Salvianolic acid B protects against acute lung injury by decreasing TRPM6 and TRPM7 expressions in a rat model of sepsis

Yang, Chuwei; Liu, Hui; Li, Xiangdong; Sui, Shaoguang; Liu, Yu-Fei

doi:10.1002/jcb.26233

Cited by 29 publications

(17 citation statements)

References 34 publications

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“…During acute lung injury (ALI), the permeability of the alveolar-capillary membrane is increased, which in turn can lead to migration of neutrophils [ 60 ]. A septic rat model treated with salvianolic B showed that sepsis-induced ALI was reduced due to decreased levels of TRMP6 and TRPM7 mRNA in lung tissue, potentially linking TRPM7 to neutrophil migration and infiltration [ 61 ]. As patients with inherited neutrophil deficiencies suffer from severe infections that are often fatal, underscoring the importance of this cell type in immune defence, it is critical to gain a better understanding of the role of TRPM7 channel and kinase activities in the signalling cascades triggering neutrophil migration [ 53 ].…”

Section: The Channel-kinase Trpm7 In Immune Cell Signallingmentioning

confidence: 99%

The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis

Nadolni¹,

Zierler²

2018

Cells

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The enzyme-coupled transient receptor potential channel subfamily M member 7, TRPM7, has been associated with immunity and immune cell signalling. Here, we review the role of this remarkable signalling protein in lymphocyte proliferation, differentiation, activation and survival. We also discuss its role in mast cell, neutrophil and macrophage function and highlight the potential of TRPM7 to regulate immune system homeostasis. Further, we shed light on how the cellular signalling cascades involving TRPM7 channel and/or kinase activity culminate in pathologies as diverse as allergic hypersensitivity, arterial thrombosis and graft versus host disease (GVHD), stressing the need for TRPM7 specific pharmacological modulators.

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Section: The Channel-kinase Trpm7 In Immune Cell Signallingmentioning

confidence: 99%

The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis

Nadolni¹,

Zierler²

2018

Cells

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“…Previous studies have indicated that SalB exhibits various biological activities, including anti-inflammatory and anti-oxidative effects (11,12). In addition, SalB has been reported to attenuate the induction of lung injury by sepsis (13). However, whether SalB has a protective effect against sepsis-induced liver injury remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Salvianolic acid�B protects against sepsis‑induced liver injury via activation of SIRT1/PGC‑1α signaling

Guo

et al. 2020

Exp Ther Med

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Liver injury occurs frequently during sepsis, which leads to high mortality and morbidity. A previous study has suggested that salvianolic acid B (SalB) is protective against sepsis-induced lung injury. However, whether SalB is able to protect against sepsis-induced liver injury remains unclear. The present study aimed to investigate the effects of SalB on sepsis-induced liver injury and its potential underlying mechanisms. Sepsis was induced in mice using a cecal ligation and puncture (CLP) method. The mice were treated with SalB (30 mg/kg intraperitoneally) at 0.5, 2 and 8 h after CLP induction. Pathological alterations of the liver were assessed using hematoxylin and eosin staining. The serum levels of alanine transaminase (ALT), aspartate aminotransferase (AST), tumor necrosis factor (TNF)-α and interleukin (IL)-6 were measured. The hepatic mRNA levels of TNF-α, IL-6, Bax and Bcl-2 were also detected. The results suggested that treatment with SalB ameliorated sepsis-induced liver injury in the mice, as supported by the mitigated pathologic changes and lowered serum aminotransferase levels. SalB also decreased the levels of the inflammatory cytokines TNF-α and IL-6 in the serum and the liver of the CLP model mice. In addition, SalB significantly downregulated Bax expression and upregulated Bcl-2 expression, and upregulated the expression levels of SIRT1 and PGC-1α. However, when sirtuin 1 (SIRT1) small interfering RNA was co-administered with SalB, the protective effects of SalB were attenuated and the expression levels of SIRT1 and PGC-1α were reduced. In summary, these results indicate that SalB mitigates sepsis-induced liver injury via reduction of the inflammatory response and hepatic apoptosis, and the underlying mechanism may be associated with the activation of SIRT1/PGC-1α signaling.

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Section: Introductionmentioning

confidence: 99%

“…Sal B, as the most abundant and active component of SMPA (Jin, Zhang, Li, Liang, & Jia, ), also plays an important role in the prevention and treatment of various lung diseases (Lin et al, ; Yang, Liu, Li, Sui, & Liu, ; Zhang, Zhang, & Li, ). Sal B can reduce the exudation of alveolar capillary albumin, inhibit the wet/dry ratio of lung tissue to improve pulmonary edema, inhibit the release of inflammatory factors TNF‐ α and IL‐8 in alveolar lavage fluid and inhibit the inflammatory cells from blood vessels to lung tissue to alleviate inflammatory injury in lung (Lin et al, ; Yang et al, ; Zhang et al, ). Ros A has many biological activities such as anti‐inflammatory (Osakabe, ), anti‐oxidation (Qiao et al, ; Sui et al, ), anti‐apoptosis (Kim et al, ), anti‐fibrosis (Li et al, ), photoprotection of keratinocytes (Psotova, Svobodova, Kolarova, & Walterova, ), prevention of Alzheimer's disease (Hamaguchi, Ono, Murase, & Yamada, ) and neuroprotection (Fallarini et al, ), which are beneficial in the treatment of idiopathic pulmonary fibrosis (IPF).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of salvianolic acid B, rosmarinic acid and Danshensu in rat after pulmonary administration of Salvia miltiorrhiza polyphenolic acid solution

Lü

Xing

Xue

et al. 2019

Biomedical Chromatography

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A sensitive and accurate LC-MS/MS method was established for quantifying salvianolic acid B (Sal B), rosmarinic acid (Ros A) and Danshensu (DA) in rat plasma. Salvia miltiorrhiza polyphenolic acid (SMPA), active water-soluble ingredients isolated and purified from Salvia miltiorrhiza Bge included Sal B, Ros A and DA. The pharmacokinetic analysis of Sal B, Ros A and DA after pulmonary administration of SMPA solution to rat was performed by LC-MS/MS. Results from the pharmacokinetic studies showed that the peak concentration of DA was 21.85 ± 6.43 and 65.39 ± 3.83 ng/ mL after pulmonary and intravenous administration, respectively. DA was not detected at 2 h after administration. The absolute bioavailabilities of Sal B and Ros A were respectively 50.37 ± 27.04 and 89.63 ± 12.16% after pulmonary administration of 10 mg/kg SMPA solution in rats. The absolute bioavailability of Sal B increased at least 10-fold after pulmonary administration, compared with oral administration. It was concluded that the newly established LC-MS/MS method was suitable for describing the pharmacokinetic characteristics of Sal B, Ros A and DA in rat after pulmonary administration of SMPA solution. The data from this study will provide a preclinical insight into the feasibility of pulmonary administration of SMPA. KEYWORDS LC-MS/MS, pharmacokinetics, pulmonary administration, Salvia miltiorrhiza polyphenolic acid

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Salvianolic acid B protects against acute lung injury by decreasing TRPM6 and TRPM7 expressions in a rat model of sepsis

Cited by 29 publications

References 34 publications

The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis

The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis

Salvianolic acid�B protects against sepsis‑induced liver injury via activation of SIRT1/PGC‑1α signaling

Pharmacokinetics of salvianolic acid B, rosmarinic acid and Danshensu in rat after pulmonary administration of Salvia miltiorrhiza polyphenolic acid solution

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