Salvianolic acid B, an antioxidant from Salvia miltiorrhiza, prevents Aβ25–35-induced reduction in BPRP in PC12 cells

Effects of Salvia miltiorrhiza on CNS Neuronal Injury and Degeneration: A Plausible Complementary Role of Tanshinones and Depsides

“…CTS is able to protect H9c2 cells against apoptosis induced by chronic hypoxia via acting on the mitochondrial apoptosis signalling pathway [52]. CTS can prevent chronic hypoxia by targeting the mitochondrial death pathway via balancing in anti-and proapoptotic proteins in the Bcl-2 family proteins, and by inhibitioning of mitochondria membrane hyperpolarization, cytochrome c translocation, caspase 3 activity, and inactivation of the HIF-1α protein [53]. The biochemical mechanisms related to CTS are summarized in l " Table 5.…”

“…This study showed that 15 µM Aβ [25][26][27][28][29][30][31][32][33][34][35] caused about 40 % additional LDH release from Aβ-treated cells compared with normal cells, and the cotreatment with SalB inhibited the LDH release from Aβ-treated cells. Lin and coworkers [53] investigated the neuroprotective effects of SalB on the expression of BPRP. Treatment of the PC12 cells with SalB significantly (p < 0.05) reversed the expression of BPRP and cell viability while it decreased ROS production and intracellular calcium.…”

Myocardium Protective Function of Salvianolic Acid B in Ischemia Reperfusion Rats

“…Salvianolic acid B (Sal B), a bioactive compound isolated from the Chinese herb Radix Salviae Miltiorrhizae, has been reported to exhibit anti-inflammatory and anti-oxidantive effects (Chen et al, 2011;Lin et al, 2006). As the most bioactive component of salvianolic acid extracted from Danshen, SalB shows higher free radical scavenging activity than vitamin C, and its antioxidant capacity is in agreement with its protective effects against cell injury from oxidative stresses (Zhao et al, 2008).…”

Potent effects of alkaloid-rich extract from Huperzia selago against sodium nitroprusside-evoked PC12 cells damage via attenuation of oxidative stress and apoptosis

“…This cell line exhibits unique sensitivity to oxidants and is widely used as a cellular model to study the mechanisms of oxidative stress and apoptosis, as well as a model for studying antioxidative and cytoprotective properties of various antioxidants [24,39,41]. For example, studies on PC12 cells have shown that amyloidogenic proteins, Ab and ASN induce cytotoxicity and also elicit excessive free radical production [1,11,18], mitochondrial dysfunction [11], apoptosis and cell death [20]. Here, we demonstrate that AFs prevent or at least markedly attenuate SNP-induced oxidative stress and protect PC12 cells from ROS-induced injury.…”