Sanguinarine does not influence availability or metabolism of tryptophan in pigs

Blank, Ralf; Müller-Siegwardt, B.; Wolffram, Siegfried

doi:10.1016/j.livsci.2010.06.086

Cited by 12 publications

(14 citation statements)

References 7 publications

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“…This has stimulated interest in phytogenic feed supplements that reduce gastrointestinal pathogen levels, enabling animals to redistribute immune defense resources to growth [ 235 ]. Thus, Sangrovit, derived from the aerial parts of M. cordata or the rhizomes of S. canadensis , was developed as a natural feed additive [ 236 , 237 ]. The sanguinarine content of Sangrovit was standardized to 1.5% w / w .…”

Section: Current Uses Of S Canadensismentioning

confidence: 99%

Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses

Croaker

King

Pyne

et al. 2016

IJMS

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Sanguinaria canadensis, also known as bloodroot, is a traditional medicine used by Native Americans to treat a diverse range of clinical conditions. The plants rhizome contains several alkaloids that individually target multiple molecular processes. These bioactive compounds, mechanistically correlate with the plant’s history of ethnobotanical use. Despite their identification over 50 years ago, the alkaloids of S. canadensis have not been developed into successful therapeutic agents. Instead, they have been associated with clinical toxicities ranging from mouthwash induced leukoplakia to cancer salve necrosis and treatment failure. This review explores the historical use of S. canadensis, the molecular actions of the benzophenanthridine and protopin alkaloids it contains, and explores natural alkaloid variation as a possible rationale for the inconsistent efficacy and toxicities encountered by S. canadensis therapies. Current veterinary and medicinal uses of the plant are studied with an assessment of obstacles to the pharmaceutical development of S. canadensis alkaloid based therapeutics.

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Section: Current Uses Of S Canadensismentioning

confidence: 99%

Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses

Croaker

King

Pyne

et al. 2016

IJMS

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“…on feed intake in farming animals. Some studies claimed that sanguinarine additives had no impact on feed consumption [28, 37]. Conversely, other researchers [25, 26] subscribed to the belief that sanguinarine could influence feed intake by regulating the pathway for the synthesis of serotonin by using tryptophan.…”

Section: The Impact Of Isoquinoline Alkaloids Derived From Extracmentioning

confidence: 99%

Analysis of the Impact of Isoquinoline Alkaloids, Derived fromMacleaya cordataExtract, on the Development and Innate Immune Response in Swine and Poultry

Martínez

Guan

et al. 2016

BioMed Research International

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Medicinal extract has been chronicled extensively in traditional Chinese medicine. Isoquinoline alkaloids, extract of Macleaya cordata (Willd.) R. Br., have been used as feed additive in both swine and poultry. Dietary supplementation with isoquinoline alkaloids increases feed intake and weight gain. In addition, recent researches have demonstrated that isoquinoline alkaloids can regulate metabolic processes, innate immune system, and digestive functioning in animals. This review summarizes the latest scientific researches on isoquinoline alkaloids which are extracted from Macleaya cordata (Willd.) R. Br. This review specifically focuses on its role as a feed supplement and its associated impact on growth performance and innate immune system, as well as its capacity to act as a substitute for oral antibiotics.

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“…The antimicrobial activity of selected plant extracts, such as Chinese medicinal herbs or feed additive derived from Sanguinaria canadensis, essential oil components from herbs and spices or tannin-rich preparations, may offer a strategy to reduce skatole formation [ 41 , 80 , 81 , 82 ]. The addition of tannin-rich extracts of several plants inhibits either microbial activity directly or by reducing the availability of proteins for bacterial metabolism.…”

Section: Effects Of Diet and Feed Additives On Skatole Formation mentioning

confidence: 99%

Nutritional Influences on Skatole Formation and Skatole Metabolism in the Pig

Wesoly

Weiler

2012

Animals

103

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SummarySkatole is a tryptophan metabolite with fecal odor. Skatole and the testicular steroid androstenone are regarded as the main compounds leading to ‘boar taint,’ a sex-specific odor from pork taken from entire males, as elevated concentrations of both substances may be found in adipose boars tissue. High skatole concentrations in adipose tissue are the result of a complex process, which includes microbial formation in the colon, absorption, metabolism and accretion in fat. Several of these steps leading to high skatole concentrations are influenced by feed components and additives. The present paper discusses the mechanisms by which effective feeding strategies and feed additives exert their influence in the prevention of high skatole concentrations in adipose pig tissue.

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Sanguinarine does not influence availability or metabolism of tryptophan in pigs

Cited by 12 publications

References 7 publications

Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses

Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses

Analysis of the Impact of Isoquinoline Alkaloids, Derived fromMacleaya cordataExtract, on the Development and Innate Immune Response in Swine and Poultry

Nutritional Influences on Skatole Formation and Skatole Metabolism in the Pig

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