Samarium-Mediated Asymmetric Synthesis

Abstract

Samarium is an efficient reducing agent, a radical generator in cyclization and a cascade addition reaction. Interestingly, samarium metal has crucial impact on numerous C-C and C-X (X = hetero atom) bond forming transformations. It has been established as an exceptional chemo-selective and stereoselective reagent. The reactivity of the samarium catalyst/reagent is remarkably enhanced in the presence of various additives, ligands and solvents through effective coordination and an increase in reduction potential. It has inherent character to act as electron donor for a wide range of transformations including the asymmetric version of various reactions. This review accentuates the developments in samarium-mediated/catalyzed asymmetric organic synthesis over the past 12 years, where the chirality has been induced from ligand, a nearby asymmetric center within the substrate or through coordination directed stereospecific reactions.

Cu(II)‐Catalyzed Green Synthesis of 1,4,5‐Trisubstituted‐1,2,3‐Triazoles from Chalcone Derivatives – Studies on Their Cytotoxicity Profile

“…Numerous N ‐heterocyclic compounds have been extensively synthesized due to their widespread utility in medicinal, sensing and catalytic applications [1–4] . A subtle change in the electronic and steric properties of remote substituents in the molecules can modify the structural and binding properties when they are associated with the biological substrates [5,6] . It is always imperative to design and synthesize new molecules of such useful N ‐heterocyclic compounds required for the applications [7,8] .…”