Saponins from Climacoptera subcrassa

Kipchakbaeva, A. K.; Eskalieva, B. K.; Burasheva, G. Sh.; Adikari, A.M.N.T.; Aisa, Haji Akber; Choudhary, M. Iqbal

doi:10.1007/s10600-016-1646-z

Cited by 3 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MS gave a molecular ion peak at m/z 456 (M-H) relating to C 30 H 48 O 3 . The isomers were identified as ursolic acid (3β-hydroxyurs-12-en-28-oic acid) (1) 20 and oleanolic acid (3β-hydroxyolean-12en-28-oic acid) (2) 21 (figure 1). This study is one among others carried out on species of Combretum genus where compounds were isolated as mixtures of two isomers.…”

Section: Resultsmentioning

confidence: 99%

Isolation of two homologous triterpenes with antimalarial activities from the leaf extract of combretum zenkeri

Oluyemi¹,

Samuel²,

Kählig³

et al. 2019

actapharm

View full text Add to dashboard Cite

Combretum genus (Combretaceae) is used locally in the treatment of various diseases including malaria. Current study aimed to investigate the antiplasmodial activities of methanol extract of C. zenkeri in Plasmodium falciparum chloroquine sensitive (D10) and resistant (W2) strains and identify the bioactive principles. Repeated chromatographic separation was carried out on the chloroform fraction to afford the isolation of bioactive compounds which was characterized by application of spectroscopic techniques (ESI-MS, HR-ESIMS, 1D and 2D NMR). Antiplasmodial activities of chloroform fraction (D10; IC 50 = 12.57±1.57 μg/mL and W2; IC 50 = 12.14±0.95 μg/mL) showed more activity than the n-butanol fraction (D10; IC 50 = 61.98±3.25 μg/mL and W2; IC 50 = 61.26±8.64 μg/mL). Phytochemical investigation of the extract afforded isolation of two triterpenes with antimalarial activities. This paper identified for the first time the antimalarial principles in C. zenkeri as ursolic and oleanolic acids; which justified the local use of the plant in the treatment of malaria.

show abstract

Section: Resultsmentioning

confidence: 99%