Saprochete capitata: Emerging Infections from Uncommon Microorganisms in Hematological Diseases

Duminuco, Andrea; Vetro, Calogero; Maugeri, Cinzia; Mauro, Elisa; Palumbo, Giuseppe A.; Parisi, Maria Giovanna; Esposito, Benedetta; Giuliano, G.; Romano, Alessandra; Raimondo, Francesco Di

doi:10.3390/hematolrep14020011

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…The 30-day mortality associated with invasive diseases was estimated to be 60%, primarily due to breakthrough infections in patients treated with echinocandins [ 5 ]. In our patient, his blood cultures grew positive yeast multiple times while being empirically treated with echinocandins since S. capitata is intrinsically resistant to echinocandins and highly resistant to fluconazole [ 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

Fungemia Due to Saprochaete capitata in a Non-Neutropenic Critically Ill Patient

Mawad,

Alfaifi,

Almazyed

et al. 2023

Cureus

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Saprochaete capitata is an uncommon yeast species; its impact on non-neutropenic patients appears to be on the rise. We describe a case of S. capitata fungemia in a critically ill end-stage kidney disease (ESKD) patient on peritoneal dialysis. The patient presented with mesenteric ischemia and underwent several laparotomies during hospitalization. His hospital stay was complicated as fungemia developed and spread to multiple sites, which resulted in severe complications and ultimately led to fatal outcomes. S. capitata 's diagnostic delay is a concern, but matrix-assisted laser desorption/Ionization time-of-flight (MALDI-TOF) mass spectrometry may help provide accurate identification. Our case highlights the need for prompt diagnosis and tailored antifungal therapy, especially when managing this challenging infection in immunocompromised patients.

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Section: Discussionmentioning

confidence: 99%

Fungemia Due to Saprochaete capitata in a Non-Neutropenic Critically Ill Patient

Mawad,

Alfaifi,

Almazyed

et al. 2023

Cureus

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“…M. capitatus and M. clavatus , earlier named as Geotrichum spp. or Saprochaeta spp., are considered emerging human pathogens causing severe invasive infections with mortality ranging from 40 to 80% [ 69 , 70 ]. Hospital-associated outbreaks have also been reported with the largest involving 39 cases in France in 2013 [ 71 ].…”

Section: Introductionmentioning

confidence: 99%

Candidiasis and Other Emerging Yeasts

Sharma

Chakrabarti²

2023

Curr Fungal Infect Rep

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Purpose of Review The review presents a comprehensive and updated information on the contemporary status of invasive candidiasis (IC), other emerging yeast infections, and the challenges they present in terms of at-risk population, specific virulence attributes, and antifungal susceptibility profile. Recent Findings With the advancement in medical field, there has been parallel expansion of vulnerable populations over the past two decades. This had led to the emergence of a variety of rare yeasts in healthcare settings, both Candida and non-Candida yeast causing sporadic cases and outbreaks. The advancements in diagnostic modalities have enabled accurate identification of rare Candida species and non-Candida yeast (NCY) of clinical importance. Their distribution and susceptibility profile vary across different geographical regions, thus necessitating surveillance of local epidemiology of these infections to improve patient outcomes. Summary The challenges in management of IC have been complicated with emergence of newer species and resistance traits. C. tropicalis has already overtaken C. albicans in many Asian ICUs, while C. auris is rising rapidly worldwide. Recent genomic research has reclassified several yeasts into newer genera, and an updated version of MALDI-TOF MS or ITS sequencing is necessary for accurate identification. Having a knowledge of the differences in predisposing factors, epidemiology and susceptibility profile of already established pathogenic yeasts, as well as new emerging yeasts, are imperative for better patient management.

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“…In contrast to Trichosporon whose distribution is worldwide, Saprochaeta has been found mostly in Europe. Saprochaeta Capitata is a ubiquitous yeast found in soil, water, and dairy products and is also recovered from the human respiratory and gastrointestinal tract 1 . Previously Saprochaeta Capitata was known as Geotrichum Capitatum, and Blastoschizomyces Capitatus.…”

Section: Introductionmentioning

confidence: 99%

Invasive fungal infection by saprochaeta capitata in an immunocompromised child- a case report from cancer hospital in Pakistan

Aslam,

Abbas,

Safdar

2023

J Pak Med Assoc

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Saprochaeta Capitata is an emerging fungus known to cause life-threatening infections in immunocompromised patients. Here, we describe the case of a 4-year-old male child seen in Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, after obtaining informed consent from the parents. He had Pre-B ALL (acute lymphoblastic leukaemia) and contracted this infection during induction chemotherapy. With the use of dual antifungals, he was able to survive this otherwise fatal fungal infection. Keywords: Saprochaeta capitata, invasive fungal infection, dual antifungal therapy, immunocompromised.

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Saprochete capitata: Emerging Infections from Uncommon Microorganisms in Hematological Diseases

Cited by 7 publications

References 20 publications

Fungemia Due to Saprochaete capitata in a Non-Neutropenic Critically Ill Patient

Fungemia Due to Saprochaete capitata in a Non-Neutropenic Critically Ill Patient

Candidiasis and Other Emerging Yeasts

Invasive fungal infection by saprochaeta capitata in an immunocompromised child- a case report from cancer hospital in Pakistan

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