Sanguisorba officinalis extract, ziyuglycoside I, and II exhibit antiviral effects against hepatitis B virus

Jang, Eungyeong; Kim, Soyoung; Lee, Na Rae; Kim, Hayeon; Chae, Soo-In; Han, Chang Woo; Kim, Young‐Chul; Lee, Kyung Tae; Kim, Bum Joon; Lee, Jang Hoon

doi:10.1016/j.eujim.2018.05.009

Cited by 8 publications

(3 citation statements)

References 36 publications

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“…In addition to being a wild edible plants, S. officinalis is also widely used for treating several diseases. Sanguisorbae Radix , the dry root of S. officinalis or S. longifolia Bertol , has been traditionally used for cooling the blood, clearing heat, healing wounds and alleviating snake bites ( Hachiya et al, 2001 ; Karkanis et al, 2014 ; Liu et al, 2014 ; Jang et al, 2018b ). In Korea, the whole plant of S. officinalis is used slightly differently compared to its roots; while the whole plant is commonly applied for the treatment of diseases in women and bloody stool hemorrhoid pus, the root is mostly used for treating inflammation and for skin regeneration ( Kim and Song, 2011 ).…”

Section: Traditional Uses Of Genus Sanguisorba Plantsmentioning

confidence: 99%

A Comprehensive Review of Genus Sanguisorba: Traditional Uses, Chemical Constituents and Medical Applications

Zhou

Chen

et al. 2021

Front. Pharmacol.

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Genus Sanguisorba (family: Rosaceae) comprises nearly 148 species, distributed widely across the temperate and subtropical regions of the Northern Hemisphere. Sanguisorba officinalis L. (S. officinalis) has been used as a hemostatic and scald treating medicine in China for a long time. Numerous studies have demonstrated that plant extracts or monomers from S. officinalis exhibit several pharmacological effects, such as anti-cancer, anti-virus, anti-inflammation, anti-bacteria, neuroprotective and hepatoprotective effects. The other species of genus Sanguisorba are also being studied by researchers worldwide. Sanguisorba minor Scop. (S. minor), as an edible wild plant, is a common ingredient of the Mediterranean diet, and its young shoots and leaves are often mixed with traditional vegetables and consumed as salad. Reports on genus Sanguisorba available in the current literature were collected from Google Scholar, Web of Science, Springer, and PubMed. The Plant List (http://www.theplantlist.org./tpl1.1/search?q=Sanguisorba), International Plant Name Index (https://www.ipni.org/?q=Sanguisorba) and Kew Botanical Garden (http://powo.science.kew.org/) were used for obtaining the scientific names and information on the subspecies and cultivars. In recent years, several in vivo and in vitro experiments have been conducted to reveal the active components and effective monomers of S. officinalis and S. minor. To date, more than 270 compounds have been isolated and identified so far from the species belonging to genus Sanguisorba. Numerous reports on the chemical constituents, pharmacologic effects, and toxicity of genus Sanguisorba are available in the literature. This review provides a comprehensive understanding of the current traditional applications of plants, which are supported by a large number of scientific experiments. Owing to these promising properties, this species is used in the treatment of various diseases, including influenza virus infection, inflammation, Alzheimer’s disease, type 2 diabetes and leukopenia caused by bone marrow suppression. Moreover, the rich contents and biological effects of S. officinalis and S. minor facilitate these applications in dietary supplements and cosmetics. Therefore, the purpose of this review is to summarize the recent advances in the traditional uses, chemical constituents, pharmacological effects and clinical applications of genus Sanguisorba. The present comprehensive review may provide new insights for the future research on genus Sanguisorba.

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Section: Traditional Uses Of Genus Sanguisorba Plantsmentioning

confidence: 99%

A Comprehensive Review of Genus Sanguisorba: Traditional Uses, Chemical Constituents and Medical Applications

Zhou

Chen

et al. 2021

Front. Pharmacol.

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“…Moreover, various studies reported the bioactivities of SO roots, including anti-inflammatory, antioxidant, and anti-obesity activities [18][19][20]. Among the compounds derived from the roots of SO are triterpenoids and phenolic acids, such as gallic acid, catechin, ziyuglycoside I (ZG1), and ziyuglycoside II (ZG2) [21,22]. Specifically, ZG1 and ZG2, which exhibit anti-inflammatory and anticancer effects, were exclusively found in the roots of SO [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

“…Among the compounds derived from the roots of SO are triterpenoids and phenolic acids, such as gallic acid, catechin, ziyuglycoside I (ZG1), and ziyuglycoside II (ZG2) [21,22]. Specifically, ZG1 and ZG2, which exhibit anti-inflammatory and anticancer effects, were exclusively found in the roots of SO [22][23][24]. Despite the physiological activity of the SO root and its derived compounds, their effects on hepatic steatosis and fibrosis have not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

Sanguisorba officinalis L. Ameliorates Hepatic Steatosis and Fibrosis by Modulating Oxidative Stress, Fatty Acid Oxidation, and Gut Microbiota in CDAHFD-Induced Mice

Nam,

Kim,

Erdenebileg

et al. 2023

Nutrients

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Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver diseases and encompasses non-alcoholic steatosis, steatohepatitis, and fibrosis. Sanguisorba officinalis L. (SO) roots have traditionally been used for their antioxidant properties and have beneficial effects on metabolic disorders, including diabetes and obesity. However, its effects on hepatic steatosis and fibrosis remain unclear. In this study, we explored the effects of a 95% ethanolic SO extract (SOEE) on NAFLD and fibrosis in vivo and in vitro. The SOEE was orally administered to C57BL/6J mice fed a choline-deficient, L-amino-acid-defined, high-fat diet for 10 weeks. The SOEE inhibited hepatic steatosis by modulating hepatic malondialdehyde levels and the expression of oxidative stress-associated genes, regulating fatty-acid-oxidation-related genes, and inhibiting the expression of genes that are responsible for fibrosis. The SOEE suppressed the deposition of extracellular matrix hydroxyproline and mRNA expression of fibrosis-associated genes. The SOEE decreased the expression of fibrosis-related genes in vitro by inhibiting SMAD2/3 phosphorylation. Furthermore, the SOEE restored the gut microbial diversity and modulated specific bacterial genera associated with NAFLD and fibrosis. This study suggests that SOEE might be the potential candidate for inhibiting hepatic steatosis and fibrosis by modulating oxidative stress, fatty acid oxidation, and gut microbiota composition.

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An antiviral optimized extract from Sanguisorba officinalis L. roots using response surface methodology, and its efficacy in controlling viral hemorrhagic septicemia of olive flounder (Paralichthys olivaceus)

Lim,

Seo,

Jung

et al. 2023

Fish & Shellfish Immunology

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Sanguisorba officinalis extract, ziyuglycoside I, and II exhibit antiviral effects against hepatitis B virus

Cited by 8 publications

References 36 publications

A Comprehensive Review of Genus Sanguisorba: Traditional Uses, Chemical Constituents and Medical Applications

A Comprehensive Review of Genus Sanguisorba: Traditional Uses, Chemical Constituents and Medical Applications

Sanguisorba officinalis L. Ameliorates Hepatic Steatosis and Fibrosis by Modulating Oxidative Stress, Fatty Acid Oxidation, and Gut Microbiota in CDAHFD-Induced Mice

An antiviral optimized extract from Sanguisorba officinalis L. roots using response surface methodology, and its efficacy in controlling viral hemorrhagic septicemia of olive flounder (Paralichthys olivaceus)

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