Saponins and flavonoids from Bacopa floribunda plant extract exhibit antioxidant and anti-inflammatory effects on amyloid beta 1-42-induced Alzheimer's disease in BALB/c mice

Oyeleke, Mosunmola B.; Owoyele, Bamidele Victor

doi:10.1016/j.jep.2022.114997

Cited by 24 publications

(18 citation statements)

References 119 publications

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“…It is well known that flavonoids can resist oxidation and improve cell activity. Many studies have proved that flavonoids have antioxidant and anti-inflammatory effects on AD [ 35 – 37 ]. After taking Hengqing II, the relative contents of daidzein, genistein, and naringenin increased significantly, which may help patients reverse the pathology of AD.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects and Metabolic Spectrum of Traditional Chinese Medicine Hengqing II Prescription on Alzheimer’s Disease

Meng

Li²,

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Alzheimer’s disease (AD) seriously damages elders’ social and daily abilities around the world. Traditional Chinese medicine (TCM), a rich drug resource bank, could help research AD. In order to explore the role of TCM in AD treatment, 86 AD patients were recruited from the hospital, then treated with Hengqing II prescription and donepezil hydrochloride. The cognitive and serum lipid levels were investigated before and after treatment. The patient’s urine was collected after three months of treatment. Metabolites in the urine samples were extracted with methanol and detected on the UHPLC-MS platform. Results proved that Hengqing II can improve cognitive levels and reduce the levels of Hcy, D-D, FIB, Apo B, TC, and LDL-C compared with donepezil hydrochloride ( P < 0.05 ). The results of multivariate statistical analysis revealed that the metabolism of HQII was significantly different compared with Control groups. A total of 66 differential metabolites were found in this comparison (50 were down-regulated and 16 were up-regulated). Four amino acid pathways and one linoleic acid pathway were found through these metabolites. After receiver operating characteristic analysis, it was suggested that palmitic acid, palmitoleic acid, linoleic acid, oleic acid, SAH, and methionine can be used as biomarkers for treating AD, while the effects of daidzein, genistein, and naringenin on the treatment of AD need to be further studied.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Effects and Metabolic Spectrum of Traditional Chinese Medicine Hengqing II Prescription on Alzheimer’s Disease

Meng

Li²,

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Saponin-rich plants are used for various purposes and are considered as the main ingredients in Traditional Chinese Medicine (TCM); these plants notably include ginseng [ 72 ]. Saponins exhibit diverse pharmacological properties including antioxidant, anti-neuroinflammatory and neuro-cognitive benefits [ 73 , 74 , 75 ]. Several studies reported the neuroprotective potentials of saponins.…”

Section: Saponins and Their Neuro-pharmacological Propertiesmentioning

confidence: 99%

Alzheimer’s Disease as a Major Public Health Concern: Role of Dietary Saponins in Mitigating Neurodegenerative Disorders and Their Underlying Mechanisms

et al. 2022

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Saponins are triterpenoid or steroidal glycosides and are an important group of naturally occurring compounds of plant origin. They exhibit diverse pharmacological potentials including radical scavenging, as well as neuroprotective, anti-diabetic and anti-inflammatory activities, owing to their diverse chemical scaffolds. Saponins consist of an aglycone part (non-sugar) and a glycone part (sugar) and have at least one glycosidic (C–O sugar bond) linkage present between the glycone and aglycone mostly at C-3. On the basis of the aglycone part, saponins are classified into triterpenoid glycosides, steroid glycosides and alkaloid glycosides. Saponins exhibit neuroprotective activities against various disorders of the central nervous system (CNS) including stroke, Alzheimer’s disease (AD), Huntington’s disease (HD) and Parkinson’s disease (PD). They mediate their therapeutic effects by modulation of various pathological targets. This study highlights various neuroprotective mechanisms of saponins including free radical scavenging, modulation of neuroprotective signaling pathways, activation of neurotrophic factors, modulation of neurotransmitters, inhibition of BACE1 enzyme and tau hyper-phosphorylation. The study concludes that saponins have considerable efficacy against various pathological targets of neurological disorders, especially AD, and might be an important source of leads against neurodegenerative disorders.

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“…Radiation induced aging models are usually used in cancer treatment (radiotherapy) related aging researches ( 29 ). Application of β-amyloid and aluminum chloride induces brain disorders, and these models are usually applied in Alzheimer's Disease related studies ( 30 , 31 ). In recent years, transgenic aging models gain more and more attention with the development of gene editing technologies.…”

Section: Aging Liver: Suitable Animal Modelsmentioning

confidence: 99%

Understanding the Unique Microenvironment in the Aging Liver

Zhao

Yang

et al. 2022

Front. Med.

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In the past decades, many studies have focused on aging because of our pursuit of longevity. With lifespans extended, the regenerative capacity of the liver gradually declines due to the existence of aging. This is partially due to the unique microenvironment in the aged liver, which affects a series of physiological processes. In this review, we summarize the related researches in the last decade and try to highlight the aging-related alterations in the aged liver.

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Saponins and flavonoids from Bacopa floribunda plant extract exhibit antioxidant and anti-inflammatory effects on amyloid beta 1-42-induced Alzheimer's disease in BALB/c mice

Cited by 24 publications

References 119 publications

Therapeutic Effects and Metabolic Spectrum of Traditional Chinese Medicine Hengqing II Prescription on Alzheimer’s Disease

Therapeutic Effects and Metabolic Spectrum of Traditional Chinese Medicine Hengqing II Prescription on Alzheimer’s Disease

Alzheimer’s Disease as a Major Public Health Concern: Role of Dietary Saponins in Mitigating Neurodegenerative Disorders and Their Underlying Mechanisms

Understanding the Unique Microenvironment in the Aging Liver

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