Digital human models (DHM) allow for a proactive ergonomic assessment of products by applying different models describing the user-product interaction. In engineering design, DHM tools are currently not established as computer-aided ergonomics tools, since (among other reasons) the interaction models are either cumbersome to use, unstandardised, time-demanding or not trustworthy. To understand the challenges in interaction modelling, we conducted a systematic literature review with the aim of identification, classification and examination of existing interaction models. A schematic user-product interaction model for DHM is proposed, abstracting existing models and unifying the corresponding terminology. Additionally, nine general approaches to proactive interaction modelling were identified by classifying the reviewed interaction models. The approaches are discussed regarding their scope, limitations, strength and weaknesses. Ultimately, the literature review revealed that prevalent interaction models cannot be considered unconditionally suitable for engineering design since none of them offer a satisfactory combination of genuine proactivity and universal validity.Practitioner summary: This contribution presents a systematic literature review conducted to identify, classify and examine existing proactive interaction modelling approaches for digital human models in engineering design. Ultimately, the literature review revealed that prevalent interaction models cannot be considered unconditionally suitable for engineering design since none of them offer a satisfactory combination of genuine proactivity and universal validity.