Saponins can cause the agglutination of phospholipid vesicles

Fukuda, Kayoko; Utsumi, Hideo; Shoji, Jun; Hamada, Akira

doi:10.1016/0005-2736(85)90113-0

Cited by 30 publications

(14 citation statements)

References 20 publications

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“…With a higher concentration (12.5 pgml-') we noted an activity on the cell envelope involving the integration of polysaccharidic material. Saponins are known to interact with phospholipids [13] and sterols [14,15], some promoted perforations in the plasma membrane with a massive loss of proteins [ 16). Therefore saponins may have acted on Candida albicans plasmalemma and consequently on the cell wall.…”

Section: Discussionmentioning

confidence: 99%

Study of the action of α‐hederin on the ultrastructure of Candida albicans

Moulin‐Traffort¹,

Favel

Élias

et al. 1998

Mycoses

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alpha-Hederin, a saponin isolated from Hedera helix (L.) (Araliaceae), was tested on Candida albicans ultrastructure. The concentrations used were 6.25, 12.5, and 25 micrograms ml-1 for an exposure time of 24 h. Transmission electron microscopy observations indicated that compared with untreated control yeasts, alpha-hederin induced modifications of cellular contents and alterations of cell envelope with degradation and death of the yeasts. The impact of alpha-hederin on the biomembranes and in particular on the plasmalemma is discussed. The antifungal activity of alpha-hederin was confirmed, as was the minimal inhibitory concentration (25 micrograms ml-1).

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Section: Discussionmentioning

confidence: 99%

Study of the action of α‐hederin on the ultrastructure of Candida albicans

Moulin‐Traffort¹,

Favel

Élias

et al. 1998

Mycoses

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“…Carbohydrate chain length was shown to influence the manifestation of physiological activity of oligosides (Kuznetzova et al 1982). Steroid and triterpenoid saponins with a single sugar chain (monodesmosides) were found to have strong haemolytic activity, whereas those with two sugar chains (bidesmosides) showed less activity (Fukuda et al 1985;Woldemichael & Wink, 2001). Even though monodesmoside saponins are generally considered to be more active than bidesmosides, there are exceptions.…”

Section: Effects On Cell Membranesmentioning

confidence: 99%

The biological action of saponins in animal systems: a review

et al. 2002

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Saponins are steroid or triterpenoid glycosides, common in a large number of plants and plant products that are important in human and animal nutrition. Several biological effects have been ascribed to saponins. Extensive research has been carried out into the membrane-permeabilising, immunostimulant, hypocholesterolaemic and anticarcinogenic properties of saponins and they have also been found to significantly affect growth, feed intake and reproduction in animals. These structurally diverse compounds have also been observed to kill protozoans and molluscs, to be antioxidants, to impair the digestion of protein and the uptake of vitamins and minerals in the gut, to cause hypoglycaemia, and to act as antifungal and antiviral agents. These compounds can thus affect animals in a host of different ways both positive and negative.

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“…The effects of saponins, which are used in a variety of ways, are all based on their amphiphilic structure. This structure allows saponins, on the one hand, to interact with biological and artificial membranes [14][15][16] and on the other hand to self-assemble in solution [15,17]. The micelle formation of specific saponins was examined by different groups in terms of the critical micelle concentration (cmc) [4,18,19] and shape of the micelles [20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Self-Assembly of the Bio-Surfactant Aescin in Solution: A Small-Angle X-ray Scattering and Fluorescence Study

Dargel

Geisler

Hannappel

et al. 2019

Colloids and Interfaces

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This work investigates the temperature-dependent micelle formation as well as the micellar structure of the saponin aescin. The critical micelle concentration ( c m c ) of aescin is determined from the concentration-dependent autofluorescence (AF) of aescin. Values between c m c aescin , AF (10 ∘ C) = 0.38 ± 0.09 mM and c m c aescin , AF (50 ∘ C) = 0.32 ± 0.13 mM were obtained. The significance of this method is verified by tensiometry measurements. The value determined from this method is within the experimental error identical with values obtained from autofluorescence ( c m c aescin , T ( WP ) (23 ∘ C) = 0.33 ± 0.02 mM). The structure of the aescin micelles was investigated by small-angle X-ray scattering (SAXS) at 10 and 40 ∘ C. At low temperature, the aescin micelles are rod-like, whereas at high temperature the structure is ellipsoidal. The radii of gyration were determined to ≈31 Å (rods) and ≈21 Å (ellipsoid). The rod-like shape of the aescin micelles at low temperature was confirmed by transmission electron microscopy (TEM). All investigations were performed at a constant pH of 7.4, because the acidic aescin has the ability to lower the pH value in aqueous solution.

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Saponins can cause the agglutination of phospholipid vesicles

Cited by 30 publications

References 20 publications

Study of the action of α‐hederin on the ultrastructure of Candida albicans

Study of the action of α‐hederin on the ultrastructure of Candida albicans

The biological action of saponins in animal systems: a review

Self-Assembly of the Bio-Surfactant Aescin in Solution: A Small-Angle X-ray Scattering and Fluorescence Study

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