Saponin rich fractions from Polygonatum odoratum (Mill.) Druce with more potential hypoglycemic effects

Deng, Yafei; He, Kai; Yang, Xiaoli; Chen, Xin; Huang, Jing; Li, Xuegang; Yuan, Lujiang; Jin, Yalan; Jin, Qing; Li, Panpan

doi:10.1016/j.jep.2012.02.023

Cited by 79 publications

(39 citation statements)

References 26 publications

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“…[14]. Polysaccharides are the major bioactive compounds in these plants [38][39][40][41]. Phytochemical and pharmacological research on several species including P. odoratum, P. verticillatum, P. cyrtonema, P. kingianum have been reported.…”

Section: Medicinal Effectmentioning

confidence: 99%

Ethnobotanical review of food uses of Polygonatum (Convallariaceae) in China

Wujisguleng

Liu

2012

Acta Soc Bot Pol

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According to our literature survey, fifteen species in the genus Polygonatum (Convallariaceae) have been used as food in China. Five main categories of use (drinks, snacks, vegetables, staple food and seasoning) were found. The plants from this genus are used mainly as vegetables. Rhizomes are the main parts used. The categories of use and diverse preparation methods have some similarities with those in other countries. Among all the recorded species, Polygonatum sibiricum and P. odoratum are the most commonly consumed species in China. Local people from different places have their own unique preparation methods and customs. However, the use of Polygonatum still remains at the level of family consumption, and the resources have not been fully used yet. We proposed ideas for further exploitation and conservation of edible Polygonatum species, and suggested fur- ther research, e.g. on the nutritional properties of all recorded edible species. It is believed that there is still plentiful traditional knowledge about food uses of Polygonatum to be documented in China

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Section: Medicinal Effectmentioning

confidence: 99%

Ethnobotanical review of food uses of Polygonatum (Convallariaceae) in China

Wujisguleng

Liu

2012

Acta Soc Bot Pol

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“…In a rat study comparing antidiabetic effects of saponin rich and flavonoid rich fractions from Yuzhu, the former was found to be more effective in reducing blood glucose, the flavonoid rich fraction was more effective in enhancing superoxide dismutase (SOD) activity and reducing malondialdehyde (MDA) level [15].…”

Section: Pharmacological Studiesmentioning

confidence: 99%

“…Recent evidence revealed its bioactive components saponins and flavonoids might prevent or reduce body damage or diabetic complications from diabetes [15].…”

Section: Clinical Evidencesmentioning

confidence: 99%

Polygonatum odoratum (Mill.) Druce 玉竹 (Yuzhu)

Liu

2015

Dietary Chinese Herbs

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“…Previous studies have demonstrated that it increases the level of antibody production, and exerts anti-inflammatory, antiviral and tumor inhibitory effects (27,28). P. odoratum has been used to treat various diseases due to its procoagulant activity (29), anti-hyperglycemic effect (30,31), glucose tolerance improvement (32) and anti-herpes simplex virus-II and apoptosis-inducing activities (33). P. odoratum has been suggested as a potential therapeutic target for the treatment of breast cancer (34,35).…”

Section: Introductionmentioning

confidence: 99%

Effect of Polygonatum odoratum extract on human breast cancer MDA-MB-231 cell proliferation and apoptosis

Tai

Sun

Zou

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Traditional Chinese medicine (TCM) is important in the provision of anti-tumor drugs. Recently, studies have shown that certain types of TCM agents are able to control the growth of tumors, enhance the body's immune function and enhance the therapeutic effect of chemotherapeutic drugs. In women, breast carcinoma is the most common tumor type and the second most common cause of death from cancer. Polygonatum odoratum (P. odoratum) is commonly used in TCM. The aim of the present study was to investigate the effects of P. odoratum extract on the proliferation and apoptosis of MDA-MB-231 breast cancer cells. Cell proliferation was assessed using MTT and colony formation assays. In addition, propidium iodide (PI)/Annexin V-FITC staining was used to investigate the apoptosis of MDA-MB-231 cells following treatment with P. odoratum extract. The protein expression levels of B-cell lymphoma-2 (Bcl-2) and Bcl-2-associated X protein (Bax) were also detected using western blot analysis, while a JC-1 staining assay was used to assess the mitochondrial membrane potential (ΔΨm). The results of the MTT assay showed that the proliferation and colony formation of MDA-MB-231 cells were inhibited following treatment with the extract. Furthermore, the PI/Annexin-V staining showed that the apoptosis of MDA-MB-231 cells was enhanced by the extract, in a concentration-dependent manner. The extract also lowered the ΔΨm of MDA-MB-231 cells, upregulated the expression of Bax and inhibited the expression of Bcl-2. In conclusion, these results showed that the P. odoratum extract inhibited the proliferation and induced apoptosis of breast cancer MDA-MB-231 cells.

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Saponin rich fractions from Polygonatum odoratum (Mill.) Druce with more potential hypoglycemic effects

Cited by 79 publications

References 26 publications

Ethnobotanical review of food uses of Polygonatum (Convallariaceae) in China

Ethnobotanical review of food uses of Polygonatum (Convallariaceae) in China

Polygonatum odoratum (Mill.) Druce 玉竹 (Yuzhu)

Effect of Polygonatum odoratum extract on human breast cancer MDA-MB-231 cell proliferation and apoptosis

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