Salvia officinalis essential oil extract attenuates cisplatin-induced hepatorenal damage via modulating oxidative stress and apoptosis.

Abstract

Cisplatin is one of the most powerful drugs used in cancer treatment, and it has several side effects, including hepatotoxicity and nephrotoxicity. This study aimed to see if Salvia officinalis essential oil extract (SOE) might protect rats' liver and kidneys against cisplatin damage. Twenty-four male albino rats were divided into 4 groups (6 rats each). G1 (control), G2 (SOE), G3 (cisplatin), and G4 (cisplatin+ SOE). Cisplatin-treated rats showed increased serum ALT, AST, ALP, cholesterol, triglyceride, LDL-cholesterol, creatinine, and urea concentrations and decreased total protein and albumin concentrations. Moreover, cisplatintreated rats significantly increased levels of MDA and decreased SOD and CAT levels in hepatic and renal tissue compared to the control group. SOE administration at a dose of 100mg SOE L./kg.b.wt. with once intraperitoneal (7.5 mg cisplatin/kg.b.wt.) on the 10th day of the experiment renormalized and reversed the hepatorenal damage induced by the cisplatin group due to its antioxidant and anti-inflammatory effects. Histopathological alteration and immunohistochemistry (TNF-alpha) examination showed improvement in the microscopic pictures of both the liver and kidneys after using SOE.