Salvage surgery after concomitant chemoradiation in head and neck squamous cell carcinomas—Stratification for postsalvage survival

Abstract

Salvage surgery after CCRT has acceptable outcomes. Initial stage IV tumors and concurrent local and regional failures were independent predictors that can stratify patients into distinct prognostic groups for postsalvage survival.

Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-and-Neck Cancer: Final Analysis of a Phase I/II Trial

“…Of the recurrent tumors, 22 (73%) were staged as rT3, rT4, or rN2 disease; 7 as rT2N0M0 cancer; and 1 nasopharyngeal cancer as rT1N0M0 disease. The mean of the longest tumor diameters before BNCT was 4.4 cm (range, 1.5-8.4 cm), the mean size of the GTV at irradiation planning was 99 cm 3 (range, 13-517 cm 3 ), and the mean size of the initial PTV was 257 cm 3 (range, 88-987 cm 3 ). Fifteen patients underwent 18 F-fluoro-L-BPA PET before BNCT.…”

“…Salvage surgery leads to durable disease control in 15% to 30% of the patients (1)(2)(3). When cancer is considered unresectable, the disease is almost uniformly fatal with a median survival time of only a few months (3,4).…”

“…Salvage surgery leads to durable disease control in 15% to 30% of the patients (1)(2)(3). When cancer is considered unresectable, the disease is almost uniformly fatal with a median survival time of only a few months (3,4). Palliative chemotherapy is regarded as a standard treatment, but full-dose, repeat irradiation is an option for selected patients and may result in durable control in approximately 10% of such patients (4)(5)(6)(7).…”

Salvage operations for patients with persistent or recurrent cancer of the maxillary sinus after superselective intra-arterial infusion of cisplatin with concurrent radiotherapy

“…The complication rate of salvage surgery after intensive chemoradiation therapy for patients with head and neck cancer was reported to be 11%-63.2% [7][8][9][10].…”

“…Salvage surgery is generally attempted, when localized persistent or recurrent primary tumors are observed after initial chemoradiotherapy [9][10][11][12]. However, there have been no reports of salvage surgery for patients with persistent/recurrent maxillary sinus cancer after intensive chemoradiotherapy to date.…”