SAPHO syndrome with affection of the mandible: diagnosis, treatment, and review of literature

Zemann, Wolfgang; Pau, Mauro; Feichtinger, Matthias; Ferra-Matschy, Barbara; Kaercher, H.

doi:10.1016/j.tripleo.2010.04.037

Cited by 36 publications

(30 citation statements)

References 27 publications

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“…Recurrent multifocal osteomyelitis in the absence of skin disease [15]. In etwa 3 -7,5 % der Fälle kann es zu einer chronisch entzündlichen Darmerkrankung kommen, wobei der Morbus Crohn häufiger als die Colitis ulcerosa ist [9].…”

Section: Rezidivierende Multifokale Osteomyelitis Ohne Dermatoseunclassified

Rezidivierende multifokale Osteomyelitis ohne Dermatose

Lamparter¹,

List-Hellwig²,

Basten³

2013

Dtsch med Wochenschr

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Section: Rezidivierende Multifokale Osteomyelitis Ohne Dermatoseunclassified

Rezidivierende multifokale Osteomyelitis ohne Dermatose

Lamparter¹,

List-Hellwig²,

Basten³

2013

Dtsch med Wochenschr

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“…To date its etiology has remained unknown [2][3][4][5] SAPHO syndrome is a rheumatic disease belonging to the group of spondyloarthropathies and combining osteomyelitis, osteitis, arthritis and skin disease [1,[5][6][7][8][9]. Its diagnosis can be made with the aid of three diagnostic criteria classified by Kahn et al [10] ( Table 1).…”

Section: Introductionmentioning

confidence: 99%

“…The most commonly affected bones are the clavicle and the sternum, but manifestations can also be seen on long tubular and tarsal bones, as well as the spine and ribs [2,3,8,9]. Involvement of the mandible has also been described in approximately 10% of cases [2,4,9,11]. However, as the bone and skin lesions, like palmoplantar pustulosis, do not necessarily emerge at the same time, making an appropriate diagnosis of the syndrome can be difficult and challenging [9,12].…”

Section: Introductionmentioning

confidence: 99%

Implication of bisphosphonate use in the treatment of SAPHO syndrome: Case report and discussion of current literature

Gorecki

Stockmann

Distler

et al. 2015

Journal of Medical Hypotheses and Ideas

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Even though increasing knowledge is emerging about synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome its pathogenesis remains enigmatic. Women are preferentially affected by SAPHO syndrome. Here we present the case of a 39-year-old woman suffering from this syndrome whose bone involvement was first interpreted as diffuse sclerosing osteomyelitis of the mandible. As treatment with clindamycin did not improve the symptoms, the decision was made to administer bisphosphonates intravenously. This treatment led to a rapid improvement in symptoms, which could be explained by the apparent tendency of bisphosphonates to exert a positive effect on the jaw. With this case report we attempt to offer an explanation for the influence of this group of medications on patients suffering from SAPHO syndrome with mandibular involvement.

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“…10% of cases. Usually changes occur unilaterally, mainly in the distal parts of the mandibular body and branch [5,20]. They are often accompanied with painful edema of the surrounding soft tissues [9].…”

mentioning

confidence: 99%

“…They are often accompanied with painful edema of the surrounding soft tissues [9]. A change affecting the mandibular bone can be isolated or coexist with osseous manifestations in other parts of the skeleton [4,7,11,16,20].…”

mentioning

confidence: 99%