SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors

Design of zigzag-like supramolecular 1D assemblies of polyfluorinated meta-arylenediamines and 18-crown-6

“…When the amount of crown ether is insufficient, associates of para-arylenediamines, possessing greater melting heats, crystallize selectively from solutions of the isomer mixtures, whereas metaisomers, possessing smaller melting heats, remain in a solution. The empirically revealed effect of molecular recognition was applied for the preparation of the highly purified polyfluoroarylenediamines [9,10], which are widely used as building blocks in the synthesis of polymers for optical communications [11][12][13], and as bioactive substance precursors [14]. In addition, the 1D supramolecular architecture suggests anisotropy of physical properties, which is the higher the less 1D structures interact with each other.…”

Selective mono-and diamination of polyfluorinated benzenes and pyridines with liquid ammonia

“…4 Polyfluorinated amines of the benzene and pyridine series are used in the synthesis of biologically active compounds. 5 It is known 6 that aminodehalogenation of arenes in aqueous ammonia, which is usually carried out in steel autoclaves at high temperatures (up to 250 °C), is often accompanied by competing transformations of arenes such as hydroxy and/or hydrodehalogenation involving water and the autoclave material. The version of the method of polyfluoroarene amination developed in this study im plies the use of liquid ammonia as both the reagent and the reaction medium.…”

Direct di- and triamination of polyfluoropyridines in anhydrous ammonia

“…Typical procedure for the reaction of polyhalopyridines with liquid NH 3 Polyhalopyridine was placed into a steel autoclave, the required amount of liquid NH 3 was added through a measuring funnel with back pressure and the autoclave was sealed. The reaction mixture was heated up to the given temperature upon stirring by rotation Entries 2,5,6,7,[9][10][11] Purity of the crude products in Entries 1, 3, 5, 7-11 is >95%, in Entries 2, 4, 6 is >90% ( 19 F NMR data).…”

“…The purpose of this study is the development of aminodefluorination of polychlorofluoropyridines in anhydrous ammonia as a selective method for preparation of novel halogenated pyridines containing two and (or) three amino groups, which are bioactive substance precursors [3,4] and building blocks in synthesis of condensation type polymers, in particular, hyperbranched polyimide membranes for gas separation applications [5] and anion-exchange nanofiltration membranes [6].…”