Salvianolic Acid B inhibits platelet adhesion under conditions of flow by a mechanism involving the collagen receptor α2β1

Wu, Ya Ping; Zhao, Xiao Min; Pan, Shao Dong; Guo, Di; Wei, Rongrong; Han, Jinmin; Kainoh, Mie; Xia, Zuo Li; Groot, Philip G. de; Lisman, Ton

doi:10.1016/j.thromres.2008.05.020

Cited by 43 publications

(26 citation statements)

References 21 publications

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“…There is an accumulation of evidence that Sal B may exert cardiovascular protecting effects through inhibition of oxidative stress [17] and lipid peroxidation [18], reducing the generation of ROS, increasing the release of NO, inhibition of platelet aggregation and adhesion [19], anti-inflammatory activity [20] and suppression of apoptosis induced by other factors. Thus, although there is still no direct evidence of Sal B involved in modulating lipid metabolism and improving dyslipidemia, we want to know whether Sal B could improve the cholesterol transport.…”

Section: Discussionmentioning

confidence: 99%

Salvianolic acid B accelerated ABCA1-dependent cholesterol efflux by targeting PPAR-γ and LXRα

Yue

Jing

et al. 2015

Biochemical and Biophysical Research Communications

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Section: Discussionmentioning

confidence: 99%

Salvianolic acid B accelerated ABCA1-dependent cholesterol efflux by targeting PPAR-γ and LXRα

Yue

Jing

et al. 2015

Biochemical and Biophysical Research Communications

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“…Eight derivatives of Danshen inhibit platelet aggregation induced by adenosine diphosphate (ADP) in vitro in rabbit plasma [29]. Salvianolic acid B (SAB) inhibits platelet deposition to collagen at venous and arterial shear rates, suggesting that SAB inhibits platelet adhesion to collagen via interfering collagen receptor α2β1 [30]. Salvianolic acid inhibits ADP-induced platelet aggregation in platelet-rich plasma and in washed platelets both in vivo and in vitro , probably through changing protein expression [31].…”

Section: Reviewmentioning

confidence: 99%

Pharmacological effects of Salvia miltiorrhiza (Danshen) on cerebral infarction

Lin

Hsieh

2010

Chinese Medicine

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Danshen, the dried root of Salvia miltiorrhiza, is a Chinese medicine used to promote blood flow and treat vascular disease. The present article reviews the pharmacological effects of Danshen on cerebral infarction and possible interactions between Danshen and Western drugs. Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggregation effects, which prevent cerebral infarction. Danshen may enhance endogenous anti-oxidative enzyme activities such as the expression of endothelial nitric oxide synthase and may scavenge oxygen free radicals. Prevention and treatment of cerebral infarction by Danshen involves multiple pathways, including anti-atherosclerosis, anti-hypertension, anti-platelet aggregation, anti-inflammatory and anti-oxidative effects.

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“…The major effective components of the extracts included Salvianolic acid B, TanshinoneIIA and Andrographolide, which are considered to have biological effects in vascular disease. Previous studies have reported that Salvianolic acid B inhibits platelet adhesion to collagen, and does so by interfering with the function of collagen receptor α2β1 [18], regulating lipid metabolism by inhibiting CD36 expression [19] and via oxidative modification of low density lipoprotein (LDL). In addition, TanshinoneIIA can promote blood flow by inhibiting platelet aggregation [20] and activation [21], and reducing thrombus formation [22].…”

Section: Discussionmentioning

confidence: 99%

Effects of Shenlian extract on experimental atherosclerosis in ApoE-deficient mice based on ultrasound biomicroscopy

Guo

Liu

Wang

et al. 2016

BMC Complement Altern Med

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BackgroundThis study directly and dynamically investigated the effects of SL extract (i.e., a combination of Radix Salviae miltiorrhizae and Andrographis paniculata extract) on plaque progression in vivo by high resolution ultrasound biomicroscopy (UBM).MethodsAn atherosclerosis model was established by placing a perivascular collar on the right common carotid artery in apolipoprotein E-deficient (ApoE-/-) mice. Thickness, plaque area and local blood flow were observed by UBM, pathological changes were observed by histochemical staining, and lipid levels were measured by respective commercially available kits.ResultsCompared with the model group, the SL extract groups showed reduced wall thickness of the aortic arch (GC: P = 0.001, P = 0.002, and P < 0.001; LC: P < 0.001, P < 0.001, and P < 0.001; BC: P = 0.027, P = 0.017, and P = 0.003; respectively), which presented with retarded plaque progression of the cartoid artery with concordantly increased blood flow (P = 0.002 and P < 0.001) as visualized in vivo by UBM. Histological analysis confirmed the reduction of carotid atherosclerosis.ConclusionsThe SL extract inhibited the formation of atherosclerotic plaques in an ApoE-/- mice model by UBM analysis, and did so by effects that ameliorated local blood flow and improved blood lipid levels.

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Salvianolic Acid B inhibits platelet adhesion under conditions of flow by a mechanism involving the collagen receptor α2β1

Cited by 43 publications

References 21 publications

Salvianolic acid B accelerated ABCA1-dependent cholesterol efflux by targeting PPAR-γ and LXRα

Salvianolic acid B accelerated ABCA1-dependent cholesterol efflux by targeting PPAR-γ and LXRα

Pharmacological effects of Salvia miltiorrhiza (Danshen) on cerebral infarction

Effects of Shenlian extract on experimental atherosclerosis in ApoE-deficient mice based on ultrasound biomicroscopy

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