Sang-Yod rice bran hydrolysates alleviate hypertension, endothelial dysfunction, vascular remodeling, and oxidative stress in nitric oxide deficient hypertensive rats

Kukongviriyapan, Upa; Jan-on, Gulladawan; Tubsakul, Akarachai; Sangartit, Weerapon; Pakdeechote, Poungrat; Kukongviriyapan, Veerapol; Senaphan, Ketmanee; Thongraung, Chakree

doi:10.4103/2221-1691.300727

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Secondly, we used the CIE L*a*b* color space system. The lightness (L*), red/green is (a*), and yellow/blue is (b*) values of color were measured by colorimeter (Minolta CR 400, Germany) [12,13]. In addition, moisture and water activity (aw) were measured using the EZ-200, Japan, according to the AOAC 2000.…”

Section: Experimental Design and Sample Preparationmentioning

confidence: 99%

“…Pigmented rice grains contain nutraceuticals like total phenolic acids, vitamins, and antioxidative substances in addition to carbohydrates and proteins. These nutraceuticals fight against severe diseases like cancer, hypertension, and inflammation (Chen et al, 2012;Hartati et al, 2017;Jan-On et al, 2021). Black rice is high in proteins, fat, and fibers, while red rice varieties are rich sources of minerals consisting of iron and zinc.…”

Section: Introductionmentioning

confidence: 99%

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Identification of Nutraceuticals and Antioxidant Activity in Low-Cost Broken Rice Varieties

Srisuk¹

2022

Journal of Pharmaceutical Negative Results

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Rice grains are the main crops consumed by more than half of the world’s population. White rice contains carbohydrates, while pigmented rice varieties are more nutritious, with bioactive compounds that can potentially prevent pro-inflammatory diseases like diabetes and hypertension. Broken rice is produced in large quantities as a cheap by-product of milling; however, its nutraceutical contents have not been identified. Therefore, the research aimed to examine four low-cost broken rice varieties’ color values and bioactive compound contents. Kiaw-Ngu glutinous rice (white rice) and brown Jasmine rice 105 were used as control, while Riceberry rice and Sangyod rice represented pigmented rice varieties. Color values were analyzed using the RHS color chart and the CIE L*a*b* color space system. Antioxidant activity was measured using DPPH assay, while total phenolic compounds were determined by the Folin–Ciocalteu’s method. Water-soluble vitamins (B1, 2, and 6) and fat-soluble vitamins (E and -carotene) were determined using HPLC. The analyzed results illustrated that the Riceberry rice had the most potent antioxidant activity (83.45%), followed by Sangyod rice, brown Jasmine rice 105, and Kiaw-Ngu glutinous rice, respectively. Similarly, Riceberry rice contained the highest level of total phenolic acid (236.98 mg gallic acid equivalent (GAE)/g). Vitamin B1 level is highest in the Riceberry rice, while vitamin B2 level was comparably highest in the Riceberry rice and Sangyod rice. However, vitamin B6 was not detectable in any strains of the rice varieties. The Riceberry rice and Sangyod rice also contained vitamin E and β-carotene. In conclusion, pigmented rice grains possess antioxidant activity, phenolic acids, vitamins B1, B2, E, and β-carotene.

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Section: Experimental Design and Sample Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification of Nutraceuticals and Antioxidant Activity in Low-Cost Broken Rice Varieties

Srisuk¹

2022

Journal of Pharmaceutical Negative Results

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Astaxanthin attenuates cardiovascular dysfunction associated with deoxycorticosterone acetate-salt-induced hypertension in rats

Khodir

Sweed

Gadallah

et al. 2022

Clinical and Experimental Hypertension

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House cricket protein hydrolysates alleviate hypertension, vascular dysfunction, and oxidative stress in nitric oxide-deficient hypertensive rats

Sangartit,

Suwannachot,

Thawornchinsombut

et al. 2024

Vet World

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Background and Aim: Edible insects with high protein content and bioactive peptides with health promotion against chronic disease. Deficiency of nitric oxide (NO) contributes to hypertension, a leading cause of cardiovascular diseases and death worldwide. This study assessed the antihypertensive effects of house cricket protein hydrolysates (HCPH) in NO-deficient hypertensive rats. Materials and Methods: Male Sprague-Dawley rats (n = 12/group) were hypertensive after the administration of Nω-nitro-L-arginine methyl ester (L-NAME) at a dose of 50 mg/kg body weight (BW)/day in drinking water for 7 weeks. The animals were then treated with HCPH (250 or 500 mg/kg BW/day) or lisinopril (Lis) (1 mg/kg BW/day) for the last 4 weeks of L-NAME administration. Blood pressure (BP), vascular function, and structural changes, endothelial NO synthase (eNOS), and p47phox nicotinamide adenine dinucleotide phosphate (NADPH) oxidase protein expression in aortic tissues, plasma nitrate/nitrite, plasma angiotensin-converting enzyme (ACE) activity, and oxidative stress markers in blood and tissues were evaluated. Results: Induction of hypertension resulted in significantly elevated BP, decreased plasma nitrate/nitrite concentration, abolished vascular function, and increased vascular wall thickness. Overproduction of carotid and mesenteric superoxide, increased plasma, heart, and kidney malondialdehyde, and protein carbonyl levels, and increased plasma ACE activity were observed. Down-expression of eNOS with overexpression of p47phox NADPH oxidase subunit was also found in L-NAME hypertensive rats. Oral treatment with HCPH, particularly at a dose of 500 mg/kg BW/day, significantly alleviated these alterations in a manner comparable to that of Lis. Conclusion: HCPH improved vascular function and exerted antihypertensive effects, mainly due to the improvement of NO bioavailability, reduction of oxidative stress, and inhibition of ACE. Keywords: angiotensin-converting enzyme activity, house cricket protein hydrolysates, hypertension, nitric oxide deficiency, oxidative stress, vascular dysfunction.

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Sang-Yod rice bran hydrolysates alleviate hypertension, endothelial dysfunction, vascular remodeling, and oxidative stress in nitric oxide deficient hypertensive rats

Cited by 4 publications

References 35 publications

Identification of Nutraceuticals and Antioxidant Activity in Low-Cost Broken Rice Varieties

Identification of Nutraceuticals and Antioxidant Activity in Low-Cost Broken Rice Varieties

Astaxanthin attenuates cardiovascular dysfunction associated with deoxycorticosterone acetate-salt-induced hypertension in rats

House cricket protein hydrolysates alleviate hypertension, vascular dysfunction, and oxidative stress in nitric oxide-deficient hypertensive rats

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