Şap hastalığı (FMD) ve üç gün hastalıklarına (BEF) karşı eş zamanlı aşılanmış sığırlarda bağışıklık yanıt

Abstract

Bovine ephemeral fever (BEF) virus is an arthropod-borne rhabdovirus and causing an acute febrile illness disease in cattle and water buffalo. Foot-and-mouth disease (FMD) is a highly infectious viral disease of mammals and has a great potential for causing severe economic loss in susceptible cloven-hoofed animals. FMD and BEF vaccines are widely used in countries where both diseases are seen together. This study was carried out to determine the immunological response of cattle simultaneously vaccinated with BEF and FMD vaccines. For this purpose, the cattle were divided into 4 groups in this study as single FMD vaccination group (Group 1; n=10), single BEF vaccination group (Group 2; n=10), BEF+FMD simultaneously vaccinated group (Group 3; n=10) and unvaccinated control group (Group 4; n=10). After the first vaccinations, booster BEF vaccine was applied to the cattle in groups 2 and 3. Although there was no increase in the neutralizing antibody titers against BEF and FMD virus in the blood serums of unvaccinated cattle on the 30th and 60th days of vaccination, There were significant increases in statistically protective neutralizing antibody levels in the vaccinated cattle. As a result, it was demonstrated with this study that BEF and FMD vaccines can be applied simultaneously to combat both diseases in cattle.