Sandblasted/Acid-Etched Titanium Surface Modified with Calcium Phytate Enhances Bone Regeneration in a High-Glucose Microenvironment by Regulating Reactive Oxygen Species and Cell Senescence

Dong, Shuang; Zhao, Tong; Wu, Wen‐Hong; Zhang, Zhe-Wei; Wu, Jin; Cai, Kunzhan; Li, Guoqing; Lv, Jiaxin; Zhou, Heyang; Tang, Chunbo

doi:10.1021/acsbiomaterials.3c00385

Cited by 13 publications

(5 citation statements)

References 52 publications

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“…According to Dong et al [43], osteointegration can be improved by modifying the implant surface. In the study, a titanium surface was enhanced with a mixture of phytic acid and calcium hydroxide.…”

Section: Discussionmentioning

confidence: 99%

Tetracalcium Phosphate Biocement Hardened with a Mixture of Phytic Acid–Phytase in the Healing Process of Osteochondral Defects in Sheep

Varga,

Kresakova,

Danko

et al. 2023

IJMS

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Hyaline articular cartilage has unique physiological, biological, and biomechanical properties with very limited self-healing ability, which makes the process of cartilage regeneration extremely difficult. Therefore, research is currently focused on finding new and potentially better treatment options. The main objective of this in vivo study was to evaluate a novel biocement CX consisting of tetracalcium phosphate–monetit biocement hardened with a phytic acid–phytase mixture for the regeneration of osteochondral defects in sheep. The results were compared with tetracalcium phosphate–monetit biocement with classic fast-setting cement systems and untreated defects. After 6 months, the animals were sacrificed, and the samples were evaluated using macroscopic and histologic methods as well as X-ray, CT, and MR-imaging techniques. In contrast to the formation of fibrous or fibrocartilaginous tissue on the untreated side, treatment with biocements resulted in the formation of tissue with a dominant hyaline cartilage structure, although fine fibres were present (p < 0.001). There were no signs of pathomorphological changes or inflammation. Continuous formation of subchondral bone and hyaline cartilage layers was present even though residual biocement was observed in the trabecular bone. We consider biocement CX to be highly biocompatible and suitable for the treatment of osteochondral defects.

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Section: Discussionmentioning

confidence: 99%

Tetracalcium Phosphate Biocement Hardened with a Mixture of Phytic Acid–Phytase in the Healing Process of Osteochondral Defects in Sheep

Varga,

Kresakova,

Danko

et al. 2023

IJMS

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“…Clinical investigations revealed a higher incidence of early implant failure compared with late failure in diabetic patients and increased the risk of peri-implantitis, a crucial factor in the overall success of dental implants with 5% of patients experiencing implant failure due to implantitis (Chrcanovic et al 2014). While direct evidence establishing a link between poor metabolic control, hyperglycemia, and implant failure remains limited, the strategies using surface modifications to improve implant success have been a focus; for example, sandblasted/acid-etched titanium surface modified with calcium phytate is a candidate for improving implant osseointegration (Dong et al 2023). Even though it is unusual to treat patients with poor hyperglycemic control, insights from preclinical studies can shed light to more options when considering implant therapy for diabetic patients.…”

Section: Animal Models Of T2dmmentioning

confidence: 99%

Strategies for Improving Impaired Osseointegration in Compromised Animal Models

Deng,

Van Duyn,

Cohen

et al. 2024

J Dent Res

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Implant osseointegration is reduced in patients with systemic conditions that compromise bone quality, such as osteoporosis, disuse syndrome, and type 2 diabetes. Studies using rodent models designed to mimic these compromised conditions demonstrated reduced bone-to-implant contact (BIC) or a decline in bone mineral density. These adverse effects are a consequence of disrupted intercellular communication. A variety of approaches have been developed to compensate for the altered microenvironment inherent in compromised conditions, including the use of biologics and implant surface modification. Chemical and physical modification of surface properties at the microscale, mesoscale, and nanoscale levels to closely resemble the surface topography of osteoclast resorption pits found in bone has proven to be a highly effective strategy for improving implant osseointegration. The addition of hydrophilicity to the surface further enhances osteoblast response at the bone-implant interface. These surface modifications, applied either alone or in combination, improve osseointegration by increasing proliferation and osteoblastic differentiation of osteoprogenitor cells and enhancing angiogenesis while modulating osteoclast activity to achieve net new bone formation, although the specific effects vary with surface treatment. In addition to direct effects on surface-attached cells, the communication between bone marrow stromal cells and immunomodulatory cells is sensitive to these surface properties. This article reports on the advances in titanium surface modifications, alone and in combination with novel therapeutics in animal models of human disease affecting bone quality. It offers clinically translatable perspectives for clinicians to consider when using different surface modification strategies to improve long-term implant performance in compromised patients. This review supports the use of surface modifications, bioactive coatings, and localized therapeutics as pragmatic approaches to improve BIC and enhance osteogenic activity from both structural and molecular standpoints.

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“…During the processes of bone healing after trauma (such as TES), HBMSCs are recruited from bone marrow to the damaged area and differentiate into osteoblasts, leading to the secretion, synthesis, and mineralization of bone matrix . It has been demonstrated that accumulated ROS disrupted the osteogenic differentiation of HBMSCs, resulting in compromised bone metabolism and impaired bone regeneration . In addition, bone is composed of highly vascularized tissue, and these blood vessels play important roles in bone remodeling .…”

Section: Introductionmentioning

confidence: 99%

“…21 It has been demonstrated that accumulated ROS disrupted the osteogenic differentiation of HBMSCs, resulting in compromised bone metabolism and impaired bone regeneration. 22 In addition, bone is composed of highly vascularized tissue, and these blood vessels play important roles in bone remodeling. 23 HUVECs compose the blood vessels and secrete several angiogenesis factors.…”

Section: ■ Introductionmentioning

confidence: 99%

An Injectable Black Phosphorus Hydrogel for Rapid Tooth Extraction Socket Healing

Guo,

Li,

Chen

et al. 2024

ACS Appl. Mater. Interfaces

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The excess production of reactive oxygen species (ROS) will delay tooth extraction socket (TES) healing. In this study, we developed an injectable thermosensitive hydrogel (NBP@BP@CS) used to treat TES healing. The hydrogel formulation incorporated black phosphorus (BP) nanoflakes, recognized for their accelerated alveolar bone regeneration and ROS-scavenging properties, and dl-3-n-butylphthalide (NBP), a vasodilator aimed at enhancing angiogenesis. In vivo investigations strongly demonstrated that NBP@BP@CS improved TES healing due to antioxidation and promotion of alveolar bone regeneration by BP nanoflakes. The sustained release of NBP from the hydrogel promoted neovascularization and vascular remodeling. Our results demonstrated that the designed thermosensitive hydrogel provided great opportunity not only for ROS elimination but also for the promotion of osteogenesis and angiogenesis, reflecting the "three birds with one stone" concept, and has tremendous potential for rapid TES healing.

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Sandblasted/Acid-Etched Titanium Surface Modified with Calcium Phytate Enhances Bone Regeneration in a High-Glucose Microenvironment by Regulating Reactive Oxygen Species and Cell Senescence

Cited by 13 publications

References 52 publications

Tetracalcium Phosphate Biocement Hardened with a Mixture of Phytic Acid–Phytase in the Healing Process of Osteochondral Defects in Sheep

Tetracalcium Phosphate Biocement Hardened with a Mixture of Phytic Acid–Phytase in the Healing Process of Osteochondral Defects in Sheep

Strategies for Improving Impaired Osseointegration in Compromised Animal Models

An Injectable Black Phosphorus Hydrogel for Rapid Tooth Extraction Socket Healing

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