Saphenous vein wall thickness in age and venous reflux-associated remodeling in adults

Labropoulos, Nicos; Summers, Kelli L.; Sánchez, Ignacio Escotto; Raffetto, Joseph D.

doi:10.1016/j.jvsv.2016.11.003

Cited by 32 publications

(32 citation statements)

References 34 publications

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“…The presence of DVT or PTS (adjusted r 2 = 0.797) had the highest impact ( B ‐values: 0.26, 95% CI 0.24–0.26 [DVT]; 0.47, 95% CI 0.45–0.49 [PTS]) on wall thickening. An age‐dependent increase in the wall thickness of the great saphenous vein was documented in a recent article from our center . These results suggest an age‐dependent increase in venous wall remodeling leading to thicker and stiffer veins.…”

Section: Resultssupporting

confidence: 67%

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Vein wall remodeling in patients with acute deep vein thrombosis and chronic postthrombotic changes

Chandrashekar

Garry

Gasparis

et al. 2017

Journal of Thrombosis and Haemostasis

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Introduction A few studies have investigated venous wall remodeling after venous thrombosis by using rodent models. Such information is lacking in humans. This study was designed to determine the acute and chronic effects of thrombus on the vein wall. Methods Patients aged > 16 years with deep vein thrombosis diagnosed by duplex ultrasound were assessed by the use of case-control methodology. Those with recurring thrombotic episodes, cardiorespiratory disease, terminal cancer, morbid obesity, penetrating trauma or significant inflammation were excluded. High-resolution ultrasound was employed to determine wall thickness, with strict quality criteria and inclusion of only technically adequate ultrasound images. Results Data were collected from patients with acute thrombosis (35), patients with chronic postthrombotic changes (15), and unaffected controls (32), with 853 total vein segments being analyzed. As compared with controls (mean 0.37 mm; 95% confidence interval [CI] 0.37-0.38 mm), venous wall thickness was increased in acute (mean 0.63 mm; 95% CI 0.61-0.64 mm) and postthrombotic (mean 0.85 mm; 95% CI 0.80-0.91 mm) venous segments. Ipsilateral, contralateral and unaffected control vein segments were not different. Ipsilateral segments were thicker than controls in postthrombotic syndrome (PTS) patients, but not in acute patients. Multiple regression analyses demonstrated small impacts of age and sex on vein wall thickness. Conclusions Wall thickness increases in all lower-tcglimb venous segments of patients with acute and postthrombotic disease. Age and sex may affect wall thickness, although further investigation is required to clarify their impact. The equivalence of ipsilateral and unaffected control segments suggests that acute vein wall remodeling is mediated through direct interaction with the thrombus, whereas remodeling in PTS patients may be affected by other factors.

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Section: Resultssupporting

confidence: 67%

“…Multiple regression analysis among control patients indicated a weak association (adjusted r 2 = 0.31) with a [7]. These results suggest an age-dependent increase in venous wall remodeling leading to thicker and stiffer veins.…”

Section: Resultsmentioning

confidence: 82%

Vein wall remodeling in patients with acute deep vein thrombosis and chronic postthrombotic changes

Chandrashekar

Garry

Gasparis

et al. 2017

Journal of Thrombosis and Haemostasis

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“…Differences between breeds, as well as relationships between jugular vein diameter and morphometric measures, has been detected in cows [4] and might exist in horses. Also, ageing, as demonstrated in human beings and laboratory models, produces morphofunctional changes in veins, by inducing a reduced vasoconstrictive response, abnormal compliance and wall thickening, as well as reduction of the cross-sectional area [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic assessment of normal jugular veins in Standardbred horses

et al. 2019

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Background: Ultrasonography (US) is the recommended imaging technique to evaluate jugular veins. This prospective randomized clinical study was designed to collect a series of B-mode US measurements of manually distended jugular veins in healthy Italian Standardbreds and to find possible correlations between ultrasound measurements and animal morphometric characteristics. Forty-two horses, eight males and 34 females (range 3-22 years; bodyweight 494.4 ± 41.7 kg), were included in the study. The diameters and wall thicknesses of both jugular veins were measured at three different sites of the neck. The differences in ultrasound measurements based on scans, age, gender, side, and site of the neck were evaluated by ANOVA or by the Kruskal-Wallis test. The effects of the morphometric measures on each ultrasound parameter were evaluated by MANOVA (P < 0.05). Results: The ultrasound measurements did not differ significantly between the three different sites or between genders; hence, they were pooled together in the results. On the transverse scan, the mean dorsoventral and lateromedial diameters were 1.58 ± 0.23 and 2.20 ± 0.25 cm, respectively; the mean superficial and deep wall thicknesses (SWT and DWT) were 0.07 ± 0.01 and 0.08 ± 0.01 cm, respectively. On the longitudinal scan, the mean dorsoventral diameter was 1.59 ± 0.26 cm, and the SWT and DWT were both 0.08 ± 0.01 cm. Neck length, from the caudal edge of the mandible to the thoracic inlet, was related to the dorsoventral diameter in both longitudinal and transverse scan and to the SWT and DWT in transverse scan, whereas height at the withers (measured with tape) and estimated weight were related to the wall thickness. Dividing the subjects into groups by age in years ("young" 3-7, "mature" 8-14, "old" > 14), differences were found for the lateromedial diameter in the transverse scan and the SWT on the longitudinal scan. The main limitation of this study was that only one operator performed the measurements. Conclusion: The US measurements of the jugular veins and their relationship with morphometric measures reported in this manuscript might be considered as guidelines both for early diagnosis and monitoring jugular vein abnormalities in healthy Italian Standardbred horses.

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“…The above-mentioned characteristics and properties are summarized in Table 1 for two representative blood vessels. (Johnson, 2015) human saphenous vein 2.5 -6.5 (Engelhorn et al, 2017) 0.3-0.6 (Labropoulos et al, 2017) 1.1 0.17-0.25 200 (Johnson, 2015, Neufurth et al, 2015…”

Section: Native Blood Vesselsmentioning

confidence: 99%

Tissue engineered vascular grafts

2018

Biomater Tissue Eng Bull

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With the continuous increase in the prevalence of cardiovascular diseases and the limited efficiency of conventional treatments, including diet and lifestyle modifications, pharmaceutical administration, and surgical interventions, there is an equally increased need for vascular grafts for the replacement of damaged blood vessels. Currently, autologous grafts represent the gold standard. However, due to the limited availability, intensive work has been performed in the field of vascular tissue engineering. Although there are many possibilities for obtaining synthetic vascular grafts, there is still no ideal solution for vascular replacements. In this paper, the main material categories and fabrication techniques are reviewed.

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Saphenous vein wall thickness in age and venous reflux-associated remodeling in adults

Cited by 32 publications

References 34 publications

Vein wall remodeling in patients with acute deep vein thrombosis and chronic postthrombotic changes

Vein wall remodeling in patients with acute deep vein thrombosis and chronic postthrombotic changes

Ultrasonographic assessment of normal jugular veins in Standardbred horses

Tissue engineered vascular grafts

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