Salvinorin A Inhibits Airway Hyperreactivity Induced by Ovalbumin Sensitization

Rossi, Antonietta; Caiazzo, Elisabetta; Bilancia, Rossella; Riemma, Maria Antonietta; Pagano, Ester; Cicala, Carla; Ialenti, Armando; Zjawiony, Jordan K.; Izzo, Angelo A.; Capasso, Raffaele; Roviezzo, Fiorentina

doi:10.3389/fphar.2016.00525

Cited by 25 publications

(29 citation statements)

References 38 publications

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“…It has been used for human growth and development and prevention of diseases . So far, several therapeutic activities such as antioxidant, anti‐inflammatory, anticonvulsant and relaxant effects have been shown for ALA. Salvinorin A (C 23 H 28 O 8 ) also reduced airway hyperreactivity and interleukin (IL) 13 and inhibited mast cell degranulation but was not effective against pulmonary inflammation, or IL‐4, IgE and leukotriene C4 levels in the lung of sensitized mice . It was also reported that palmitoylethanolamide (PEA, C 18 H 37 NO 2 ), which is coreleased with endocannabinoid anandamide, was reduced in the bronchi of OVA‐sensitized animals and this observation was significantly associated with upregulation of cannabinoid (CB2) and G protein‐coupled receptor 55 (GPR55) receptors.…”

Section: Introductionmentioning

confidence: 99%

Alpha-linolenic acid ameliorates bronchial asthma features in ovalbumin-sensitized rats

Boskabady

Kaveh

Shakeri

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Effect of alpha-linolenic acid (ALA) against ovalbumin (OVA)induced inflammation, oxidant/antioxidant imbalance and pathological features was examined in rat. Methods Total and differential WBC count and oxidant/antioxidant levels in BALF (bronchoalveolar lavage fluid) as well as lung pathological features were investigated in five groups of rats including controls (group C), rats sensitized with OVA (group S) and S treated with either ALA (0.2 and 0.4 mg/ml) or dexamethasone. Key findings As compared to group C, in OVA-sensitized rats, increases in WBC counts, levels of oxidant biomarkers and most pathological scores were observed while lymphocyte percentage and antioxidants levels decreased. Treatment with ALA (0.2 and 0.4 mg/ml) significantly reduced total WBC, NO 2 and NO 3 levels, interstitial fibrosis and emphysema compared to sensitized group. The higher dose of ALA also significantly decreased neutrophil, eosinophil, and monocyte counts, MDA levels and interstitial inflammation but increased lymphocyte counts, as well as antioxidants levels, compared to sensitized group. Dexamethasone administration led to a significant improvement of most factors compared to group S but had no effects on total WBC count, bleeding and epithelial damage. Conclusions Alpha-linolenic acid suppressed inflammation and oxidative stress, making it a potential therapeutic candidate for treatment of airway inflammatory diseases such as bronchial asthma.

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Section: Introductionmentioning

confidence: 99%

Alpha-linolenic acid ameliorates bronchial asthma features in ovalbumin-sensitized rats

Boskabady

Kaveh

Shakeri

et al. 2019

Journal of Pharmacy and Pharmacology

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“…It is a commonly held view that the disordered airway physiology and airway remodeling characteristics of asthma are consequences of airway inflammation and cell infiltration that is typically eosinophilic. In order to assess the role of PEA on eosinophil infiltration we chose the model of allergen-induced eosinophil extravasation into mouse air-pouches ( Figure 4A ) ( Das et al, 1997 ; Rossi et al, 2016 ). Specifically, air pouch provides a convenient cavity from which cells and mediators can be easily harvested.…”

Section: Resultsmentioning

confidence: 99%

Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse

et al. 2017

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One important risk factor for the development of asthma is allergen sensitization. Recent increasing evidence suggests a prominent role of mast cells in asthma pathophysiology. Since Palmitoylethanolamide (PEA), an endogenous lipid mediator chemically related to – and co-released with- the endocannabinoid anandamide, behaves as a local autacoid down-regulator of mast cell activation and inflammation, we explored the possible contribution of PEA in allergic sensitization, by using ovalbumin (OVA) as sensitizing agent in the mouse. PEA levels were dramatically reduced in the bronchi of OVA-treated animals. This effect was coupled to a significant up-regulation of CB2 and GPR55 receptors, two of the proposed molecular PEA targets, in bronchi harvested from allergen-sensitized mice. PEA supplementation (10 mg/kg, 15 min before each allergen exposure) prevented OVA-induced bronchial hyperreactivity, but it did not affect IgE plasma increase. On the other hand, PEA abrogated allergen-induced cell recruitment as well as pulmonary inflammation. Evaluation of pulmonary sections evidenced a significant inhibitory action of PEA on pulmonary mast cell recruitment and degranulation, an effect coupled to a reduction of leukotriene C4 production. These findings demonstrate that allergen sensitization negatively affects PEA bronchial levels and suggest that its supplementation has the potential to prevent the development of asthma-like features.

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“…Many previous studies showed that lung tissues accumulate excessive amounts of the inflammatory cytokines, TNF-α and IL-6, which cause damage to lung cells, and might also induce the development of lung fibrosis [33,34]. In addition, allergens and inflammatory cytokines were shown to stimulate an inflammatory response in tracheal epithelial cells and increase lung tissue damage caused by inflammation [25,35,36]. The present study demonstrated that sesamol could attenuate the inflammatory response in TNF-α/IL-4-stimulated tracheal epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Sesamol Alleviates Airway Hyperresponsiveness and Oxidative Stress in Asthmatic Mice

Liou

Chen

et al. 2020

Antioxidants

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Sesamol, isolated from sesame seeds (Sesamum indicum), was previously shown to have antioxidative, anti-inflammatory, and anti-tumor effects. Sesamol also inhibited lipopolysaccharide (LPS)-induced pulmonary inflammatory response in rats. However, it remains unclear how sesamol regulates airway inflammation and oxidative stress in asthmatic mice. This study aimed to investigate the efficacy of sesamol on oxidative stress and airway inflammation in asthmatic mice and tracheal epithelial cells. BALB/c mice were sensitized with ovalbumin, and received oral sesamol on days 14 to 27. Furthermore, BEAS-2B human bronchial epithelial cells were treated with sesamol to investigate inflammatory cytokine levels and oxidative responses in vitro. Our results demonstrated that oral sesamol administration significantly suppressed eosinophil infiltration in the lung, airway hyperresponsiveness, and T helper 2 cell-associated (Th2) cytokine expressions in bronchoalveolar lavage fluid and the lungs. Sesamol also significantly increased glutathione expression and reduced malondialdehyde levels in the lungs of asthmatic mice. We also found that sesamol significantly reduced proinflammatory cytokine levels and eotaxin in inflammatory BEAS-2B cells. Moreover, sesamol alleviated reactive oxygen species formation, and suppressed intercellular cell adhesion molecule-1 (ICAM-1) expression, which reduced monocyte cell adherence. We demonstrated that sesamol showed potential as a therapeutic agent for improving asthma.

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Salvinorin A Inhibits Airway Hyperreactivity Induced by Ovalbumin Sensitization

Cited by 25 publications

References 38 publications

Alpha-linolenic acid ameliorates bronchial asthma features in ovalbumin-sensitized rats

Alpha-linolenic acid ameliorates bronchial asthma features in ovalbumin-sensitized rats

Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse

Sesamol Alleviates Airway Hyperresponsiveness and Oxidative Stress in Asthmatic Mice

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