Saponins from Panax japonicus Protect Against Alcohol-Induced Hepatic Injury in Mice by Up-regulating the Expression of GPX3, SOD1 and SOD3

Li, Yougui; Ji, Dong-Feng; Zhong, Shi; Shi, Liangen; Hu, Gui-Yan; Chen, Shi

doi:10.1093/alcalc/agq034

Cited by 62 publications

(41 citation statements)

References 24 publications

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“…The insufficiency of antioxidants result in cellular damage. The SOD plays a crucial role in cellular defense against reactive oxygen species (ROS) (Li et al 2010). The SOD neutralizes ROS to less toxic hydrogen peroxide (H 2 O 2 ) (Ding et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Supplementation of Psidium guajava (Guava) Fruit Polysaccharide Attenuates Paracetamol-induced Liver Injury by Enhancing the Endogenous Antioxidant Activity

Alias¹,

Othman²,

Li³

et al. 2015

JSM

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Section: Discussionmentioning

confidence: 99%

Supplementation of Psidium guajava (Guava) Fruit Polysaccharide Attenuates Paracetamol-induced Liver Injury by Enhancing the Endogenous Antioxidant Activity

Alias¹,

Othman²,

Li³

et al. 2015

JSM

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“…Our results suggest that increase in SOD and GSH levels in the colonic tissue of PCE-treated groups may be associated with saponins in the PC extract. Saponins were reported to carry antimicrobial, antiinflammatory, antitumoral, antiviral ve antioxidant properties (40), which are effective in GSH, GPx, CAT and SOD metabolism (41,42). Otherwise polyuronides have long-term and powerful antioxidant features (43) and polyuronides in the contents of PCE may be effective in the treatment of colitis.…”

Section: Discussionmentioning

confidence: 99%

Protective and Therapeutic Effects of Polygonum cognatum Meissn Aqueous Extract in Experimental Colitis

Çevik¹

2014

mpj

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“…SOD and GPx are two antioxidant enzymes which play a critical role in the cellular defense against the deleterious action of ROS and cellular products of free radical chain reactions. 22) While SOD catalyzes the conversion of superoxide free radical to less toxic hydrogen peroxide, GPx catalyzes the breakdown of hydrogen peroxide into water and oxygen and can also directly detoxify lipid peroxides generated by ROS. 23) As SOD and GPx are easily inactivated by ROS or lipid peroxides, this may explain a decrease in activities of these two enzymes observed in liver tissue of CCl 4 -intoxicated rats in our study.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effects of the Polysaccharide Isolated from <i>Tarphochlamys affinis</i> (Acanthaceae) against CCl<sub>4</sub>-Induced Hepatic Injury

Lin

Liu

Huang

et al. 2012

Biological & Pharmaceutical Bulletin

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This study was designed to investigate the protective effects of the polysaccharide isolated from Tarphochlamys affinis (PTA) against CCl 4 -induced hepatotoxicity in rats. Liver injury was induced in rats by the administration of CCl 4 twice a week for 2 weeks. During the experiment, the model group received CCl 4 only; the treatment groups received various drugs plus CCl 4 , whereas the normal control group received an equal volume of saline. Compared with the CCl 4 group, PTA significantly decreased the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in the serum and increased the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) in the liver. Moreover, the content of hepatic malondialdehyde (MDA) was reduced. Histological findings also confirmed the antihepatotoxic characterisation. In addition, PTA significantly inhibited the proinflammatory mediators, such as prostaglandin E 2 (PGE 2 ), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) and myeloperoxidase (MPO). Further investigation showed that the inhibitory effect of PTA on the pro-inflammatory cytokines was associated with the down-regulation of nuclear factor-kappa B (NF-κB). In brief, our results show that the protective effect of PTA against CCl 4 -induced hepatic injury may rely on its ability to reduce oxidative stress and suppress inflammatory responses. Key words Tarphochlamys affinis (Acanthaceae); polysaccharide; hepatoprotective effect; carbon tetrachlorideIn recent years, "oxidative stress" and its adverse effects on human health has become a subject of considerable interest of research. It is a well-documented fact that exposure of organisms to the exogenous and endogenous factors generates a wide range of reactive oxygen species (ROS), resulting in the homeostatic imbalance.1,2) Production of free radicals exceeded, such as superoxide, hydroxyl radicals, hydrogen peroxide and nitric oxide (commonly designated as ROS), was found certain to play multiple important roles in tissue damage and the loss of function.3) Development in the biomedicine points to the involvement of the free radicals in many diseases. The free radicals attack the unsaturated fatty acids in the biomembranes, yielding the membrane lipid peroxidation, the decrease in membrane fluidity, the loss of enzymes and the damage to membrane proteins and leading to the cell inactivation.4) The harmful action of the free radicals can, however, be blocked by the antioxidant substances, which scavenge the free radicals and detoxify the organism. Many studies have shown that natural polysaccharide, which were found largely in fruits and vegetables, have been confirmed to play an important part as free radical scavengers in the prevention of oxidative damage in living organism and can be exploited as novel potential antioxidants, and the effects have something to do with their chemical properties and architectural characteristics.5) T...

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Saponins from Panax japonicus Protect Against Alcohol-Induced Hepatic Injury in Mice by Up-regulating the Expression of GPX3, SOD1 and SOD3

Abstract: SPJ plays an important role in the protection of the structure and function of hepatic mitochondria and karyon by directly scavenging reactive oxygen species/free radicals and up-regulating the expression of antioxidant enzymes (SOD, GPX and CAT), especially to GPX3, SOD1 and SOD3.

Cited by 62 publications

References 24 publications

Supplementation of Psidium guajava (Guava) Fruit Polysaccharide Attenuates Paracetamol-induced Liver Injury by Enhancing the Endogenous Antioxidant Activity

Supplementation of Psidium guajava (Guava) Fruit Polysaccharide Attenuates Paracetamol-induced Liver Injury by Enhancing the Endogenous Antioxidant Activity

Protective and Therapeutic Effects of Polygonum cognatum Meissn Aqueous Extract in Experimental Colitis

Hepatoprotective Effects of the Polysaccharide Isolated from <i>Tarphochlamys affinis</i> (Acanthaceae) against CCl<sub>4</sub>-Induced Hepatic Injury

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