Salvage of Sildenafil Failures Referred From Primary Care Physicians

Atiemo, Humphrey; Szostak, Michael J.; Sklar, Geoffrey N.

doi:10.1097/01.ju.0000096221.67967.ae

Cited by 75 publications

(54 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results confirmed by Atiemo et al [11]. Incorrect administration accounted for 81% of sildenafil failures referred by primary care physicians.…”

Section: Identifying Truly Treatment Failuressupporting

confidence: 81%

Treatment Options for Erectile Dysfunction in Patients Failing Oral Drug Therapy

Hatzimouratidis

Hatzichristou

2004

EAU Update Series

View full text Add to dashboard Cite

Oral drug therapy is the first line treatment for erectile dysfunction. Efficacy of oral drugs does not exceed 70%, while drop-out rate is high. Therefore, salvage strategies and second/third line treatment options are necessary to restore erectile function in such patients. The article reviews currently available data and comment on key issues that urologists address on their every day clinical practice.In order to do so, a literature-based critical presentation on the current methodological problems on definition of treatment failure, treatment outcome assessment and alternative therapeutic options was made.Emphasis was given in identifying truly non-responders, as proper instructions for oral drug administration and psychosexual counselling may reverse a substantial number of non-responders to responders. Medication, clinical and patient/partner related issues have been identify that may lead to treatment failure. Treatment outcome assessment based not only on quality of erectile response, but also on side effects profile and patient satisfaction is recommended. Treatment options for truly non-responders include intracavernosal injections, combination therapies, and penile prosthesis. Management strategy however, must identify patient and partner needs and expectations and involve them in the decision-making. #

show abstract

“…These results confirmed by Atiemo et al [11]. Incorrect administration accounted for 81% of sildenafil failures referred by primary care physicians.…”

Section: Identifying Truly Treatment Failuressupporting

confidence: 81%

Treatment Options for Erectile Dysfunction in Patients Failing Oral Drug Therapy

Hatzimouratidis

Hatzichristou

2004

EAU Update Series

View full text Add to dashboard Cite

show abstract

“…19 When these guidelines were followed, 74% of 111 consecutive men with ED who visited a urology clinic and were enrolled in a goal-oriented disease management program reported successful intercourse with sildenafil 50 or 100 mg, and 54% of 76 previous sildenafil nonresponders identified by retrospective chart review became responders. 76 The impact of reeducation and of titration to the maximum tolerated sildenafil dose is also supported by the results of Atiemo et al, 77 who reported a 42% (98/236) success rate in former sildenafil nonresponders, and by Jiann et al, 78 who reported a 59% (24/41) success rate in former sildenafil nonresponders. In these studies, incorrect administration (after heavy meals, lack of sexual stimulation, improper timing, too few attempts, and maximal dose o100 mg) was the most frequent cause for nonresponse to sildenafil.…”

Section: Optimizing Sildenafil Treatment To Maximize Effectivenesssupporting

confidence: 72%

Sildenafil citrate (Viagra) treatment for erectile dysfunction: an updated profile of response and effectiveness

Padma‐Nathan

2006

Int J Impot Res

View full text Add to dashboard Cite

In the 7 years since sildenafil citrate (VIAGRA) was introduced as the first oral phosphodiesterase type 5 inhibitor therapy for erectile dysfunction, it has been used to treat nearly 27 million men with erectile dysfunction worldwide. Patient populations with erectile dysfunction of varying etiologies and with diverse comorbidities have benefited from sildenafil treatment. This update focuses on relatively recent research that further defines the response and effectiveness profiles of sildenafil and provides additional insight into optimizing treatment. In addition to providing recent data on sildenafil efficacy and safety/tolerability, the update provides data on assessments of erection hardness, measures of psychosocial outcomes (e.g., emotional well-being and treatment satisfaction), and treatment approaches to maximize response and effectiveness (e.g., by titrating to the maximum tolerated dose). Increased understanding of the sildenafil response and effectiveness profiles and optimal sildenafil treatment are central to the appropriate management of erectile dysfunction using sildenafil.

show abstract

“…20 In all, 100 mg Sildenafil leads to an increase of adverse events such as blurred vision in 11.1%, compared with 2.2% for the dose of 50 mg. 21 Moreover, 40% of sildenafil nonresponders responded to the same dose after the re-education by ED specialists, including the timing of taking the drug or prevention of interaction with food. 22 Thus, 50 mg sildenafil administration with thorough education before prescription remains the mainstay for most Asian men to avoid undesirable complications. Although the definitive reason why Japanese men were satisfied with a lower dose is still unclear, the dose regulation of this country and the detailed information given about the administration of this drug might have affected the efficacy.…”

Section: Discussionmentioning

confidence: 99%

Outcome analysis of sildenafil citrate for erectile dysfunction of Japanese patients

et al. 2005

View full text Add to dashboard Cite

The approved maximal dose of sildenafil is only 50 mg in Japan, but the impact of dose regulation on treatment outcomes has not been established. Moreover, the contributors to the efficacy in patients having an intact peripheral nervous system have not been fully elucidated. We assessed in Japanese patients the treatment outcomes of sildenafil for erectile dysfunction (ED) under regulation of the approved dose and identified factors contributing to its efficacy among those with various etiologies other than pelvic surgery. We retrospectively reviewed 196 ED patients treated with sildenafil. The overall efficacy was 70.9% (139/196), and patients with psychological problems and concomitant cardiovascular disease showed high response rates (82.4 and 87.0%, respectively). Of the 139 responders, 89.9% achieved efficacy with a dose of 25 or 50 mg. Logistic regression analysis revealed concomitant cardiovascular disease and a favorable nocturnal penile tumescence result to be independent contributors to the efficacy.

show abstract

Salvage of Sildenafil Failures Referred From Primary Care Physicians

Cited by 75 publications

References 8 publications

Treatment Options for Erectile Dysfunction in Patients Failing Oral Drug Therapy

Treatment Options for Erectile Dysfunction in Patients Failing Oral Drug Therapy

Sildenafil citrate (Viagra) treatment for erectile dysfunction: an updated profile of response and effectiveness

Outcome analysis of sildenafil citrate for erectile dysfunction of Japanese patients

Contact Info

Product

Resources

About