Saponin Detoxification and Fungal Pathogenesis

Osbourn, Anne; Melton, Rachel E.; Wubben, J.P.; Flegg, Lynda M.; Oliver, Richard P.; Daniels, Michael J.

doi:10.1007/978-94-011-5218-1_35

Cited by 4 publications

(1 citation statement)

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“…Phytopathogenic fungi have developed numerous mechanisms over time to overcome the chemical barriers posed by their hosts. The main strategy is the enzyme detoxification of toxic compounds [ 112 ], which plays a key role in the success of host colonization [ 113 ]. The most studied example is the use of a stilbene oxidase, which is a substrate-specific laccase used to detoxify the phytoalexins resveratrol and pterostilbene and which allows the fungus to oxidize these compounds into harmless configurations [ 114 ].…”

Section: Botrytis Cinereamentioning

confidence: 99%

Challenges and Opportunities Arising from Host–Botrytis cinerea Interactions to Outline Novel and Sustainable Control Strategies: The Key Role of RNA Interference

Spada,

Pugliesi,

Fambrini

et al. 2024

IJMS

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The necrotrophic plant pathogenic fungus Botrytis cinerea (Pers., 1794), the causative agent of gray mold disease, causes significant losses in agricultural production. Control of this fungal pathogen is quite difficult due to its wide host range and environmental persistence. Currently, the management of the disease is still mainly based on chemicals, which can have harmful effects not only on the environment and on human health but also because they favor the development of strains resistant to fungicides. The flexibility and plasticity of B. cinerea in challenging plant defense mechanisms and its ability to evolve strategies to escape chemicals require the development of new control strategies for successful disease management. In this review, some aspects of the host-pathogen interactions from which novel and sustainable control strategies could be developed (e.g., signaling pathways, molecules involved in plant immune mechanisms, hormones, post-transcriptional gene silencing) were analyzed. New biotechnological tools based on the use of RNA interference (RNAi) are emerging in the crop protection scenario as versatile, sustainable, effective, and environmentally friendly alternatives to the use of chemicals. RNAi-based fungicides are expected to be approved soon, although they will face several challenges before reaching the market.

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Section: Botrytis Cinereamentioning

confidence: 99%