Salvage photodynamic therapy accompanied by extended lymphadenectomy for advanced esophageal carcinoma: A case report

Nishida, Takahiro; Takeno, Shinsuke; Nakashima, Kenichiro; Kariya, Masato; Inatsu, Haruhiko; Kïtamura, Kazuo; Nanashima, Atsushi

doi:10.1016/j.ijscr.2017.05.025

Cited by 8 publications

(1 citation statement)

References 18 publications

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“…Over the past two decades, there was a slow but consistent understory of research and development of a large number of nanoparticles (NPs) in IBDs; NPs are polymeric fine units with at least one dimension up to 100 nm, which can be built to reach an intended target, be detected with a molecular imaging technique and further engineered to locally deploy a certain agent, with several mechanisms of activation including charge-mediated targeting, micro-environment triggered release targeting, and ligand-mediated targeting [79,80]. Nanomedicine combined with endoscopy has built up a solid background in ex vivo and in vivo preclinical settings, with minimal preliminary clinical data concerning esophageal and biliary cancers [79,81,82]; however, there is still no impact on clinical practice, in part due to safety concerns and heterogeneity of NPs, practical application, and study designs. The dual potential of NPs as drug-eluting and detectable nanovehicles represents an exciting perspective in IBD, potentially leading to dose-controlled and selective insite bioavailability of a drug or a therapeutic intervention targeting inflamed mucosa [83].…”

Section: New Techniques and Future Scenarios For Stenosis And Fibrosi...mentioning

confidence: 99%

Endoscopic Management of Strictures in Crohn’s Disease: An Unsolved Case

Coppola,

Principessa,

Di Vincenzo

et al. 2024

Preprint

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Crohn’s disease (CD) is a chronic inflammatory disease associated with a significant burden in terms of quality of life and health care costs and is frequently associated with several complications, including the development of intestinal strictures. Stricturing CD requires a careful multidisciplinary approach involving medical therapy and surgery, still posing a continuous management challenge; in this context, endoscopic treatment represents a valuable, in-between opportunity as a minimally invasive strategy, endorsed by extensive yet heterogeneous evidence and evolving research and techniques. This review summarizes current knowledge on the role of therapeutic endoscopy in stricturing CD, focusing on evidence gaps, recent updates, and novel techniques intended for optimizing efficacy, safety, and tailoring of this approach in the view of precision endoscopy.

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Section: New Techniques and Future Scenarios For Stenosis And Fibrosi...mentioning

confidence: 99%

Endoscopic Management of Strictures in Crohn’s Disease: An Unsolved Case

Coppola,

Principessa,

Di Vincenzo

et al. 2024

Preprint

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Primary esophageal cancer treated by esophagectomy with distal pancreatectomy: a report of three cases

Kurosaki

Hoshino

Kuwayama

et al. 2022

Clin J Gastroenterol

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Hysteroscopic Photodynamic Diagnosis Using 5-Aminolevulinic Acid: A High-Sensitivity Diagnostic Method for Uterine Endometrial Malignant Diseases

Matoba

Banno

Kisu

et al. 2020

Journal of Minimally Invasive Gynecology

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Study Objective: To examine the diagnostic accuracy of hysteroscopic photodynamic diagnosis (PDD) using 5-aminolevulinic acid (5ALA) in patients with endometrial cancer and premalignant atypical endometrial hyperplasia. Design: A single-center, open-label, exploratory intervention study. Setting: University Hospital in Japan. Patients: Thirty-four patients who underwent hysteroscopic resection in the Department of Obstetrics and Gynecology at Keio University Hospital.Interventions: Patients were given 5ALA orally approximately 3 hours before surgery and underwent observation of the uterine cavity and endometrial biopsy using 5ALA-PDD during hysteroscopic resection. Specimens were diagnosed histopathologically and the diagnostic sensitivity and specificity of hysteroscopic 5ALA-PDD for malignancy in the uterine cavity was determined. Red (R), blue (B), and green (G) intensity values were determined from PDD images, and the relationships of histopathological diagnosis with these values were used to develop a model for objective diagnosis of uterine malignancy. Measurements and Main Results: Three patients were excluded from the study because of failure of the endoscope system. A total of 113 specimens were collected endoscopically. The sensitivity and specificity of 5ALA-PDD for diagnosis of malignancy in the uterine cavity were 93.8% and 51.9%, respectively. The R/B ratio in imaging analysis was highest in malignant lesions, followed by benign lesions and normal uterine tissue, with significant differences among these groups (p <.05). The R/B and G/B ratios were used in a formula for prediction of malignancy based on logistic regression and the area under the receiver operating characteristic curve for this formula was 0.838. At a formula cutoff value of 0.220, the sensitivity and specificity for diagnosis of malignant disease were 90.6% and 65.4%, respectively. Conclusion: To our knowledge, this is the first study of the diagnostic accuracy of 5ALA-PDD for malignancies in the uterine cavity. Hysteroscopic 5ALA-PDD had higher sensitivity and identifiability of lesions. These findings suggest that hysteroscopic 5ALA-PDD may be useful for diagnosis of minute lesions.

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Salvage photodynamic therapy accompanied by extended lymphadenectomy for advanced esophageal carcinoma: A case report

Cited by 8 publications

References 18 publications

Endoscopic Management of Strictures in Crohn’s Disease: An Unsolved Case

Endoscopic Management of Strictures in Crohn’s Disease: An Unsolved Case

Primary esophageal cancer treated by esophagectomy with distal pancreatectomy: a report of three cases

Hysteroscopic Photodynamic Diagnosis Using 5-Aminolevulinic Acid: A High-Sensitivity Diagnostic Method for Uterine Endometrial Malignant Diseases

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