Sambucus nigra L. leaves inhibit TNF-α secretion by LPS-stimulated human neutrophils and strongly scavenge reactive oxygen species

Skowrońska, Weronika; Granica, Sebastian; Czerwińska, Monika E.; Osińska, Ewa; Bazylko, Agnieszka

doi:10.1016/j.jep.2022.115116

Cited by 10 publications

(19 citation statements)

References 40 publications

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“…E 2 registered statistically significant (p < 0.05), the highest DPPH radical scavenging activity (93.5 ± 11.09 %) at the tested concentration of 125 μg mL -1 . Our results are in agreement with previous studies on S. nigra biological activity showing that aqueous and ethanolic extracts of S. nigra leaves and fruits strongly scavenge ROS and inhibit LOX [13,14]. The increased antioxidant activity of E 2 and E 1 creams is directly related to the stable DPPH / R inhibition of the applied S. nigra extracts, especially the use of S. nigra fresh juice, more potent than ascorbic acid [13,14,22,25].…”

Section: Increased Lipoxygenase and In Vitro Antioxidant Activity Of ...supporting

confidence: 92%

“…Enzyme inhibition, antioxidant activity, and lipid peroxidation of emulsions for 100 μL (125 μg mL -1 ) sample of E 1 /b, E 1 , E 2 /b, and E 2 were determined by: a) inhibition of lipoxygenase (LOX; 7126.1 U mL -1 ) [13,14] in positive control -indomethacin and absorption 234 nm; b) the DPPH/ R analysis (0.02 mM) after 30 min incubation, absorbance -518 nm with positive control -ascorbic acid [14,15]; c) Scavenging of superoxide (•O 2…”

Section: Determination Of Lipoxygenase Antioxidant Activity In Vitro ...mentioning

confidence: 99%

“…) anion radicals in xanthine-xanthine oxidase (xanthine 0.5 mM/ PBS; 1:1v/v; NBT 0.16 mM/ PBS; xanthine oxidase 3.92 mU/ PBS) system [14,16] at absorption 560 nm, with positive controlascorbic acid; d) H 2 O 2 inhibition (50 μL peroxidase / PBS; 50 μL H 2 O 2 (0.007 %) and 50 μL / PBS luminol (0.005 μg mL -1 ) [14,16] was run on positive control -ascorbic acid; f) NO (nitric oxide) activity [17] with a positive control -ascorbic acid, performed at absorption 546 nm; f) EPR -Bruker ER -116 -DS measurement of lipid peroxidation [18] against phenyl N -tert -butylnitrone (PBN/ DMSO; 5:0.04 mM) against the PBN/ DMSO standard.…”

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confidence: 99%

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Antibacterial and Antioxidant Activity of Cosmetic Creams With Extracts of Dry Flowers and Fruits of Sambucus Nigra L. - Use of Sambucus Nigra L. As a Non-Traditional Chemical Preservative

Petkova - Parlapanska,

Handzhiyski,

Georgieva

et al. 2024

JCTM

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Natural ingredients rich in antioxidants and polyphenols in the forme of extracts, essential oils, organic acids have been used in the production of different cosmetic products. In the development of new cosmetic compositions, or the improvement of products already implemented in production, the evaluation of the user is of great importance, as it directly affects the demand for a given product. The present study aimed to produce phytocosmetic creams based on stearic acid with extracts of dry flower and fruit juice of Sambucus nigra L. (S. nigra) and to investigatein parallel their potential as substitutes for conventional preservatives. The obtained creams were determined for minimum inhibitory, and minimum bactericidal activity using three bacterial strains (Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC25923, Bacillus subtilis ATCC 6633). In addition, the antibacterial effect of creams against Escherichia coli (BW 28357) was determined. In our experiments we found that addition of dried flower extracts or elderberry fruit extracts from S. nigra in the emulsion does not disturb the compositional system. In conclusion, according to the results, the Sambucus nigra L. extracts from dry flowers and elderberry fruitsare appropriate for use in cosmetic emulsions that demonstated antioxidant stability and antibacterial properties.

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Section: Increased Lipoxygenase and In Vitro Antioxidant Activity Of ...supporting

confidence: 92%

Section: Determination Of Lipoxygenase Antioxidant Activity In Vitro ...mentioning

confidence: 99%

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confidence: 99%

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Antibacterial and Antioxidant Activity of Cosmetic Creams With Extracts of Dry Flowers and Fruits of Sambucus Nigra L. - Use of Sambucus Nigra L. As a Non-Traditional Chemical Preservative

Petkova - Parlapanska,

Handzhiyski,

Georgieva

et al. 2024

JCTM

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“…As it is commonly accepted that atherosclerosis is an inflammatory disease, elder leaves and flowers may contribute to atheroprotection not only by the reduction of foam cell formation, but also through reduction of inflammation. Interestingly, elder leaves in fact possess anti-inflammatory activity in human neutrophils 34 . Further, elder was shown to improve HDL function and ameliorate atherosclerosis in mice 35 , 36 .…”

Section: Discussionmentioning

confidence: 99%

Elder (Sambucus nigra), identified by high-content screening, counteracts foam cell formation without promoting hepatic lipogenesis

Steinbauer,

König,

Neuhauser

et al. 2024

Sci Rep

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Cholesterol deposition in intimal macrophages leads to foam cell formation and atherosclerosis. Reverse cholesterol transport (RCT), initiated by efflux of excess cholesterol from foam cells, counteracts atherosclerosis. However, targeting RCT by enhancing cholesterol efflux was so far accompanied by adverse hepatic lipogenesis. Here, we aimed to identify novel natural enhancers of macrophage cholesterol efflux suitable for the prevention of atherosclerosis. Plant extracts of an open-access library were screened for their capacity to increase cholesterol efflux in RAW264.7 macrophages trace-labeled with fluorescent BODIPY-cholesterol. Incremental functional validation of hits yielded two final extracts, elder (Sambucus nigra) and bitter orange (Citrus aurantium L.) that induced ATP binding cassette transporter A1 (ABCA1) expression and reduced cholesteryl ester accumulation in aggregated LDL-induced foam cells. Aqueous elder extracts were subsequently prepared in-house and both, flower and leaf extracts increased ABCA1 mRNA and protein expression in human THP-1 macrophages, while lipogenic gene expression in hepatocyte-derived cells was not induced. Chlorogenic acid isomers and the quercetin glycoside rutin were identified as the main polyphenols in elder extracts with putative biological action. In summary, elder flower and leaf extracts increase macrophage ABCA1 expression and reduce foam cell formation without adversely affecting hepatic lipogenesis.

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“…Popova et al analyzed the effects of a cream containing extracts of Pelargonium sidoides, S. nigra, and Hypericum perforatum on different microbes, resulting in a high antimicrobial effect against C. albicans, E. coli, and S. aureus [101]. Concerning the positive effect of S. nigra on inflammation, aqueous and ethanolic black elder leaf extracts showed a high anti-inflammatory potential by inhibition of TNF-α and reactive oxygen species [102]. Furthermore, an aqueous black elder fruit extract and its ferment were investigated concerning their anti-inflammatory and antioxidant activity as well as their impact on fibroblasts and keratinocytes.…”

Section: Sambucus Spmentioning

confidence: 99%

VOLKSMED Database: A Source for Forgotten Wound Healing Plants in Austrian Folk Medicine

Eichenauer,

Saukel,

Glasl

2024

Planta Med

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The global increase in the incidence of wounds is concerning and fuels the search for new treatment options. The use of traditional medicinal plants in wound healing represents an appreciated available therapeutic possibility. This work introduces the VOLKSMED database, which contains plants and other materials used in Austrian folk medicine, either as monographs or mixtures. This work focuses on the monographs of the database. Concerning wound healing, Hypericum sp., Arnica montana, Calendula officinalis, Plantago sp., and Malva sp. are the most commonly used plants. The focus of this paper is set on selected lesser-known plants (Abies alba, Anthyllis vulneraria, Brassica sp., Gentiana sp., Larix decidua, Picea abies, Sambucus sp., Sanicula europaea) and their status quo in literature concerning wound healing. A systematic search using the databases SciFinder, SCOPUS, and PubMed yielded substantial evidence for the wound healing potential of Brassica sp., Gentiana sp., the Pinaceae A. abies, L. decidua, and P. abies, as well as Sambucus nigra. In vivo and clinical studies substantiate their use in Austrian folk medicine. According to the literature, especially A. vulneraria, Sambucus racemosa, and S. europaea would be worth investigating in-depth since data concerning their wound healing effects – even though scarce – are convincing. In conclusion, the VOLKSMED database contains promising opportunities for further treatment options in the field of wound healing. Future research should consider the listed plants to support their traditional use in Austrian folk medicine and possibly promote the implementation of old knowledge in modern medicine.

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Sambucus nigra L. leaves inhibit TNF-α secretion by LPS-stimulated human neutrophils and strongly scavenge reactive oxygen species

Cited by 10 publications

References 40 publications

Antibacterial and Antioxidant Activity of Cosmetic Creams With Extracts of Dry Flowers and Fruits of Sambucus Nigra L. - Use of Sambucus Nigra L. As a Non-Traditional Chemical Preservative

Antibacterial and Antioxidant Activity of Cosmetic Creams With Extracts of Dry Flowers and Fruits of Sambucus Nigra L. - Use of Sambucus Nigra L. As a Non-Traditional Chemical Preservative

Elder (Sambucus nigra), identified by high-content screening, counteracts foam cell formation without promoting hepatic lipogenesis

VOLKSMED Database: A Source for Forgotten Wound Healing Plants in Austrian Folk Medicine

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