Salvia cadmica: Phenolic composition and biological activity

Kocak, Mehmet Sefa; Sarıkürkçü, Cengiz; Cengiz, Mustafa; Kocak, Serpil; Uren, Mehmet Cemil; Tepe, Bektaş

doi:10.1016/j.indcrop.2016.03.015

Cited by 89 publications

(35 citation statements)

References 36 publications

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“…According to our present knowledge, no studies have been reported regarding phenolic compounds from S. microstegia , S. aethiopis and S. brachyantha in the open literature. However, there are other studies reporting phenolic compounds of different Salvia taxa [11,17,41,42]. …”

Section: Resultsmentioning

confidence: 99%

“…For instance a previous study revealed that Salvia chionantha possessed lower CUPRAC values than BHA and α-tocopherol [53]. As mentioned above, another factor affecting the antioxidant capacity is the selection of extraction solvent, for example, ethyl acetate extract of S. cadmica indicated a CUPRAC value that was almost a third of the one where methanol was used as extraction solvent [11]. …”

Section: Resultsmentioning

confidence: 99%

“…Having around 900 species around the world, Salvia L. belongs to the Lamiaceae family and is used in flavoring, cosmetics, perfumery, the pharmaceutical industries, and folk medicine [11]. Up until now, different Salvia species have been investigated for their biological activity including anti-inflammatory [12], antioxidant-antifungal [13], anticancer [14], as well as antiviral activities [15].…”

Section: Introductionmentioning

confidence: 99%

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RP-HPLC/MS/MS Analysis of the Phenolic Compounds, Antioxidant and Antimicrobial Activities of Salvia L. Species

et al. 2016

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The identification and quantification of the phenolic contents of methanolic extracts of three Salvia L. species namely S. brachyantha (Bordz.) Pobed, S. aethiopis L., and S. microstegia Boiss. and Bal. were evaluated using reverse phase high performance liquid chromatography, UV adsorption, and mass spectrometry (RP-HPLC/MS). In order to determine the antioxidant capacity of these species, cupric ions (Cu2+) reducing assay (CUPRAC) and ferric ions (Fe3+) reducing assay (FRAP) were performed to screen the reducing capacity and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay was employed for evaluation of the radical scavenging activity for both solvents. In further investigation, the antimicrobial activities of Salvia species were tested using the disc diffusion method against three Gram-positive and four Gram-negative microbial species, as well as three fungi species. The results showed that there is a total of 18 detectable phenols, the most abundant of which was kaempferol in S. microstegia and rosmarinic acids in S. brachyantha and S aethiopis. The other major phenols were found to be apigenin, luteolin, p-coumaric acid, and chlorogenic acid. All species tested showed moderate and lower antioxidant activity than standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and ascorbic acid. The ethanolic extracts of Salvia species revealed a wide range of antimicrobial activity. S. brachyantha and S. microstegia showed the highest antimicrobial activities against B. subtilis, whereas S. aethiopis was more effective on Y. lipolytica. None of the extracts showed anti-fungal activity against S. cerevisiae. Thus these species could be valuable due to their bioactive compounds.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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RP-HPLC/MS/MS Analysis of the Phenolic Compounds, Antioxidant and Antimicrobial Activities of Salvia L. Species

et al. 2016

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“…Also, a similar study investigated the antioxidant and enzyme inhibitory activity of Salvia cadmica Boiss against five enzymes (α‐amylase, α‐glucosidase, AChE, BChE, and tyrosinase). According to the results of that report, the plant extract showed only α‐amylase and α‐glucosidase inhibition (Kocak et al, ).…”

Section: Resultsmentioning

confidence: 98%

Phytochemical content, antioxidant activity, and enzyme inhibition effect ofSalvia eriophoraBoiss. & Kotschy against acetylcholinesterase, α-amylase, butyrylcholinesterase, and α-glycosidase enzymes

et al. 2019

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Many taxa of Salvia genus have been used in herbal beverages, food flavoring, cosmetics, and pharmaceutical industry. In this paper, chemical compounds of Salvia eriophora (S. eriophora) leaves were determined by LC–MS/MS (Liquid Chromatography tandem Mass Spectrometry). Salvigenin (158.64 ± 10.8 mg/kg), fumaric acid (123.09 ± 8.54 mg/kg), and quercetagetin‐3.6‐dimethylether (37.85 ± 7.09 mg/kg) were detected as major compounds in the ethanol extract, whereas fumaric acid (555.96 ± 38.56 mg/kg), caffeic acid (103.62 ± 20.51 mg/kg), and epicatechin (83.19 ± 8.43 mg/kg) were detected as major compounds in the water extract. Furthermore, enzyme inhibition of S. eriophora against acetylcholinesterase (AChE), α‐amylase (AM), butyrylcholinesterase (BChE), and α‐glycosidase (AG) enzymes were detected. AChE, BChE, AG, and AM enzymes were very strongly inhibited by S. eriophora water extract (WES) and S. eriophora methanol extract (MES). Additionally, antioxidant potential of S. eriophora was determined by in vitro analytical methods. IC50 values of WES and MES were performed for radicals. Practical applications Metabolic enzymes have crucial functions on living systems due to inhibition or activation of them mainly attributed with some health disorders. AChE, BChE, AM, and AG enzymes have important roles on carbohydrate metabolism or cholinergic pathways. The relation between enzyme inhibition effect and phenolic compounds or antioxidant activity need to be confirmed. Thus, many studies tested to clarify this relation for pure samples or plant extracts. To the best of our knowledge, this is the first report about inhibition effects of Salvia eriophora extracts against AChE, BChE, AM, and AG enzymes as well as their phenolic contents and antioxidant activities.

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“…Within O. natrix extracts, the methanol extract (1.53 mmolTE/g extract) exerted the strongest ability in phosphomolybdenum assay, followed by ethyl acetate (1.27 mmolTE/g extract) and water (1.13 mmolTE/g extract) extracts (Table 4 ). In the literature, several researchers reported different approaches for a correlation between total phenolic and the reduction of Mo (VI) to Mo (V) (Albayrak et al, 2010 ; Kocak et al, 2016 ; Amessis-Ouchemoukh et al, 2017 ). At this point, this activity for the methanol extract may be related to the presence of other antioxidants as well as phenolics.…”

Section: Resultsmentioning

confidence: 99%

A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis natrix subsp. hispanica

et al. 2017

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The genus Ononis has important value as traditional drugs and foods. In the present work, we aimed to assess the chemical profiles and biological effects of Ononis natrix subsp. hispanica extracts (ethyl acetate, methanol, and water). For chemical profile, total and individual phenolic components were detected. For biological effects, antioxidant (DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelating assays), enzyme inhibitory (against cholinesterase, tyrosinase, α-amylase and α-glucosidase), antimicrobial, DNA protection and cytotoxic abilities were tested. The predominant phenolics were apigenin, luteolin, and quercetin in the tested extracts. Generally, the ethyl acetate and methanol extracts were noted as the most active in the antioxidant and enzyme inhibitory assays. Water extract with different concentrations indicated high level of DNA protection activity. Methanol and ethyl acetate extracts showed antibacterial effect against to Staphylococcus aureus and Staphylococcus epidermidis strains. The cytotoxic effects of O. natrix subsp. hispanica extracts on the survival of HeLa and PC3 cells were determined by MTT cell viability assay. Water and methanol extracts caused initiation of apoptosis for PC3 cell line. Furthermore, molecular docking was performed to better understand interactions between dominant phenolic compounds and selected enzymes. Our results clearly indicate that O. natrix subsp. hispanica could be considered a potential candidate for designing novel pharmaceuticals, cosmeceuticals and nutraceuticals.

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Salvia cadmica: Phenolic composition and biological activity

Cited by 89 publications

References 36 publications

RP-HPLC/MS/MS Analysis of the Phenolic Compounds, Antioxidant and Antimicrobial Activities of Salvia L. Species

RP-HPLC/MS/MS Analysis of the Phenolic Compounds, Antioxidant and Antimicrobial Activities of Salvia L. Species

Phytochemical content, antioxidant activity, and enzyme inhibition effect ofSalvia eriophoraBoiss. & Kotschy against acetylcholinesterase, α-amylase, butyrylcholinesterase, and α-glycosidase enzymes

A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis natrix subsp. hispanica

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