Saponins are involved in the analgesic and anti-inflammatory properties of &lt;i&gt;Ficus platyphylla&lt;/i&gt; stem bark

Chindo, Ben A.; Anuka, J. A.; Isaac, Edmond; Ahmadu, AA; Tarfa, Florence D.; Gamaniel, K.

doi:10.4314/ijbcs.v4i2.58140

Cited by 9 publications

(6 citation statements)

References 29 publications

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“…Prostaglandins are involved in pain perception; therefore, agents that inhibit their synthesis are possible remedies for pain. Several studies have also revealed that alkaloids, saponins and terpenoids do possess antinociceptive properties [34,[40][41][42] The present study therefore suggests that the antinociceptive effect of the methanolic bark extracts of T. brownii could be due to the activity flavonoids, alkaloids, terpenoids and saponins that have been confirmed to be present in this medicinal plant. One limitation of this study is that biochemical tests were not conducted to determine the effects of the methanolic bark extract of T. brownii on internal organs like the liver and the kidney.…”

Section: Discussionmentioning

confidence: 66%

Antinociceptive Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats

Mbiri¹,

Kasili²,

Kisangau³

et al. 2016

J Pain Relief

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Section: Discussionmentioning

confidence: 66%

Antinociceptive Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats

Mbiri¹,

Kasili²,

Kisangau³

et al. 2016

J Pain Relief

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“…Bioactive compounds such as flavonoids, alkaloids, saponins, phenols, and cardiac glycosides found in the extracts have been found to possess analgesic and anti-inflammatory properties in previous studies. Numerous studies have shown that alkaloids possess analgesic and anti-inflammatory properties [29,30]. Flavonoids also show analgesic and anti-inflammatory activity by inhibiting prostaglandin synthetase, which in turn reduces prostaglandin synthesis and release [31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Acute Toxicity, Phytochemical Screening, Analgesic, and Anti-Inflammatory Activities of Aqueous and Methanol Root Extracts of Maerua triphylla A. Rich. (Capparaceae)

Wangusi

Kanja

Ole-Mapenay

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Maerua triphylla root extracts are used by Maasai and Kikuyu communities in Kenya to manage headaches, stomachaches, migraines, and rheumatism. However, scientific data on their safety and efficacy are limited. The current study aims to investigate the safety, phytochemical constituents, analgesic, and anti-inflammatory activities of M. triphylla root extracts. Aqueous and methanol M. triphylla root extracts were prepared by cold maceration, and the extracts’ safety was evaluated using Wistar rats according to the Organization for Economic Cooperation and Development (2008) guidelines. Standard qualitative phytochemical screening methods were used for the detection of various phytochemical groups in the extracts. Analgesic activity assay in Swiss albino mice was done using the acetic acid-induced writhing test, while anti-inflammatory activity was determined in Wistar rats using the acetic acid-induced paw edema method. The methanol and aqueous extracts revealed LD50 > 2000 mg/kg bw, classifying them as nontoxic. The presence of cardiac glycosides, flavonoids, alkaloids, and phenols was observed in both extracts. However, saponins were only present in the methanol extract. In the analgesic study, mice that received 100 mg/kg bw and 500 mg/kg bw of aqueous root extract of M. triphylla had significantly lower acetic acid-induced writhing than mice that received acetylsalicylic acid 75 mg (reference drug) ( p < 0.05 ). Additionally, mice that received 500 mg/kg bw of methanol root extract of M. triphylla had significantly lower acetic acid-induced writhing than mice that received the acetylsalicylic acid 75 mg ( p < 0.05 ). In the anti-inflammatory study, there was no significant difference ( p < 0.05 ) between the inhibitory activity of different doses of the aqueous root extract of M. triphylla and a 50 mg/kg dose of diclofenac sodium (reference drug) on acetic acid-induced paw edema in rats. Moreover, there was no significant difference in the inhibitory activity of 100 mg/kg bw and 500 mg/kg bw doses of the methanol root extract of M. triphylla and a 50 mg/kg dose of diclofenac sodium on acetic acid-induced paw edema ( p > 0.05 ). These findings suggest that the roots of M. triphylla may be useful in the safe mitigation of pain and inflammation and therefore support their ethnomedicinal use in the management of pain and inflammation.

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“…Since flavonoids, saponins and tannins are important secondary metabolites of NNF and have exhibited inhibitory effects on arachidonic acid metabolism and prostaglandin synthesis [38][39][40]. Therefore the results of the tail flick test and acetic acid induced writhing test strongly recommend that the mechanism of the analgesic effect of NNF is connected with the blockade of arachidonic acid metabolism and inhibition of prostaglandin synthesis.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Analgesic Activity of Nelumbo Nucifera Fruit Ethanol Extract

Rajput

Zehra

Ali

et al. 2019

Int J Pharm Pharm Sci

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Objective: Utilization of herbal remedies rich in flavonoids and vitamins have increased significantly these days to treat various disorders, thus existing research work encircled to appraise the analgesic effect of Nelumbo nucifera fruit (NNF) for evaluating its traditional use pharmacologically in disorders which are associated with pain and inflammation. Methods: Central analgesic activity in mice was assessed by tail flick test and the latency time i.e. the removal of tail from the stimulus was recorded. Similarly acetic acid induced writhing test was also conducted for the assessment of peripheral analgesic effect in mice and number of writhes was counted along with percent inhibition of writhes. Results: In tail flick test the peek anti-nociceptive effect at all doses of fruit was observed at 90 min. However, the percentage of tail elongation time was highest at a dose of 200 mg/kg i.e. 82% at 90 min. Number of writhes was highly significantly reduced at all doses of NNF but maximum effects were observed at dose 200 mg/kg as compared to control, indicating 48.41 % inhibition of writhes. Conclusion: NNF have exhibited strong analgesic effect in both animal models, which may be connected with the synergistic actions of flavonoids, saponins and tannins on arachidonic acid pathway inhibition. Hence NNF seems to have a great potential in disorders associated with pain but more experimental trials in this field are required to confirm these findings.

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Saponins are involved in the analgesic and anti-inflammatory properties of <i>Ficus platyphylla</i> stem bark

Cited by 9 publications

References 29 publications

Antinociceptive Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats

Antinociceptive Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats

Acute Toxicity, Phytochemical Screening, Analgesic, and Anti-Inflammatory Activities of Aqueous and Methanol Root Extracts of Maerua triphylla A. Rich. (Capparaceae)

Assessment of Analgesic Activity of Nelumbo Nucifera Fruit Ethanol Extract

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