Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages

Yasueda, Asuka; Kayama, Hisako; Murohashi, Michiko; Nishimura, Junichi; Wakame, Koji; Komatsu, Kenichi; Ogino, Takayuki; Miyoshi, Norikatsu; Takahashi, Hidekazu; Uemura, Mamoru; Matsuda, Chu; Kitagawa, Toru; Ito, Toshinori; Doki, Yuichiro; Eguchi, Hidetoshi; Shimizu, Shigeomi; Mizushima, Tsunekazu

doi:10.1038/s41598-020-65306-4

Cited by 25 publications

(19 citation statements)

References 60 publications

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Section: Pharmacological Effects Exhibited By Genus Sanguisorbamentioning

confidence: 99%

“…S. officinalis has been used for the treatment of inflammatory diseases, including the airway inflammation in bronchial asthma (Lee et al, 2010), contact dermatitis (Jo et al, 2015), specific dermatitis (Park et al, 2015;Yang et al, 2016a), nephritis (Zhao et al, 2019), colitis (Shao et al, 2017;Fang et al, 2018;Yasueda et al, 2020), etc., for a long time. Yu et al (2011) reported that the ethanol extract of S. officinalis plants could block the production of representative inflammatory mediators nitric oxide (NO) and prostaglandin E2 (PEG2) at the transcription level in an in vitro model of RAW264.7 cells stimulated by 1 μg/ml lipopolysaccharide (LPS).…”

Section: Anti-inflammatory Effectsmentioning

confidence: 99%

“…Seo et al further confirmed the anti-inflammatory effect of the water extract of S. officinalis (HSO) in an in vivo mouse model induced by LPS (3 mg/kg), demonstrating that the oral consumption of HSO (5 or 25 mg/kg•day) significantly reduced the levels of serum as well as intraperitoneal interleukin 1β (IL-1β) in a dose-dependent manner along with improving the survival rate (Seo et al, 2018). Moreover, S. officinalis at a dose of 1 mg/ml reportedly activated autophagic activity and significantly inhibited 2% dextran sodium sulfate (DSS)-induced colitis, without damaging the liver, heart, and kidneys in mice (Yasueda et al, 2020). The chemical components mainly responsible for the antiinflammatory activity exhibited by root parts are phenolic compounds and linear monoterpenes (Su et al, 2018a).…”

Section: Anti-inflammatory Effectsmentioning

confidence: 99%

“…The Plant List ( The Plant List, 2021 ), International Plant Name Index ( International Plant Name Index, 2021 ) and Kew Botanical Garden ( Kew Botanical Garden, 2021a ; Kew Botanical Garden, 2021b ) were used for obtaining the scientific names and information on the subspecies and cultivars. Studies have demonstrated that the crude extracts from plants belonging to genus Sanguisorba or the purified monomers isolated from the plants of this genus exhibit various pharmacological activities, including anti-inflammatory ( Su et al, 2018a ; Guo et al, 2019 ; Yasueda et al, 2020 ), anti-cancer ( Liu et al, 2016 ; Nam et al, 2017 ; Tan et al, 2019 ; Bai et al, 2020a ; Liao et al, 2020 ), anti-lipid peroxidation ( Zhang et al, 2012a ; Romojaro et al, 2013a ; Kim et al, 2018a ; Lenzi et al, 2019 ), anti-bacteria ( Su et al, 2019 ; Zhu et al, 2020a ), anti-diabetes ( Kuang et al, 2011 ; Son et al, 2015 ), hepatoprotective ( Stojiljković et al, 2019 ; Meng et al, 2020 ), and anti-obesity ( Jung et al, 2016 ; Im et al, 2017 ; Ji et al, 2018 ) properties, both in vitro and in vivo ( Figure1 ).…”

Section: Introductionmentioning

confidence: 99%

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A Comprehensive Review of Genus Sanguisorba: Traditional Uses, Chemical Constituents and Medical Applications

Zhou

Chen

et al. 2021

Front. Pharmacol.

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Genus Sanguisorba (family: Rosaceae) comprises nearly 148 species, distributed widely across the temperate and subtropical regions of the Northern Hemisphere. Sanguisorba officinalis L. (S. officinalis) has been used as a hemostatic and scald treating medicine in China for a long time. Numerous studies have demonstrated that plant extracts or monomers from S. officinalis exhibit several pharmacological effects, such as anti-cancer, anti-virus, anti-inflammation, anti-bacteria, neuroprotective and hepatoprotective effects. The other species of genus Sanguisorba are also being studied by researchers worldwide. Sanguisorba minor Scop. (S. minor), as an edible wild plant, is a common ingredient of the Mediterranean diet, and its young shoots and leaves are often mixed with traditional vegetables and consumed as salad. Reports on genus Sanguisorba available in the current literature were collected from Google Scholar, Web of Science, Springer, and PubMed. The Plant List (http://www.theplantlist.org./tpl1.1/search?q=Sanguisorba), International Plant Name Index (https://www.ipni.org/?q=Sanguisorba) and Kew Botanical Garden (http://powo.science.kew.org/) were used for obtaining the scientific names and information on the subspecies and cultivars. In recent years, several in vivo and in vitro experiments have been conducted to reveal the active components and effective monomers of S. officinalis and S. minor. To date, more than 270 compounds have been isolated and identified so far from the species belonging to genus Sanguisorba. Numerous reports on the chemical constituents, pharmacologic effects, and toxicity of genus Sanguisorba are available in the literature. This review provides a comprehensive understanding of the current traditional applications of plants, which are supported by a large number of scientific experiments. Owing to these promising properties, this species is used in the treatment of various diseases, including influenza virus infection, inflammation, Alzheimer’s disease, type 2 diabetes and leukopenia caused by bone marrow suppression. Moreover, the rich contents and biological effects of S. officinalis and S. minor facilitate these applications in dietary supplements and cosmetics. Therefore, the purpose of this review is to summarize the recent advances in the traditional uses, chemical constituents, pharmacological effects and clinical applications of genus Sanguisorba. The present comprehensive review may provide new insights for the future research on genus Sanguisorba.

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Section: Pharmacological Effects Exhibited By Genus Sanguisorbamentioning

confidence: 99%

Section: Anti-inflammatory Effectsmentioning

confidence: 99%

Section: Anti-inflammatory Effectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Comprehensive Review of Genus Sanguisorba: Traditional Uses, Chemical Constituents and Medical Applications

Zhou

Chen

et al. 2021

Front. Pharmacol.

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“…The roots of S. officinalis have been traditionally used to treat diarrhea, chronic intestinal inflammation, duodenal ulcers, and bleeding hemorrhoids [ 12 ]. The ingredient compounds of S. officinalis , such as ziyuglycosides I, ziyuglycosides II, sanguiin H-6, ellagic acid, and quercetin, have been reported for various pharmacological action, including antiallergic, anti-inflammatory, anti-obesity, and anticancer [ 13 , 15 , 16 ]. However, no previous paper reported the effect of S. officinalis on the regulation of muscle function and metabolism.…”

Section: Introductionmentioning

confidence: 99%

The Oral Administration of Sanguisorba officinalis Extract Improves Physical Performance through LDHA Modulation

et al. 2021

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Muscle fatigue is induced by an acute or chronic physical performance inability after excessive physical activity often associated with lactate accumulation, the end-product of glycolysis. In this study, the water-extracted roots of Sanguisorba officinalis L., a herbal medicine traditionally used for inflammation and diarrhea, reduced the activities of lactate dehydrogenase A (LDHA) in in vitro enzyme assay myoblast C2C12 cells and murine muscle tissue. Physical performance measured by a treadmill test was improved in the S. officinalis-administrated group. The analysis of mouse serum and tissues showed significant changes in lactate levels. Among the proteins related to energy metabolism-related physical performance, phosphorylated-AMP-activated protein kinase alpha (AMPKα) and peroxisome proliferator-activated receptor-coactivator-1 alpha (PGC-1α) levels were enhanced, whereas the amount of LDHA was suppressed. Therefore, S. officinalis might be a candidate for improving physical performance via inhibiting LDHA and glycolysis.

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Sanguisorba officinalis L. promotes diabetic wound healing in rats through inflammation response mediated by macrophage

Song

Zeng

Zheng

et al. 2023

Phytotherapy Research

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Sanguisorba officinalis L., a traditional Chinese medicine, is frequently used to treat burns and scalds. But even so, it is unknown whether S. officinalis L. can accelerate diabetic wounds (DW) healing. Here, to bridge the gap, we employed in vivo and in vitro evaluations to assess the positive effect of S. officinalis L. ethanol extract (ESO) on DW. Results demonstrated that ESO dramatically improved the DW healing rate. With ESO treatment, the inappropriately elevated levels of IL6, IL1β and TNFα in DW were reduced, while the expression of IL10 was increased, indicating that the abnormal inflammation in DW was also under control. Moreover, the abnormally elevated expression of CD86 was significantly inhibited and the expression of CD206 was significantly up‐regulated following treatment with ESO. The global level of NF‐κB protein was not affected by ESO treatment, but it suppressed the expression of phosphorylated NF‐κB and prevented its nuclear entry. In addition, in RAW264.7 cells activated with lipopolysaccharide (LPS), the expression of NLRP3, Caspase1 and IL1β were significantly diminished following ESO treatment. In conclusion, ESO was proved to be a promising treatment for DW healing due to its potential to accelerate the healing process by suppressing the inflammatory response. This was achieved by increasing the ratio of M2 to M1 polarization through blocking the NF‐κB/NLRP3 signaling pathway.

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Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages

Cited by 25 publications

References 60 publications

A Comprehensive Review of Genus Sanguisorba: Traditional Uses, Chemical Constituents and Medical Applications

A Comprehensive Review of Genus Sanguisorba: Traditional Uses, Chemical Constituents and Medical Applications

The Oral Administration of Sanguisorba officinalis Extract Improves Physical Performance through LDHA Modulation

Sanguisorba officinalis L. promotes diabetic wound healing in rats through inflammation response mediated by macrophage

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