaneous image-guided cryoablation of prostate cancer emerged [7,8]. The first series of percutaneous ultrasound-guided prostate cryoablation was reported in 1993 by Onik et al [8].…”

Section: Introductionmentioning

confidence: 99%

Percutaneous MR-guided cryoablation of prostate cancer: initial experience

et al. 2012

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Section: Introductionmentioning

confidence: 99%

Percutaneous MR-guided cryoablation of prostate cancer: initial experience

et al. 2012

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“…However, as with repeat salvage HIFU, there is always concern of increased risk of fistula formation and incontinence. Published data in terms of DFS have achieved ranges from 11 to 73% at 5 years [30,31]. Data from our institution have shown a DFS rate at 10 years of between 39 and 64% with presalvage PSA <5 ng/ml and presalvage Gleason score ≤7 being the best predictor of disease-free recurrence at 10 years [32].…”

Section: Cryotherapymentioning

confidence: 89%

High-Intensity Focused Ultrasound and Cryotherapy as Salvage Treatment in Local Radio-Recurrent Prostate Cancer

2012

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Background: Salvage high-intensity focused ultrasound (HIFU) and cryotherapy (CRYO) have emerged as interesting alternatives in the treatment of local radio-recurrent prostate cancer. Currently, recommendations concerning the use of CRYO and HIFU in the salvage setting are still evolving. Aim: The objective of this review was to analyze the results from studies on CRYO and HIFU as salvage treatment in local radio-recurrent prostate cancer. Materials and Methods: A National Center for Biotechnology Information PubMed search (www.pubmed.gov) was conducted from 1993 to 2011 using medical subject headings ‘High-Intensity Focused Ultrasound’, ‘Cryotherapy’, ‘Local Radio-Recurrent’ and ‘Prostate Cancer’. Results: In the past years, there have been several published series demonstrating promising acceptable morbidity and oncological outcomes in the short term for HIFU and in the intermediate term for CRYO. The introduction of newer-generation devices and technical modifications has facilitated reduction of complications associated with the procedures. As with any salvage treatment, careful patient selection and subsequent follow-up are principal points. Conclusions: HIFU and CRYO are promising salvage treatments in patients with local radio-recurrent prostate cancer. The risk of significant complications in the salvage setting is higher compared with primary therapy; therefore, the patients must be informed about the risk of complications and the modality of treatment. However, only further evaluation in formal prospective clinical trials will hopefully confirm their role in clinical practice.

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“…Some centres have reported encouraging short term data, with biochemical recurrence-free survival up to 74% at 2 years. 6 In the intermediate term, however, a positive biopsy rate of 21%, 7 and a 5-year disease-free survival of 40% to 55% and 5-year disease specific survival of 79% has been reported. 8,9 Careful selection of patients is important for good outcomes.…”

Section: Discussionmentioning

confidence: 99%

The pattern of prostate cancer local recurrence after radiation and salvage cryoablation

Touma

Chalasani

et al. 2013

CUAJ

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Objective: We assessed the pattern of local recurrence after salvage cryoablation of the prostate, and the impact of local recurrence on intermediate-term outcome. Methods: One hundred twenty-two patients who underwent salvage cryoablation were studied after a mean follow-up of 56 months. Serial prostate biopsy was carried out after cryoablation. The histopathology of prostate biopsies before and after cryoablation were compared. The prognostic value of post-cryoablation biopsy was assessed with the Cox regression method. Results: 23.1% of patients had a positive biopsy for prostate cancer following salvage cryoablation. Most cancer recurrences occurred in the apex (51.5%), base (21.2%) and seminal vesicles (18.2%). The presence of cancer at the base of the prostate was found to be a prognostic factor for eventual biochemical failure. Overall 5-year biochemical disease-free survival (bDFS) was 28%, however patients with cancer at the base of the prostate had a 5-year bDFS of 0%. Conclusion: Cancer recurrences occurred in areas where aggressive freezing was avoided as it might result in serious problems (e.g., urethro-rectal fistula and incontinence). Post-cryoablation biopsies and the location of persistent disease are of prognostic value.

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Salvage Cryotherapy Using an Argon Based System for Locally Recurrent Prostate Cancer After Radiation Therapy: The Columbia Experience

Abstract: Our study supports cryosurgery of the prostate as safe and effective treatment in patients in whom radiation therapy fails. Using the CRYOCare machine resulted in a marked decrease in complications.

Cited by 147 publications

References 25 publications

Percutaneous MR-guided cryoablation of prostate cancer: initial experience

Percutaneous MR-guided cryoablation of prostate cancer: initial experience

High-Intensity Focused Ultrasound and Cryotherapy as Salvage Treatment in Local Radio-Recurrent Prostate Cancer

The pattern of prostate cancer local recurrence after radiation and salvage cryoablation

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