Sandwich theory: Bioactivity-based explanation for posterior capsule opacification

Linnola, Reijo J.

doi:10.1016/s0886-3350(97)80026-0

Cited by 125 publications

(64 citation statements)

References 13 publications

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“…Reports suggest that the two primary reasons for the marked improvement are the ''sharp rectangular edge design'' and possibly ''increased adhesiveness'' to the lens capsule (Linnola 1997;Nagata et al 1998;Nishi et al 2000). Indeed, because of the apparent mechanical advantages of the AcrySof lens, other mechanically motivated devices have been tried as well.…”

Section: Introductionmentioning

confidence: 99%

Multiaxial mechanical behavior of the porcine anterior lens capsule

Heistand

Pedrigi

Delange

et al. 2005

Biomech Model Mechanobiol

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The biomechanics of the lens capsule of the eye is important both in physiologic processes such as accommodation and clinical treatments such as cataract surgery. Although the lens capsule experiences multiaxial stresses in vivo, there have been no measurements of its multiaxial properties or possible regional heterogeneities. Rather all prior mechanical data have come from 1-D pressure-volume or uniaxial force-length tests. Here, we report a new experimental approach to study in situ the regional, multiaxial mechanical behavior of the lens capsule. Moreover, we report multiaxial data suggesting that the porcine anterior lens capsule exhibits a typical nonlinear pseudo-elastic behavior over finite strains, that the in situ state is pre-stressed multi-axially, and that the meridional and circumferential directions are principal directions of strain, which is nearly equi-biaxial at the pole but less so towards the equator. Such data are fundamental to much needed constitutive formulations.

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Section: Introductionmentioning

confidence: 99%

Multiaxial mechanical behavior of the porcine anterior lens capsule

Heistand

Pedrigi

Delange

et al. 2005

Biomech Model Mechanobiol

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“…The scientific studies in the field of preventative and treatment measures to combat PCO include patient-related factors [1,3,7,9,11,19], to the surgery [15,16,18] and to intraocular lens design and structure [4,10,12,13,21]. These studies are reliant on accurate analysis to quantify the PCO in question.…”

Section: Introductionmentioning

confidence: 99%

Posterior capsule morphology determinants of visual function

Aslam

Aspinall

Dhillon

2003

Graefe's Arch Clin Exp Ophthalmol

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“…Our results demonstrate that the adhesiveness of acrylic materials measured with a tackiness tester correlates with the cell-free area on the collagen membrane, as well as with PCO in rabbit eyes: the more adhesive the hydrophobic acrylic IOL is, the less PCO induced in rabbit eyes. Linnola [28] and Linnola et al [29] presented a bioactivity-based explanation for PCO formation. According to his sandwich theory, the degree of IOL bioactivity could explain the difference in PCO with different IOL materials [28] .…”

Section: Discussionmentioning

confidence: 99%

“…Linnola [28] and Linnola et al [29] presented a bioactivity-based explanation for PCO formation. According to his sandwich theory, the degree of IOL bioactivity could explain the difference in PCO with different IOL materials [28] . Moreover, the stronger binding of fibronectin and laminin to acrylate IOLs could be an explanation for the better adhesion of the acrylate IOL to the anterior and posterior capsules and thus for the lower rate of PCO [17] .…”

Section: Discussionmentioning

confidence: 99%

The Relationship between the Adhesion Characteristics of Acrylic Intraocular Lens Materials and Posterior Capsule Opacification

Katayama¹,

Kobayakawa²,

Yanagawa³

et al. 2007

Ophthalmic Res

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Purpose: To investigate the relationship between the adhesion characteristics of similarly designed hydrophobic acrylic intraocular lenses (IOLs) and posterior capsule opacification (PCO). Methods: Three similarly shaped hydrophobic acrylic IOLs with a sharp-edged optic were used. Adhesive force of IOLs was measured with a tackiness tester. Human lens epithelial cells (LECs) were grown on each IOL for 48 h. LECs were then stained with crystal violet, which served as an index of the amount of cells attached to IOLs. Cellular migration and proliferation assays were performed using chamber inserts containing a collagen membrane. After 96 h of incubation, the collagen membranes were stained with hematoxylin and eosin for analysis. Three similarly shaped IOLs were implanted in rabbits. The eyes were enucleated 3 weeks later and analyzed for PCO area. Results: Hydrophobic acrylic IOLs were classified into three groups: A (less adhesive), B (moderately) and C (highly). The migration area of LECs on the collagen membrane was 5.65 ± 4.5% in group A, 2.83 ± 2.1% in group B, and 1.41 ± 1.5% in group C, with a significant difference between groups A and C (p < 0.05). The mean percentage area of PCO in the rabbit eye was 19.4 ± 16.7% in group A, 17.5 ± 8.5% in group B, and 5.5 ± 3.8% in group C, with a significant difference between groups A and C (p < 0.05). Conclusion: Adhesive force of hydrophobic acrylic IOLs may play an important role in preventing PCO. Among the similarly shaped hydrophobic acrylic IOLs, IOLs of highly adhesive material inhibited LEC migration and PCO more than IOLs of less adhesive material.

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Sandwich theory: Bioactivity-based explanation for posterior capsule opacification

Abstract: The degree of IOL bioactivity could explain the difference in PCO and the neodymium:YAG rates with different IOL materials. In theory, a bioactive IOL would prevent PCO better than poly(methyl methacrylate) and silicone IOLs, which have good biocompatibility but are bioinert.

Cited by 125 publications

References 13 publications

Multiaxial mechanical behavior of the porcine anterior lens capsule

Multiaxial mechanical behavior of the porcine anterior lens capsule

Posterior capsule morphology determinants of visual function

The Relationship between the Adhesion Characteristics of Acrylic Intraocular Lens Materials and Posterior Capsule Opacification

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