“…At this, many studies have demonstrated the effectiveness of interstitial BRT in the management of locally recurrent or secondary primary lesions, which develop within a previously irradiated volume [16,18,26,28,31,40,44].…”
“…At this, many studies have demonstrated the effectiveness of interstitial BRT in the management of locally recurrent or secondary primary lesions, which develop within a previously irradiated volume [16,18,26,28,31,40,44].…”
“…There was no apparent correlation between re-treatment dose and complication rate. Langlois et al (61) reported on a series of 123 patients re-treated between 1972 and 1984 for recurrence or new primary tumours of the tongue or oropharynx in previously irradiated areas. The total re-irradiation doses ranged from 31 to 84 Gy (mean 62 Gy), delivered in an average time of 12 days.…”
“…Although interstitial BT has been more widely used and established in cancers of the oropharynx 32,33,53,75,76 or PSC without invasion of the anterior skull base, 46 there are only a few reports specifically addressing BT application in PSC located at the anterior base of skull as shown in Tables 1 and 2. These efforts have in common that BT has been applied in combination with preceding tumor resection, so that consideration had to be given to whether a gross-total excision or tumor debulking can be accomplished and at what costs for surrounding structures.…”
Section: Psc With Extension Into the Skull Base And Orbitmentioning
confidence: 98%
“…[45][46][47][48][49][50][51][52][53][54][55] The exact placement of BT applicators is crucial for reliable dose distribution and by effective BT. There are many inherent difficulties of exact placement of BT applicators in the head and neck region because of its complex anatomic shape and bony structures.…”
Several approaches using perioperative brachytherapy (BT) in malignancies involving the skull base and/or orbit have evolved in the recent years. They include BT by seed implantation and BT in an afterloading technique. The benefit of perioperative BT in this management has been not yet defined. A systematic review of literature published in ''Medline'' and of own results was performed to analyze the role of BT in this regard, with special reference to orbital outcome.
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