Same-day initiation of oral pre-exposure prophylaxis among gay, bisexual, and other cisgender men who have sex with men and transgender women in Brazil, Mexico, and Peru (ImPrEP): a prospective, single-arm, open-label, multicentre implementation study

Veloso, Valdiléa G.; Cáceres, Carlos; Hoagland, Brenda; Moreira, Ronaldo I.; Vega-Ramírez, Hamid; Konda, Kelika A.; Leite, Iuri Costa; Bautista‐Arredondo, Sergio; Lacerda, Marcus Vinícius de; Madruga, José Valdez; Farias, Alessandro; Lima, Josué N; Zonta, R.; Lauria, Lilian; Tamayo, Cesar Vidal Osco; Flores, Hector Javier Salvatierra; Cruz, Yovanna Margot Cabrera Santa; Aguayo, Ricardo Martín Moreno; Cunha, Marcelo; Moreira, Júlio; Makkeda, Alessandra Ramos; Díaz, Steven; Guanira, Juan V.; Vermandere, Heleen; Benedetti, Marcos; Ingold, Heather; Pimenta, Cristina; Torres, Thiago Silva; Grinsztejn, Beatriz

doi:10.1016/s2352-3018(22)00331-9

Cited by 42 publications

(28 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…15 The cabotegravir long-acting dosage is considered the main advantage of this PrEP modality, 35 while effectiveness of oral PrEP depends on adherence to medication, a critical factor in certain groups, such as young MSM, which are less likely to adhere to daily PrEP. 23 , 36 – 38 In descriptive choice experiment (DCE) studies conducted among sexual and gender minorities in Brazil and Peru during 2020–2021, long-acting presentations and frequency of taking PrEP were important attributes in choosing PrEP modality. 20 , 21 , 39 Our findings provide additional information about preferences for alternative modalities to oral PrEP such as injectable PrEP among MSM in Latin America.…”

Section: Discussionmentioning

confidence: 99%

“… 2 , 28 However, results from the ImPrEP study showed that adherence to daily oral PrEP and long-term engagement to PrEP service were lower among MSM of younger age (<30 years) and lower education. 23 Information on efficacy of injectable PrEP should be available to all MSM to increase knowledge and interest for this PrEP modality, especially among those who would benefit the most, such as young MSM and those with intersecting social vulnerabilities.…”

Section: Discussionmentioning

confidence: 99%

“…The Implementation PrEP Project (ImPrEP), the first and largest transnational project in Latin America, provided evidence on feasibility, acceptability, and cost-effectiveness of daily oral PrEP among MSM and transgender women in Brazil, Mexico, and Peru. 18 – 23 Results from ImPrEP have been considered for decision making to incorporate oral PrEP as part of combination HIV prevention in Mexico 24 and to provide information for the maintenance and surveillance of PrEP policy in Brazil, where PrEP has been provided through the public health system (Sistema Único de Saúde [SUS]) since December 2017 with no direct cost to PrEP users. 25 Results from the ImPrEP demonstration study have shown that same-day oral PrEP provision was feasible for MSM and transgender women in Brazil, Mexico, and Peru.23 However, HIV incidence during the study was higher among non-white and younger (18–24 years) individuals and those non-adherent to daily oral PrEP.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preferences for PrEP modalities among gay, bisexual, and other men who have sex with men from Brazil, Mexico, and Peru: a cross-sectional study

Torres

Nascimento

Coelho

et al. 2023

Therapeutic Advances in Infection

Self Cite

View full text Add to dashboard Cite

Background: Pre-exposure prophylaxis (PrEP) scale-up is urgent to reduce new HIV cases among gay, bisexual, and other men who have sex with men (MSM) in Latin America. Different PrEP modalities may increase PrEP uptake and adherence, especially among young MSM. Objectives: To assess preferences for PrEP modalities among MSM from Brazil, Mexico, and Peru. Design: Cross-sectional web-based study (March–May 2018) targeting MSM through advertisements on Grindr, Hornet, and Facebook. We included MSM aged ⩾ 18 years and who reported HIV-negative status. Methods: We assessed preferences for PrEP modalities with the following question: ‘Considering that all following PrEP modalities were available, which one would you prefer considering a scale from 1 to 3 (1 = most preferred): daily oral PrEP, event-driven PrEP (ED-PrEP), and long-acting injectable PrEP’. We assessed factors associated with each most preferred PrEP modality per country using multivariable logistic regression models. Results: A total of 19,457 MSM completed the questionnaire (Brazil: 58%; Mexico: 31%; Peru: 11%); median age was 28 years [interquartile range (IQR): 24–34]. Overall, injectable PrEP was the most preferred modality [42%; 95% confidence interval (CI): 41–43], followed by daily PrEP (35%; 95% CI: 34–35), and ED-PrEP (23%; 95% CI: 23–24). In multivariable models, preferring injectable PrEP was associated with PrEP awareness in all three countries, while PrEP eligibility only in Brazil. Preferring daily PrEP was associated with younger age and lower income in Brazil and Mexico, and lower education only in Brazil. The odds of preferring ED-PrEP were lower among MSM aware and eligible for PrEP in Brazil and Mexico. Conclusions: Long-acting injectable PrEP was the preferred PrEP modality among MSM in Brazil, Mexico, and Peru, especially those aware and eligible for PrEP. Public health interventions to increase PrEP modalities literacy and availability in Latin America are urgent especially among MSM of young age, lower income, and lower education.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preferences for PrEP modalities among gay, bisexual, and other men who have sex with men from Brazil, Mexico, and Peru: a cross-sectional study

Torres

Nascimento

Coelho

et al. 2023

Therapeutic Advances in Infection

Self Cite

View full text Add to dashboard Cite

show abstract

“…PrEP was dispensed at the first visit (there was no screening visit) and participants were followed at weeks 4, 12 and every 12 weeks thereafter (quarterly). 23 PrEP SUS (Brazilian national PrEP program) was initiated at INI in 2017, users were provided same-day PrEP and followed at weeks 4, and every 12 weeks thereafter. 24…”

Section: Methodsmentioning

confidence: 99%

“… 21 In ImPrEP and PrEP SUS syphilis diagnosis at PrEP initiation was defined according to the reverse algorithm that used a treponemal test as the first test TPHA (Hemagglutination for Syphilis), followed by a non-treponemal test VDRL or RPR in the positive results. 23 …”

Section: Methodsmentioning

confidence: 99%

Travestis, transgender women and young MSM are at high risk for PrEP early loss to follow-up in Rio de Janeiro, Brazil

Guevara

Coelho

Veloso

et al. 2023

The Brazilian Journal of Infectious Diseases

View full text Add to dashboard Cite

Knowledge of HIV transmission, prevention strategies and U = U among adult sexual and gender minorities in Brazil

Silva,

Ferreira,

Coelho

et al. 2024

J Int AIDS Soc.

Self Cite

View full text Add to dashboard Cite

IntroductionAlthough strong scientific evidence of the efficacy and effectiveness of treatment‐as‐prevention (TasP) is available, full endorsement of the “Undetectable = Untransmittable” (U = U) and “zero‐risk” messages could be improved. Increasing knowledge about HIV transmission, prevention and treatment is a critical component of care efforts. The study assessed knowledge of HIV transmission and prevention strategies, and the perceived accuracy of the slogan U = U among sexual and gender minorities (SGM) in Brazil.MethodsCross‐sectional web‐based survey targeting adult SGM living in Brazil (2021−2022) recruited on social media and dating apps. We used the 12‐item HIV Knowledge Assessment (HIV‐KA) questionnaire to assess HIV knowledge, three items of which address pre‐exposure prophylaxis (PrEP), post‐exposure prophylaxis and TasP. Perceived accuracy of the U = U slogan was assessed with the question: “With regards to HIV‐positive individuals transmitting HIV through sexual contact, how accurate do you believe the slogan U = U is?”. We a priori grouped the study population into three mutually exclusive groups: people living with HIV (PLHIV), HIV negative and HIV unknown. We used logistic regression models to assess factors associated with high HIV knowledge and perception of the U = U as completely accurate.ResultsOf 50,222 individuals accessing the questionnaire, 23,981 were included: 5071 (21.0%) PLHIV, 17,257 (71.5%) HIV negative and 1653 (6.9%) HIV unknown. The proportion of participants with high knowledge was significantly higher for PLHIV and HIV negative (48.1% and 45.5%, respectively) compared to 26.1% of HIV unknown. More PLHIV perceived U = U as completely accurate (80.4%), compared to 60.0% of HIV negative and 42.9% of HIV unknown. HIV knowledge correlates with perceived accuracy of the U = U slogan across all groups. Higher HIV knowledge was associated with higher income and education regardless of HIV status. Among HIV‐negative participants, PrEP awareness and use were associated with higher knowledge and accurate perception of the U = U slogan.ConclusionsOur findings show that HIV knowledge and perceived accuracy of U = U are strongly correlated, that knowledge differs according to HIV status, and that poor socio‐economic is linked to poor knowledge among SGM from Brazil. Educational strategies regarding TasP, U = U and zero risk targeting socio‐economically vulnerable populations are urgent in Brazil.

show abstract

Same-day initiation of oral pre-exposure prophylaxis among gay, bisexual, and other cisgender men who have sex with men and transgender women in Brazil, Mexico, and Peru (ImPrEP): a prospective, single-arm, open-label, multicentre implementation study

Cited by 42 publications

References 31 publications

Preferences for PrEP modalities among gay, bisexual, and other men who have sex with men from Brazil, Mexico, and Peru: a cross-sectional study

Preferences for PrEP modalities among gay, bisexual, and other men who have sex with men from Brazil, Mexico, and Peru: a cross-sectional study

Travestis, transgender women and young MSM are at high risk for PrEP early loss to follow-up in Rio de Janeiro, Brazil

Knowledge of HIV transmission, prevention strategies and U = U among adult sexual and gender minorities in Brazil

Contact Info

Product

Resources

About