Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway

Huang, Hefei; Wang, Tianlun; Wang, Luopei; Huang, Yan; Li, Weili; Wang, Jin'e; Hu, Yuanlang; Zhou, Zhiyong

doi:10.1016/j.exger.2023.112305

Cited by 7 publications

(3 citation statements)

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“…Research has indicated that ginsenosides, ginseng polysaccharide, ginseng oligopeptide, and ginseng volatile oil exhibit significant anti-aging effects in aging mouse models ( Luo et al, 2020 ; Yang et al, 2021 ; Choi et al, 2022 ; Su et al, 2023 ; Sun et al, 2023 ). In particular, ginsenosides Rg1, Rg3, Rb1, Rb2, and Re in ginseng water extracts are known to possess notable anti-aging effects, largely due to their influence on the gut microbiota ( Huang et al, 2023 ; Shi et al, 2024 ). Therefore, ginseng is considered a non-negligible natural remedy for healthy aging and attracts extensive attention from scholars.…”

Section: Introductionmentioning

confidence: 99%

Research on the anti-aging mechanisms of Panax ginseng extract in mice: a gut microbiome and metabolomics approach

Lin,

Tang,

Liu

et al. 2024

Front. Pharmacol.

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Introduction: Aged-related brain damage and gut microbiome disruption are common. Research affirms that modulating the microbiota-gut-brain axis can help reduce age-related brain damage.Methods: Ginseng, esteemed in traditional Chinese medicine, is recognized for its anti-aging capabilities. However, previous Ginseng anti-aging studies have largely focused on diseased animal models. To this end, efforts were hereby made to explore the potential neuroprotective effects of fecal microbiota transplantation (FMT) from Ginseng-supplemented aged mice to those pre-treated with antibiotics.Results: As a result, FMT with specific modifications in natural aging mice improved animal weight gain, extended the telomere length, anti-oxidative stress in brain tissue, regulated the serum levels of cytokine, and balanced the proportion of Treg cells. Besides, FMT increased the abundance of beneficial bacteria of Lachnospiraceae, Dubosiella, Bacteroides, etc. and decreased the levels of potential pathogenic bacteria of Helicobacter and Lachnoclostridium in the fecal samples of natural aged mice. This revealed that FMT remarkably reshaped gut microbiome. Additionally, FMT-treated aged mice showed increased levels of metabolites of Ursolic acid, β-carotene, S-Adenosylmethionine, Spermidine, Guanosine, Celecoxib, Linoleic acid, etc., which were significantly positively correlated with critical beneficial bacteria above. Additionally, these identified critical microbiota and metabolites were mainly enriched in the pathways of Amino acid metabolism, Lipid metabolism, Nucleotide metabolism, etc. Furthermore, FMT downregulated p53/p21/Rb signaling and upregulated p16/p14, ATM/synapsin I/synaptophysin/PSD95, CREB/ERK/AKT signaling in brain damage following natural aging.Discussion: Overall, the study demonstrates that reprogramming of gut microbiota by FMT impedes brain damage in the natural aging process, possibly through the regulation of microbiota-gut-brain axis.

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Section: Introductionmentioning

confidence: 99%

Research on the anti-aging mechanisms of Panax ginseng extract in mice: a gut microbiome and metabolomics approach

Lin,

Tang,

Liu

et al. 2024

Front. Pharmacol.

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show abstract

“…Research has indicated that ginsenosides, ginseng polysaccharide, ginseng oligopeptide, and ginseng volatile oil exhibit significant anti-aging effects in aging mouse models (Luo et al, 2020;Yang et al, 2021;Choi et al, 2022;Su et al, 2023;Sun et al, 2023). In particular, ginsenosides Rg1, Rg3, Rb1, Rb2, and Re in ginseng water extracts are known to possess notable anti-aging effects, largely due to their influence on the gut microbiota (Huang et al, 2023;Shi et al, 2024). Therefore, ginseng is considered a nonnegligible natural remedy for healthy aging and attracts extensive attention from scholars.…”

Section: Introductionmentioning

confidence: 99%

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“…Research has indicated that ginsenosides, ginseng polysaccharide, ginseng oligopeptide, and ginseng volatile oil exhibit significant anti-aging effects in aging mouse models (Luo et al, 2020;Yang et al, 2021;Choi et al, 2022;Su et al, 2023;Sun et al, 2023). In particular, ginsenosides Rg1, Rg3, Rb1, Rb2, and Re in ginseng water extracts are known to possess notable anti-aging effects, largely due to their influence on the gut microbiota (Huang et al, 2023;Shi et al, 2024). Therefore, ginseng is considered a nonnegligible natural remedy for healthy aging and attracts extensive attention from scholars.…”

Section: Introductionmentioning

confidence: 99%

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Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway

Cited by 7 publications

References 58 publications

Research on the anti-aging mechanisms of Panax ginseng extract in mice: a gut microbiome and metabolomics approach

Research on the anti-aging mechanisms of Panax ginseng extract in mice: a gut microbiome and metabolomics approach

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