SAPHO syndrome with enthesopathy

Su, Chin-Fang; Shen, Yu–Chuan; Liao, Hsien‐Tzung; Tsai, Chang‐Youh

doi:10.1136/bcr-2018-225929

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…Fourth, the patients were heterogeneous in terms of disease duration and treatment. Most patients had a complex medical history and treatment process, which may lead to heterogeneous manifestations [15]. Last, future studies should incorporate patient reported outcomes (such as magnitude of pain and upper extremity function) to better understand the clinical relevance of the MRI findings.…”

Section: Discussionmentioning

confidence: 99%

“…Magnetic resonance imaging (MRI) is the only method that can detect bone marrow edema (BME) and soft tissue involvement [11]. However, only a few prior reports have specifically investigated the MRI abnormalities of the ACW in SAPHO patients [12][13][14][15]. The aim of our study was to characterize the MRI findings of ACW involvement in SAPHO patients so as to facilitate the understanding of the imaging features and pathogenesis of the disease.…”

Section: Introductionmentioning

confidence: 99%

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Anterior chest wall in SAPHO syndrome: magnetic resonance imaging findings

Cao

et al. 2020

Arthritis Res Ther

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Background The anterior chest wall (ACW) involvement is characteristic of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, yet little research has focused on its magnetic resonance imaging (MRI) findings. Purpose To characterize the MRI features of the ACW in patients with SAPHO syndrome. Methods Seventy-one patients with SAPHO syndrome and ACW involvement evidenced by bone scintigraphy were recruited in this cross-sectional study. The ACW region was scanned using sagittal, axial, and oblique coronal Dixon T2-weighted sequences and axial Dixon T1-weighted sequences. The characteristics of both active inflammatory and chronic structural lesions were evaluated. Results The ACW lesions exhibited an asymmetrical distribution and a predilection for the sternocostoclavicular region (93.0%). Notably, 91.5% of the patients had lesions in the area of the anterior first ribs. Bone marrow edema (BME) was observed in 63 (88.7%) patients, which mainly affected the sternocostal joints (87.3%) and the manubrium sterni (84.5%). All of the BMEs were distributed under the articular surface or the bone cortex, consistent with the distribution of the ligaments and joint capsules. Synovitis was detected in 64 (90.1%) patients, with a predilection for the sternoclavicular joints (76.1%). A soft tissue mass or infiltration was found in all the patients who had bone marrow edema. Thirteen (18.3%) patients showed venous stenosis. Structural changes included bone bridge formation (80.3%), hyperostosis (43.7%), and fat infiltration (39.4%). Four common patterns of involvement were observed: the first rib area, the sternoclavicular area, the sternal angle area, and the areas of the second to sixth sternocostal joints. Conclusion The ACW lesions of SAPHO syndrome demonstrated a triad of enthesitis, synovitis, and osteitis, suggesting complex interactions among the ligaments, synovium, and bones in the region. The inflammatory changes in the first rib area were highlighted in SAPHO syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anterior chest wall in SAPHO syndrome: magnetic resonance imaging findings

Cao

et al. 2020

Arthritis Res Ther

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“…NSAIDs are considered to be the first-line drugs for pain relief in patients with SAPHO syndrome. Su et al ( 12 ) reported a 59-year-old female patient who was diagnosed with SAPHO syndrome. Antibiotics used to treat SAPHO were ineffective.…”

Section: Discussionmentioning

confidence: 99%

Percutaneous vertebroplasty for SAPHO syndrome with vertebral destruction: a case report and literature review

Cheng

Feng

et al. 2023

Front. Med.

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Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare musculoskeletal disease characterized by dermatological and osteoarticular lesions. However, SAPHO syndrome is difficult to be diagnosed due to the rarity and complexity. Additionally, there is no standard treatment for SAPHO syndrome based on limited experience. Percutaneous vertebroplasty (PVP) has rarely been reported to treat SAPHO syndrome. We reported a 52-year-old female patient who had a sex-month history of back pain. Palmoplantar pustulosis appeared on the hands and feet. Vertebral destruction was observed on computed tomography (CT) scanning. Laboratory examination showed that erythrocyte sedimentation rate (ESR) and C-reactive protein were elevated. Finally, the patient was diagnosed with SAPHO syndrome and treated with PVP. After the surgery, the back pain was significantly relieved. In this study, we mainly discussed the treatment methods of SAPHO syndrome, and provided a potential treatment for SAPHO syndrome, especially with vertebral destruction, kyphosis, and even pathological fractures.

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Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: review and update

Liu

Tang

Cao

et al. 2020

Therapeutic Advances in Musculoskeletal

105

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Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a spectrum of heterogeneous diseases characterized by osteoarticular and dermatological manifestations. Osteitis and hyperostosis are core clinical manifestations in SAPHO syndrome, typically affecting multiple areas and possibly progressing to irreversible osteoarticular damage. Most patients with SAPHO have cutaneous involvement, mainly manifested as palmoplantar pustulosis and severe acne. Systemic manifestations are uncommon but occasionally reported. Epidemiological studies suggest the annual prevalence of SAPHO syndrome varies from 0.00144 in 100,000 in Japanese individuals to fewer than 1 in 10,000 in White individuals. The precise etiopathogenesis of SAPHO remains unclear, but it is generally considered an autoinflammatory syndrome that may be related to various etiologies, such as immune dysfunction, infection and genetic predisposition. Owing to the relapsing–remitting disease course, the goal of management is to improve clinical symptoms and prevent disease progression. Various treatments, including nonsteroidal anti-inflammatory drugs, conventional disease-modifying antirheumatic drugs, bisphosphonates, biologics, and antibiotics, are promising options for alleviating the disease.

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SAPHO syndrome with enthesopathy

Cited by 3 publications

References 11 publications

Anterior chest wall in SAPHO syndrome: magnetic resonance imaging findings

Anterior chest wall in SAPHO syndrome: magnetic resonance imaging findings

Percutaneous vertebroplasty for SAPHO syndrome with vertebral destruction: a case report and literature review

Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: review and update

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